# Sesderma Azelac RU Liposomal Serum for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Sesderma](https://lovi.care/skincare/fr/brands/sesderma)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for dry skin due to the humectant action of glycerin, though it lacks sufficient emollient and occlusive ingredients for optimal hydration.
- The presence of 4-butylresorcinol and tranexamic acid provides moderate brightening benefits, which are supportive but not the primary focus for your dry or flaky skin concerns.
- The safety profile is good, with no risks of irritation for your dry skin due to the absence of harsh ingredients and the inclusion of soothing components like glycerin and tocopheryl acetate.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/oily-acne-prone-skin): High

## Key ingredients

Azelaic Acid, Tranexamic Acid, Retinol, Niacin, 4-Butylresorcinol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Co-encapsulation of alpha-tocopherol and alpha-tocopheryl acetate in nanostructured lipid carrier gel formulations significantly enhanced moisture retention up to 68% and improved skin elasticity in human volunteers compared to a solution gel. ([Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/))
- Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/))
- Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo. ([Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26341915/))
- 4-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2013](https://pubmed.ncbi.nlm.nih.gov/23205541/))
- Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications. ([Molecular Pharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28447799/))

## Why other serums fit dry skin better

- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

Based on limited data, users frequently report this serum effectively brightens the complexion and reduces hyperpigmentation like melasma, sun spots, and acne marks, leading to smoother and more luminous skin. Many appreciate its fast absorption and lightweight feel. Some users with sensitive or dry skin find it can be drying and recommend using a moisturizer.

- Liked: Fast absorption (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Acne control (sometimes noted)
- Disliked: Drying effect (sometimes noted)
- Disliked: High price (rarely noted)
- Disliked: Slow results (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Sesderma Azelac RU Serum work for dry skin?

This serum works moderately well for dry skin because it contains glycerin for basic moisture, though it lacks enough rich softening and sealing ingredients for the best hydration. It may help brighten your skin safely without causing irritation, but dry skin of this type needs formulas rich in ceramides, nourishing plant extracts, and barrier-supporting ingredients to stay truly smooth and comfortable.
Sources: [Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/)

### Which ingredients make this serum a good fit for dry skin?

Glycerin helps make this serum an acceptable fit for dry skin by pulling in moisture, while soothing ingredients like tocopheryl acetate keep irritation unlikely. However, a treatment for dry skin needs rich skin-softening oils and protective sealants to lock in hydration, alongside barrier-supporting components like ceramides.
Sources: [Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/)

### What does Tranexamic Acid do for dry skin?

Tranexamic acid helps repair and strengthen the outer barrier of dry skin, which keeps moisture locked in and improves hydration. This ingredient is unlikely to cause irritation and may help soothe redness while supporting overall skin recovery.
Sources: [International Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/23967870/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38712728/)

### Where does this serum go in a skincare routine for dry skin?

This treatment goes in the evening routine after cleansing, followed by a moisturizer. Putting treatments in the evening keeps things simple and adds extra safety around sun exposure.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C by applying vitamin C in the morning and this treatment at night, as this routine helps prevent irritation on dry skin. To properly care for dry skin, a product of this type needs rich softening and sealing ingredients that lock in moisture.

### How often should I use this serum?

This serum works for dry skin in the evening routine, starting at once a week and gradually increasing frequency as tolerated. It has a good safety profile with soothing ingredients like glycerin and tocopheryl acetate, but dry skin needs extra rich, softening, and sealing ingredients to stay fully hydrated.

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to cause breakouts or purging for dry skin, and it has a good safety profile with soothing components like glycerin and tocopheryl acetate. However, dry skin needs products that include rich moisturizing oils and butters to seal in hydration properly.
Sources: [Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol and alcohol denat).

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — €18.25 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €29.58 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/fr/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €7.50 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/propolis-synergy-toner/for/dry-skin) — Superior fit — €18.55 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/fr/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-skin) — Superior fit — €76.29 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Water, Lecithin, Propanediol, Alcohol, Bellis Perennis Flower Extract, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, Propylene Glycol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-Butylresorcinol, Alcohol Denat, Ascorbyl Glucoside, Azelaic Acid, Bha, Bht, Caprylic Capric Triglyceride, Carbomer, Citronellyl Methylcrotonate, Grapefruit Fruit Extract, Diacetyl Boldine, Dipotassium Phosphate, Disodium Edta, Disodium Phosphate, Ethylhexylglycerin, Glycerin, Glycyrrhetinic Acid, Hydrochloric Acid, Hydroxypropyl Cyclodextrin, Melissa Officinalis Leaf Extract, Morus Alba Root Extract, Niacin, Nicotiana Benthamiana Sh-Polypeptide-7, Parfum, Peg Ppg-20 6 Dimethicone, Phenethyl Alcohol, Phenoxyethanol, Polysorbate 20, Potassium Phosphate, Potassium Sorbate, Retinal, Retinol, Sodium Chloride, Sodium Cholate, Sodium Hydroxide, Tocopheryl Acetate, Tranexamic Acid, Triethanolamine, Triisopropanolamine, Undecylenoyl Phenylalanine, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin (this page)
- Italy: https://lovi.care/skincare/it/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin