# Prequel Barrier Therapy Skin Protectant Cream for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/fr/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Prequel](https://lovi.care/skincare/fr/brands/prequel)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few products fit it even better.

## Why this fit

- This product offers excellent barrier repair for your normal skin due to ceramides and cholesterol, which enhance resilience and support collagen production alongside adenosine for fine lines.
- Oat and allantoin provide anti-inflammatory action and barrier repair, though additional humectants could further optimize hydration for your skin.
- The formula is safe for your skin, with no risks of irritation from harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/prequel/barrier-therapy-skin-protectant-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/fr/p/prequel/barrier-therapy-skin-protectant-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/prequel/barrier-therapy-skin-protectant-cream/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/fr/p/prequel/barrier-therapy-skin-protectant-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/prequel/barrier-therapy-skin-protectant-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/prequel/barrier-therapy-skin-protectant-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Oat, Multi-Ceramides, Allantoin, Adenosine

## What the research says

- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- A repair cream containing Rhealba oat plantlets extract, l-ALA-l-GLU dipeptide, and hyaluronic acid provided immediate relief and was judged by doctors as good or very good in 96.8% of cases for wound healing in 2,363 patients following dermatological acts. ([Clinical, Cosmetic and Investigational Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/30519069/))
- Topically applied Avena sativa and Avena Rhealba oatmeal extracts significantly reduced skin irritation parameters including a* parameter increase and blood flow increase compared to vehicle in 12 healthy individuals subjected to the sodium lauryl sulfate irritation model. ([Skin Pharmacology and Applied Skin Physiology, 2002](https://pubmed.ncbi.nlm.nih.gov/11867969/))
- Colloidal oat extracts diminished pro-inflammatory cytokines in vitro and colloidal oat lotion improved skin dryness, scaling, roughness, and itch intensity in healthy female subjects compared to baseline. ([Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25607907/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Prophylactic application of a topical scar gel containing Allium cepae extract, allantoin, and heparin significantly improves patient-assessed scar color, stiffness, and irregularity compared to no treatment in women following a cesarean section. ([Journal of Drugs in Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24509969/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures. ([The Journal of Investigative Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17301835/))

## What reviewers say

While the vast majority find it deeply hydrating and an excellent value for the size, a subset of users reported burning sensations or breakouts, and the product faced a significant recall in 2024 due to contamination concerns.

- Liked: Great value (often mentioned)
- Liked: Non-greasy texture (often mentioned)
- Liked: Versatile use (sometimes noted)
- Disliked: Availability issues (sometimes noted)
- Disliked: Burning sensation (sometimes noted)
- Disliked: Recall history (sometimes noted)
- Disliked: Caused breakouts (rarely noted)

## Questions and answers

### What makes Prequel Barrier Therapy Skin Protectant Cream a great fit for mature skin?

This cream is a great fit because multi-ceramides and cholesterol help repair the skin barrier and support firmness, while adenosine works to soften fine lines. Oat and allantoin also calm the skin and keep it comfortable without any irritation.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/)

### Which ingredients make this cream a good fit for mature skin?

Multi-ceramides, cholesterol, oat, allantoin, and adenosine make this cream a great fit for mature skin by repairing the skin barrier, keeping it calm, and helping smooth out fine lines. Adenosine and ceramides support collagen production and resilience, while oat and allantoin soothe the skin with a very safe and gentle profile.
Sources: [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### What does Oat do for mature skin?

Oat helps calm dry and irritated skin while supporting the skin barrier to keep it smooth and comfortable. It may also protect against daily environmental stress that contributes to aging.
Sources: [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25607907/), [Journal of Drugs in Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27272074/)

### What do Ceramides do for mature skin?

Ceramides help keep mature skin hydrated and smooth by repairing the outer moisture barrier and supporting water retention. This type of ingredient helps improve skin texture and elasticity while reducing dryness, which makes it particularly useful for aging skin that tends to lose moisture easily.
Sources: [Dermatologic Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/31585489/), [International Journal of Immunopathology and Pharmacology, 2008](https://pubmed.ncbi.nlm.nih.gov/18336739/)

### Where does this cream go in a skincare routine for mature skin?

This cream goes in the moisturizer step of your morning and evening routine. Using a moisturizer regularly helps improve dryness, visual smoothness, and overall skin comfort.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this cream with retinol, and in what order?

Yes, you can use this cream alongside retinol, applying the cream after your retinol treatment to help your skin tolerate it better and stay calm and comfortable. The multi-ceramides, cholesterol, and soothing ingredients in this formula support your skin barrier while you use stronger active treatments.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/)

### How often should I use this cream?

You can use this cream daily as part of your morning and evening routine to help keep your skin feeling soft and well-moisturized. A consistent daily routine with a good moisturizer is unlikely to cause irritation and significantly improves overall dryness and comfort over time.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, as it has a very low risk of causing breakouts based on reviewer feedback and contains soothing ingredients. It features a safe formula with no harsh ingredients that could irritate your skin.

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — €20.46 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/fr/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €95.00 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/fr/p/cosrx/advanced-snail-96-mucin-power-essence/for/mature-skin) — Superior fit — €14.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/fr/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €76.29 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Oat, Water, Carthamus Tinctorius Seed Oil, Cetyl Alcohol, Glycerin, Butyrospermum Parkii Butter, Caprylic Capric Triglyceride, Dimethicone, C10-18 Triglycerides, Allantoin, Adenosine, Cetearyl Olivate, Sorbitan Olivate, Ceramide Ap, Ceramide Eos, Ceramide Eop, Ceramide Np, Ceramide Ns, Cholesterol, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Glycolipids, Sodium Stearoyl Glutamate, Behenic Acid, Ceteareth-25, Glycine Soja Sterols, Hydrogenated Palm Glycerides, Hydrogenated Palm Glycerides Kernel, Carbomer, Phenoxyethanol, Ethylhexylglycerin, Tocopheryl Acetate, Tetrasodium Glutamate Diacetate, Sodium Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin