# Perricone MD Rejuvenating Moisturizer for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Perricone MD](https://lovi.care/skincare/fr/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for your normal skin, as glycerin and macadamia ternifolia seed oil provide excellent moisturization and barrier support, while tetrahexyldecyl ascorbate and palmitoyl glycine address wrinkles and fine lines by supporting collagen production.
- The inclusion of ribose and lactic acid offers mild exfoliation and skin renewal, complementing the primary anti-aging benefits.
- The product is safe for your skin, with rosemary leaf extract providing soothing properties and no harsh or prohibited ingredients present.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, Tetrahexyldecyl Ascorbate, Ribose, Lactic Acid, Macadamia Ternifolia Seed Oil

## What the research says

- Palmitoyl glycine and cocoyl alanine demonstrated complementary anti-aging properties and superior anti-wrinkle efficacy compared to a market reference ingredient in Caucasian women. ([International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/19732187/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))

## What reviewers say

This moisturizer is praised for its rich texture that plumps, firms, and smooths aging or dry skin without greasiness. Many users report reduced fine lines and improved radiance. Some users experienced product pilling or sensitivity to the fragrance.

- Liked: Deeply hydrating (often mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Non-greasy formula (sometimes noted)
- Liked: Reduces lines (sometimes noted)
- Disliked: Product pilling (sometimes noted)
- Disliked: Fragrance sensitivity (rarely noted)
- Disliked: White cast (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Perricone MD Rejuvenating Moisturizer work for mature skin?

Perricone MD Rejuvenating Moisturizer works reasonably well for mature skin, as it uses glycerin and macadamia nut oil to keep skin soft and supported, while vitamin C and peptides help smooth out fine lines. It also provides gentle renewal with lactic acid and ribose, though other options may offer even better results for your skin type. To truly thrive, a product for mature skin needs a rich blend of deeply nourishing hydrators, powerful smoothing ingredients, and soothing components that keep the skin barrier strong and irritation-free.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for mature skin?

Tetrahexyldecyl ascorbate and palmitoyl glycine make this cream a good fit for mature skin because they help smooth wrinkles and fine lines by supporting collagen, while glycerin and macadamia seed oil keep skin soft with deep moisture. To fit mature skin even better, a product like this needs exceptionally safe anti-aging ingredients, potent nourishment for fine lines, and rich moisturizing components that prevent irritation.
Sources: [International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/19732187/)

### What does Acyl-Glutathione do for mature skin?

Acyl-Glutathione helps mature skin by smoothing fine wrinkles and keeping the skin hydrated while providing strong antioxidant protection. Topical application of glutathione-based products is safe and may improve skin quality and brightness.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/), [Giornale Italiano Di Dermatologia E Venereologia, 2019](https://pubmed.ncbi.nlm.nih.gov/28399620/)

### What does Vitamin C do for mature skin?

Vitamin C helps smooth out wrinkles, fade dark spots, and calm redness on mature skin. It also boosts collagen production to make skin firmer and protects against everyday environmental stress.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/29104718/), [Dermatologic Surgery, 2002](https://pubmed.ncbi.nlm.nih.gov/11896774/)

### Where does it go in a skincare routine for mature skin?

This moisturizing treatment goes in the morning routine after a hydrating toner and before SPF, or in the evening routine as your moisturizer step. It helps keep skin soft and supports your skin barrier, though a product for mature skin also needs strong anti-aging ingredients like retinol or peptides for better results.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying your retinol first and following with this moisturizer to help keep your skin comfortable. Using a moisturizing cream with retinol helps reduce dryness and supports your skin barrier while you treat fine lines.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use it?

You can use this moisturizing treatment twice daily to help keep your mature skin soft, smooth, and well-hydrated. Regular application may also support collagen production and improve the look of fine lines over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, as it has a safe formula with no harsh ingredients. However, to truly thrive, mature skin needs rich nourishing oils and deep barrier support to stay soft and smooth.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use it around the eyes or on my body?

You can use this moisturizer on your body, but it is not specifically tailored for the very thin skin around the eyes. To properly care for mature skin, a product of this type needs rich nourishing oils, targeted collagen-supporting ingredients, and gentle renewing agents to keep the skin feeling soft and smooth.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — €20.46 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/fr/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €95.00 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/fr/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/mature-skin) — Superior fit — €17.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/fr/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — €24.00 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/rejuvenating-moisturizer/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/rejuvenating-moisturizer/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/rejuvenating-moisturizer/for/mature-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/rejuvenating-moisturizer/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/rejuvenating-moisturizer/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/rejuvenating-moisturizer/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/rejuvenating-moisturizer/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/rejuvenating-moisturizer/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/rejuvenating-moisturizer/for/mature-skin