# Perricone MD High Potency Hyaluronic Intensive Hydrating Serum for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Perricone MD](https://lovi.care/skincare/fr/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your oily skin, this serum leverages niacinamide for oil control and hydration without greasiness, complemented by acetyl glucosamine to support skin barrier function and address breakouts.
- The high concentrations of sodium hyaluronate and its crosspolymer provide excellent moisturizing benefits, ensuring superior hydration for your skin.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Sodium Hyaluronate, Niacinamide, Squalane, Ceramide Np, Acetyl Glucosamine

## What the research says

- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))

## What reviewers say

Users consistently praise this serum for its ability to deliver immediate and deep hydration, often noting that it visibly plumps fine lines and leaves skin feeling exceptionally soft and smooth. While the vast majority find the texture elegant and fast-absorbing, a small minority of users find it slightly sticky or heavy compared to more watery serums.

- Liked: Deep hydration (mostly mentioned)
- Liked: Fast absorbing (often mentioned)
- Liked: Plumps fine lines (often mentioned)
- Liked: Smooths texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Disliked: Heavy texture (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Scent (rarely noted)
- Disliked: Sticky feel (rarely noted)

## How to apply

- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Perricone MD High Potency Hyaluronic Intensive Hydrating Serum a great fit for oily acne-prone skin?

This serum is a great fit because it uses niacinamide to control oil and hydrate without feeling greasy, while acetyl glucosamine helps support the skin barrier and address breakouts. It also provides deep moisture with sodium hyaluronate and keeps skin calm and safe from irritation thanks to soothing components like glycerin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

This serum is a great fit for your oily acne-prone skin because it uses niacinamide to help control oil without feeling greasy and acetyl glucosamine to support your skin barrier and handle breakouts. It also includes sodium hyaluronate to give your skin plenty of moisture without clogging pores.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for oily acne-prone skin?

Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35796638/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### Where does it go in a skincare routine for oily acne-prone skin?

This serum goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening keeps things simple and avoids extra safety concerns around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to keep your skin hydrated and calm, and following it with your retinol. Using a barrier-supporting moisturizer helps reduce the dryness and irritation that often come with retinol use.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/), [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use it?

Use this serum in the evening as part of your routine. Daily application helps keep your skin hydrated and balanced without feeling greasy.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14571069/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is a great fit for oily acne-prone skin because it uses niacinamide to help control oil without feeling greasy, alongside sodium hyaluronate for lightweight moisture. It is unlikely to cause irritation or breakouts, as it is free of harsh ingredients and includes soothing components.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/)

### Can I use it around the eyes or on my body?

You can use this moisturizing treatment around the eyes, as the skin in that area is thin and benefits from gentle hydration. It is safe for the body too, though applying it there may use up the product quickly.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/fr/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/oily-acne-prone-skin) — Superior fit — €29.00 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/fr/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/oily-acne-prone-skin) — Superior fit — €22.00 at Amazon
- [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/fr/p/isntree/green-tea-fresh-serum/for/oily-acne-prone-skin) — High fit — €12.56 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/fr/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — €11.35 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/fr/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/fr/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-acne-prone-skin) — Superior fit — €34.30 at Amazon

## Where to buy

- Amazon.fr: €40.80 (https://www.amazon.fr/dp/B0C9VSKYLX?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €71.25 (https://www.lookfantastic.fr/p/perricone-md-hp-hyaluronic-intensive-hydrating-serum-2oz-fg/13156918/)
- Notino: €76.50 (https://www.notino.fr/perricone-md/high-potency-classics-serum-hydratant-intense-a-lacide-hyaluronique/p-16146252/)
Prices checked 10 Oct – 4 Nov 2026.

## Ingredients

Water, Dimethicone, Butylene Glycol, Niacinamide, Acetyl Glucosamine, Squalane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysilicone-11, Cetearyl Olivate, Hdi Trimethylol Hexyllactone Crosspolymer, Polyisobutene, Sorbitan Olivate, Dimethyl Isosorbide, Polysorbate 20, 1,2-Hexanediol, Caprylyl Glycol, Dimethyl Mea, Hydroxyacetophenone, Citric Acid, Ceramide Np, Caprylyl Capryl Glucoside, Sorbitan Oleate, Sodium Gluconate, Spermidine, Silica, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium Hyaluronate Crosspolymer, Ethylhexylglycerin, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Glycerin, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-acne-prone-skin
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- France: https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-acne-prone-skin (this page)
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