# Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Perricone MD](https://lovi.care/skincare/fr/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few moisturizers fit it even better.

## Why this fit

- Excellent suitability for your dry skin is provided by glycerin, linum usitatissimum seed oil, and macadamia ternifolia seed oil, which offer deep moisturization and nourishment through humectant and emollient actions.
- The presence of S-palmitoylglutathione and ribose further enhances skin elasticity and provides general skincare benefits, supporting your dry or flaky skin.
- The product is safe for your dry and sensitive skin, as it contains no harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, Tetrahexyldecyl Ascorbate, Lactic Acid, Macadamia Ternifolia Seed Oil, Vitamin F Blend

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- Topical application of linoleic acid achieved an almost 25% reduction in the overall size of follicular casts and microcomedones over a 1-month treatment period in patients with mild acne compared to no change at placebo-treated sites. ([Clinical and Experimental Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9692305/))
- Topical conjugated linolenic acid significantly reduced edema on post-procedure Day 3 and itching on Days 1 and 3, and improved wrinkling at Day 14 compared to 1% dimethicone ointment in 34 subjects undergoing fractionated CO2 laser resurfacing of the face. ([The Journal of Clinical and Aesthetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/29344315/))
- Liposomal formulation of linoleic acid significantly enhances its skin whitening effect compared to non-liposomal forms in UV-stimulated guinea pig and human skin. ([Biological & Pharmaceutical Bulletin, 2004](https://pubmed.ncbi.nlm.nih.gov/15056874/))

## What reviewers say

This moisturizer is highly praised for its rich, velvety texture that absorbs quickly to provide intense hydration, making it a favorite for dry and mature skin types. Users frequently report a visible improvement in skin softness, radiance, and a firmer, more supple appearance, though some note that it may not fully erase deep-set wrinkles.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Fast absorbing (often mentioned)
- Liked: Pleasant texture (often mentioned)
- Disliked: Expensive price (often mentioned)
- Liked: Improves radiance (sometimes noted)
- Disliked: Limited wrinkle results (sometimes noted)
- Disliked: Strong fragrance (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Perricone MD Rejuvenating Moisturizer a great fit for dry sensitive skin?

This moisturizer is a great fit because glycerin and plant seed oils provide deep moisture and nourishment, while soothing ingredients help improve skin feel without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for dry sensitive skin?

Glycerin, linseed oil, and macadamia oil make this cream a great fit by deeply quenching and nourishing dry skin. S-palmitoylglutathione and ribose further improve skin smoothness and support flaky areas safely without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Acyl-Glutathione do for dry sensitive skin?

Acyl-Glutathione helps protect dry sensitive skin against environmental and oxidative stress while improving overall moisture and smoothness. It is unlikely to cause irritation and supports a calm, healthy look.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/), [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### What does Vitamin C do for dry sensitive skin?

Vitamin C helps make dry, sensitive skin feel softer and calmer while improving firmness and reducing redness. Studies show that gentle forms of vitamin C can improve skin hydration and elasticity safely without causing irritation.
Sources: [Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38397772/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/)

### Where does this cream go in a skincare routine for dry sensitive skin?

This moisturizing treatment goes in the evening routine after your toner and before your moisturizer. It is a great fit for dry sensitive skin because it provides deep moisturization and nourishment while containing no harsh ingredients that could cause irritation.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying the retinol first, letting it absorb, and then following with this moisturizer to help keep your dry skin calm and hydrated. This approach is unlikely to cause irritation because the product contains no harsh ingredients and features nourishing oils that support your skin barrier.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment in your evening routine, applying it once a day to support your dry and sensitive skin. Daily application helps improve skin hydration, smoothness, and overall barrier comfort over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for dry sensitive skin?

This cream is unlikely to clog pores or cause breakouts for dry sensitive skin because it is free of harsh or prohibited ingredients that typically trigger irritation. It helps keep skin soft and comfortable without causing congestion.

### Can I use this cream around the eyes or on my body?

You can safely use this moisturizing treatment around the eyes and on the body because it contains gentle ingredients that suit sensitive skin. It is unlikely to cause irritation and helps improve skin texture and moisture in delicate areas.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry sensitive skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-sensitive-skin) — Superior fit — €20.46 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/fr/p/the-ordinary/natural-moisturizing-factors-ha/for/dry-sensitive-skin) — Superior fit — €13.11 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/fr/p/l-occitane/immortelle-divine-cream/for/dry-sensitive-skin) — Superior fit — €95.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/fr/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €7.50 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/fr/p/skin1004/centella-asiatica-toning-toner/for/dry-sensitive-skin) — Superior fit — €18.79 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/fr/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — €29.95 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-sensitive-skin (this page)
- Italy: https://lovi.care/skincare/it/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-sensitive-skin
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