# Perricone MD Deep Crease Serum for dry skin

**Lovi Fit: High fit for dry skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Perricone MD](https://lovi.care/skincare/fr/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your dry skin due to the presence of Squalane and Glycerin, which provide emollient and humectant actions to smooth intercellular lipids and draw water into the skin. The product also offers excellent wrinkle reduction for minimizing fine lines and wrinkles due to the presence of Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8.
- While S-Palmitoylglutathione and Tetrahexyldecyl Ascorbate offer antioxidant and brightening effects, their concentrations are not optimized for your primary concern of dry or flaky skin.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/dry-skin): High (this page)
- [Combination skin](https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))

## What reviewers say

Users in their 40s and 50s frequently praise this serum for its lightweight, non-greasy feel and its ability to hydrate and soften the appearance of expression lines. While results are gradual, consistent use leads to firmer, smoother-looking skin.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Hydrating formula (often mentioned)
- Liked: Softens deep lines (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Improves firmness (sometimes noted)
- Disliked: Dropper issues (sometimes noted)
- Disliked: Gradual results (sometimes noted)
- Disliked: Fragrance sensitivity (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Perricone MD Deep Crease Serum a great fit for dry skin?

Perricone MD Deep Crease Serum is a great fit for dry skin because it contains squalane and glycerin to smooth and draw moisture into the skin, alongside peptides that help minimize fine lines and wrinkles. It is very safe and unlikely to cause irritation.
Sources: [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Which ingredients make this serum a good fit for dry skin?

Squalane and glycerin make this serum a great fit for dry skin by smoothing skin cells and drawing in moisture. It is unlikely to cause irritation and helps soften dry patches.

### What does Acyl-Glutathione do for dry skin?

Acyl-glutathione helps protect dry skin by boosting antioxidant defenses and supporting moisture levels. It is unlikely to irritate dry skin and may help keep it feeling soft and smooth.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/)

### What does Palmitoyl Glutathione do for dry skin?

Palmitoyl glutathione helps dry skin by boosting moisture and improving smoothness. It also supports the skin's antioxidant system to help keep the surface soft and healthy.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/), [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in the evening routine after cleansing and before your moisturizer. Putting it in the evening helps keep your routine simple and avoids extra sensitivity around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol product. This helps smooth dry skin and minimize fine lines while keeping irritation unlikely due to the formula's gentle safety profile.

### How often should I use this serum?

This treatment is a great fit for your dry skin and is meant to be used in the evening as part of your routine. It is unlikely to cause irritation because it lacks harsh ingredients, helping your skin stay smooth and soft.

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores, cause breakouts, or lead to purging for dry skin because it has a very safe formula with no harsh or prohibited ingredients that could upset your skin. It helps keep your skin smooth and calm while minimizing fine lines.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool).

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — €18.25 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €29.58 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/fr/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €7.50 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/propolis-synergy-toner/for/dry-skin) — Superior fit — €18.55 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/fr/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-skin) — Superior fit — €76.29 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic Capric Triglyceride, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/deep-crease-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/deep-crease-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/deep-crease-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/deep-crease-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/dry-skin (this page)
- Italy: https://lovi.care/skincare/it/p/perricone-md/deep-crease-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/deep-crease-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/deep-crease-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/deep-crease-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/deep-crease-serum/for/dry-skin