# Paula's Choice Niacinamide 20% Treatment for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Paula's Choice](https://lovi.care/skincare/fr/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your normal skin and goals of reducing redness and irritation is provided by the high concentration of niacinamide and acetyl glucosamine, which work to refine skin texture and reduce the appearance of blemishes.
- The inclusion of licorice root extract and panthenol further soothes inflammation and provides hydration, complementing the primary ingredients for enhanced comfort.
- The product is safe for your sensitive skin, featuring a gentle formulation free from harsh irritants and enriched with soothing agents.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin): Superior
- [Sensitive skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Acetyl Glucosamine, Ascorbyl Glucoside, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Portulaca Oleracea Extract Purslane Extract

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Facial masks containing low-temperature extracted Portulaca oleracea protect sensitive skin from photothermal stimulation and improve skin barrier function during photorejuvenation. ([Cutaneous and Ocular Toxicology, 2025](https://pubmed.ncbi.nlm.nih.gov/41182319/))
- Portulaca oleracea extract ameliorated skin barrier damage and inflammation induced by combined exposure to glycolic acid and UVB in HaCaT cells. ([Cutaneous and Ocular Toxicology, 2022](https://pubmed.ncbi.nlm.nih.gov/35920724/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical purslane at 5% and 10% concentrations achieved alleviation of symptoms and lesion remission comparable to topical 0.1% triamcinolone acetonide in 34 subjects with oral lichen planus over 90 days. ([BMC Oral Health, 2023](https://pubmed.ncbi.nlm.nih.gov/37726676/))
- Topical application of a crude extract of Portulaca oleracea accelerates wound healing by decreasing wound surface area and increasing tensile strength in Mus musculus JVI-1, with the greatest contraction achieved at a single dose of 50mg compared to other dosages. ([Journal of Ethnopharmacology, 2003](https://pubmed.ncbi.nlm.nih.gov/12963132/))
- A polysaccharide fraction (VPOP3) from Portulaca oleracea L. reduced reactive oxygen species and lipid peroxidation, inhibited UVB-induced apoptosis, and downregulated melanogenic signaling pathway proteins in cells and zebrafish. ([Phytomedicine, 2023](https://pubmed.ncbi.nlm.nih.gov/37229889/))

## What reviewers say

Based on a very large amount of data, users with oily, combination, and aging skin frequently report significant improvements in skin texture and a visible reduction in the appearance of enlarged pores and "orange-peel" skin. Many praise its ability to smooth and brighten the complexion. A notable minority with sensitive skin experienced irritation, redness, or burning due to the high concentration of niacinamide.

- Liked: Minimizes enlarged pores (often mentioned)
- Liked: Smoother skin texture (often mentioned)
- Liked: Brightens skin tone (sometimes noted)
- Liked: Lightweight non-sticky texture (sometimes noted)
- Disliked: Causes skin irritation (sometimes noted)
- Disliked: Expensive price point (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: No visible results (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice Niacinamide 20% Treatment a great fit for sensitive skin?

Paula's Choice Niacinamide 20% Treatment is a great fit for sensitive skin because it features a gentle formulation packed with high concentrations of niacinamide and acetyl glucosamine to calm redness and refine texture. Licorice root extract and panthenol further soothe irritation while adding moisture to keep your skin feeling comfortable.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this treatment a good fit for sensitive skin?

This treatment is a great fit for sensitive skin because it features high concentrations of niacinamide and acetyl glucosamine to calm redness, alongside soothing licorice root extract, purslane extract, and panthenol to hydrate and comfort easily irritated skin.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Cutaneous and Ocular Toxicology, 2025](https://pubmed.ncbi.nlm.nih.gov/41182319/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Acetyl Glucosamine do for sensitive skin?

Acetyl glucosamine helps keep skin hydrated and smooth while fading dark spots. It is generally gentle and unlikely to irritate dry or sensitive skin types.
Sources: [Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/), [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19845667/)

### Where does this treatment go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Putting treatments in the evening helps provide extra safety around sun exposure.

### Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol by applying the treatment first and following with your retinol, or by using them on alternating nights to keep your skin calm. Because niacinamide helps soothe irritation while smoothing texture, this combination is unlikely to trigger extra redness or discomfort.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Cutaneous and Ocular Toxicology, 2025](https://pubmed.ncbi.nlm.nih.gov/41182319/)

### How often should I use this treatment?

This treatment is a great fit for sensitive skin and can be used in your evening routine. It is generally safe to start slowly and see how your skin feels before applying it more frequently.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Cutaneous and Ocular Toxicology, 2025](https://pubmed.ncbi.nlm.nih.gov/41182319/)

### Can this treatment clog pores, cause breakouts or purging for sensitive skin?

This treatment is unlikely to cause breakouts on sensitive skin, as its gentle formulation relies on soothing and hydrating ingredients that help calm irritation. Reviewers rarely report breakouts, and the product is designed without harsh irritants to keep skin smooth and comfortable.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €139.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/fr/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €37.67 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €28.02 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/fr/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €27.60 at Amazon
- Moisturizer with Sun Protection: [innisfree Daily Mild Sunscreen](https://lovi.care/skincare/fr/p/innisfree/daily-mild-sunscreen/for/sensitive-skin) — Superior fit — €24.00 at Amazon

## Where to buy

- Amazon.fr: €53.55 (https://www.amazon.fr/dp/B08SW6VPJL?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Niacinamide, Pentylene Glycol, Butylene Glycol, Glycerin, Acetyl Glucosamine, Ascorbyl Glucoside, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Spiraea Ulmaria Extract, Portulaca Oleracea Extract Purslane Extract, Camellia Japonica Flower Extract, Epigallocatechin Gallate, Boerhavia Diffusa Root Extract, Camellia Sinensis Leaf Extract, Allantoin, Lecithin, Pullulan, Panthenol, Silica, Xanthan Gum, Sclerotium Gum, Propanediol, Sodium Phytate, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin (this page)
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin