# Paula's Choice Niacinamide 20% Treatment for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Paula's Choice](https://lovi.care/skincare/fr/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your oily skin as niacinamide and acetyl glucosamine effectively refine texture and reduce blemishes by targeting inflammation and oil production.
- The inclusion of epigallocatechin gallate and ascorbyl glucoside further supports seboregulation and skin evening, complementing your goals for acne and oiliness.
- The product is safe for your skin, with no risk of irritation due to the absence of harsh ingredients and the presence of soothing components like licorice root extract and allantoin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin): Superior
- [Sensitive skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Niacinamide, Acetyl Glucosamine, Ascorbyl Glucoside, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Portulaca Oleracea Extract Purslane Extract

## What the research says

- Epigallocatechin-3-gallate significantly improved acne in patients compared to the control side during an 8-week clinical trial. ([The Journal of Investigative Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23096708/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of Glycyrrhiza glabra and Sophora japonica flavonoid-rich fractions individually and in combination significantly increased the wound healing rate and reduced oxidative stress compared to wound and Nolaver-treated groups. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37049756/))
- Topical purslane at 5% and 10% concentrations achieved alleviation of symptoms and lesion remission comparable to topical 0.1% triamcinolone acetonide in 34 subjects with oral lichen planus over 90 days. ([BMC Oral Health, 2023](https://pubmed.ncbi.nlm.nih.gov/37726676/))
- Facial masks containing low-temperature extracted Portulaca oleracea protect sensitive skin from photothermal stimulation and improve skin barrier function during photorejuvenation. ([Cutaneous and Ocular Toxicology, 2025](https://pubmed.ncbi.nlm.nih.gov/41182319/))
- Portulaca oleracea extract ameliorated skin barrier damage and inflammation induced by combined exposure to glycolic acid and UVB in HaCaT cells. ([Cutaneous and Ocular Toxicology, 2022](https://pubmed.ncbi.nlm.nih.gov/35920724/))

## What reviewers say

Based on a very large amount of data, users with oily, combination, and aging skin frequently report significant improvements in skin texture and a visible reduction in the appearance of enlarged pores and "orange-peel" skin. Many praise its ability to smooth and brighten the complexion. A notable minority with sensitive skin experienced irritation, redness, or burning due to the high concentration of niacinamide.

- Liked: Minimizes enlarged pores (often mentioned)
- Liked: Smoother skin texture (often mentioned)
- Liked: Brightens skin tone (sometimes noted)
- Liked: Lightweight non-sticky texture (sometimes noted)
- Disliked: Causes skin irritation (sometimes noted)
- Disliked: Expensive price point (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: No visible results (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice Niacinamide 20% Treatment a great fit for oily acne-prone skin?

Paula's Choice Niacinamide 20% Treatment is a great fit because niacinamide and acetyl glucosamine smooth your skin and help control oil and blemishes. It also features soothing ingredients like licorice root extract and allantoin to calm your face without causing irritation, along with epigallocatechin gallate to further help balance oily skin.
Sources: [The Journal of Investigative Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23096708/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

This serum is a great fit for your oily acne-prone skin because niacinamide and acetyl glucosamine help smooth texture and reduce blemishes by targeting oil production and inflammation. Epigallocatechin gallate and ascorbyl glucoside also support oil control, while soothing ingredients like licorice root extract and allantoin keep your skin calm with a low risk of irritation.
Sources: [The Journal of Investigative Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23096708/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### What does Acetyl Glucosamine do for oily acne-prone skin?

Acetyl glucosamine helps fade dark spots and uneven areas while keeping your skin hydrated and smooth. Studies show it is safe for daily use and works especially well when paired with ingredients like niacinamide.
Sources: [Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/), [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19845667/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in your evening routine, as treatments are placed then for simplicity and extra safety around sun exposure. It is safe for oily acne-prone skin, with no risk of irritation due to the absence of harsh ingredients and the presence of soothing components.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying this serum first and following it with your retinol product. This approach helps manage oil and blemishes while keeping your skin calm and comfortable.

### How often should I use this serum?

This treatment works best when used in your evening routine. It is unlikely to cause irritation and helps calm your skin while balancing oil.
Sources: [The Journal of Investigative Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23096708/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

Paula's Choice Niacinamide 20% Treatment is unlikely to cause breakouts for oily acne-prone skin since it helps control oil and calm inflammation. Reviewers rarely report breakouts, and the gentle formula includes soothing ingredients that keep irritation low.
Sources: [The Journal of Investigative Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23096708/), [Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — €18.25 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/fr/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — €37.67 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/fr/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — €37.67 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/fr/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — €11.35 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/fr/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/fr/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — €17.47 at Amazon

## Where to buy

- Amazon.fr: €53.55 (https://www.amazon.fr/dp/B08SW6VPJL?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Niacinamide, Pentylene Glycol, Butylene Glycol, Glycerin, Acetyl Glucosamine, Ascorbyl Glucoside, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Spiraea Ulmaria Extract, Portulaca Oleracea Extract Purslane Extract, Camellia Japonica Flower Extract, Epigallocatechin Gallate, Boerhavia Diffusa Root Extract, Camellia Sinensis Leaf Extract, Allantoin, Lecithin, Pullulan, Panthenol, Silica, Xanthan Gum, Sclerotium Gum, Propanediol, Sodium Phytate, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin (this page)
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin