# numbuzin 5 Glutathione Vitamin Concentrated Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [numbuzin](https://lovi.care/skincare/fr/brands/numbuzin)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as niacinamide and tranexamic acid provide antioxidant activity and melanogenesis regulation to address brightening and evening of skin tone. Glycerin and panthenol offer hydration and soothing benefits supportive for oily shine, but the formula lacks targeted ingredients for significant oil control.
- The product is safe for your combination skin due to the absence of harsh ingredients and the inclusion of soothing agents like Alpha Bisabolol and Allantoin, ensuring a gentle experience.
- While effective for general skincare benefits, the serum's primary focus is not on intensive oil control for your oily shine concerns.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/oily-acne-prone-skin): High

## Key ingredients

Glutathione, Niacinamide, 3-O-Ethyl Ascorbic Acid, Tranexamic Acid, Alpha-Arbutin

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, users with dullness, hyperpigmentation, and sensitive skin frequently praise this serum for its ability to fade acne scars and even out skin tone without causing irritation. The majority report a "glass skin" glow and rapid absorption, while a small minority experienced breakouts or found the brightening effects too slow to appear.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Gentle on skin (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Hydrating glow (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Slow results (rarely noted)
- Disliked: Tacky finish (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does numbuzin 5 Glutathione Vitamin Concentrated Serum work for combination skin?

This serum works moderately well for combination skin because ingredients like niacinamide, tranexamic acid, glycerin, and panthenol help brighten skin tone, hydrate, and soothe oily areas. However, it lacks targeted oil control ingredients, so combination skin needs a product of this type that also contains ingredients like propolis or zinc PCA to regulate oiliness.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this serum a good fit for combination skin?

Niacinamide and tranexamic acid help brighten and even out your skin tone, while glycerin and panthenol provide hydration and soothing benefits for oily areas. However, a treatment for combination skin also needs targeted oil-control ingredients like propolis or zinc PCA to manage shine effectively.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Glutathione do for combination skin?

Glutathione helps brighten sun-exposed areas and reduce dark spots for combination skin, while also improving moisture and smoothness. It is unlikely to cause irritation and maintains a safe profile for regular use.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [International Journal of Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39444151/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine for combination skin. To properly care for combination skin, this type of product also needs targeted ingredients for significant oil control.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol, but because this product focuses on brightening rather than oil control, combination skin needs a formula with targeted oil-absorbing ingredients to better manage oily shine.

### How often should I use this serum?

You can use this serum in the evening. Combination skin needs products that balance hydration with targeted oil control and lightweight soothing ingredients.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause breakouts for combination skin because it avoids harsh ingredients and includes soothing agents, though a few reviewers have occasionally reported breakouts. Combination skin works best with targeted oil-control ingredients and lightweight hydration to balance oily and dry zones without clogging pores.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Behenyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — €18.25 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/fr/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €35.99 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/fr/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €389.34 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice RESIST Perfectly Balanced Foaming Cleanser](https://lovi.care/skincare/fr/p/paula-s-choice/perfectly-balanced-foaming-cleanser/for/combination-skin) — Superior fit — €32.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/fr/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/fr/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €17.47 at Amazon

## Where to buy

- Amazon.fr: €23.00 (https://www.amazon.fr/dp/B0FZT6DPCD?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Notino: €15.90 (https://www.notino.fr/numbuzin/no-5-goodbye-blemish-serum-serum-revitalisant-intense-anti-imperfections-de-la-peau/p-16312715/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Vaccinium Vitis-Idaea Fruit Extract, Butylene Glycol, Niacinamide, Panthenol, Tranexamic Acid, Water, 1,2-Hexanediol, Neopentyl Glycol Dicaprate, Caprylic Capric Triglyceride, Sorbitol, Bifida Ferment Filtrate, Chondrus Crispus Extract, Butyrospermum Parkii Butter, Saccharum Officinarum Extract, Alpha-Arbutin, Sodium Hyaluronate, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Melia Azadirachta Leaf Extract, Curcuma Longa Root Extract, Corallina Officinalis Extract, Tremella Fuciformis Extract, Pentylene Glycol, Glycerin, 3-O-Ethyl Ascorbic Acid, Alpha Bisabolol, Tromethamine, Ethylhexylglycerin, Adenosine, Hydrogenated Lecithin, Allantoin, Glutathione, Ceramide Np, Beta-Glucan, Dipotassium Glycyrrhizate, Tocopherol, L Ascorbic Acid, Ascorbyl Glucoside, Tocopheryl Acetate, Hydroxypropyl Cyclodextrin, Ubiquinone, Alpha Lipoic Acid, Potassium Hydroxide, Behenyl Alcohol, Carbomer, Xanthan Gum, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin (this page)
- Italy: https://lovi.care/skincare/it/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin