# Neutrogena Retinol Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/fr/p/neutrogena/retinol-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Neutrogena](https://lovi.care/skincare/fr/brands/neutrogena)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for normal skin, as Retinol and Hyaluronic Acid work to stimulate collagen and hydrate, which can help with fine lines and wrinkles.
- Ascorbic Acid provides antioxidant protection, supporting general skin health, though it is not specifically targeted for wrinkle reduction.
- The product is safe for your normal skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing Hyaluronic Acid.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/neutrogena/retinol-serum/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/fr/p/neutrogena/retinol-serum/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/fr/p/neutrogena/retinol-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/neutrogena/retinol-serum/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/fr/p/neutrogena/retinol-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/neutrogena/retinol-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/neutrogena/retinol-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/neutrogena/retinol-serum/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/neutrogena/retinol-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Hyaluronic Acid, Ascorbic Acid

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels. ([The Journal of Investigative Dermatology, 1995](https://pubmed.ncbi.nlm.nih.gov/7561157/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))

## What reviewers say

Based on a very large amount of data, this retinol serum is highly regarded for its lightweight, fast-absorbing texture and its effectiveness in improving skin radiance, texture, and the appearance of fine lines within a few weeks. Many users with various skin types report positive anti-aging outcomes. Some individuals experience mild irritation or dryness, and a minority noted a lack of significant results for deeper wrinkles.

- Liked: Improves texture (mostly mentioned)
- Liked: Lightweight, non-greasy (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Liked: Radiant, glowing skin (sometimes noted)
- Disliked: Limited wrinkle results (sometimes noted)
- Disliked: Mild irritation (sometimes noted)
- Disliked: Fragrance presence (rarely noted)
- Disliked: Potential breakouts (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Neutrogena Retinol Serum work for mature skin?

Neutrogena Retinol Serum works moderately well for mature skin, as retinol and hyaluronic acid help smooth fine lines and hydrate. Mature skin needs products that are exceptionally safe and effective at reducing wrinkles while containing high-quality antioxidants, hydrating components, and skin-repairing ingredients for optimal results.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Which ingredients make this serum a good fit for mature skin?

Retinol and hyaluronic acid make this serum a good fit for mature skin by helping to smooth fine lines and keep the skin hydrated. This product works for mature skin, though a treatment for this skin type needs to be exceptionally safe without irritation risks, highly effective against wrinkles, and rich in peptides and humectants.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### What does Retinol do for mature skin?

Retinol helps smooth out fine lines and wrinkles while improving overall skin thickness and firmness over time. It may also cause temporary dryness, scaling, or stinging as your skin gets used to it.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in your evening routine, as treatments with actives are typically used at night for simplicity and extra safety around sun exposure. It is safe for your skin with no risks of irritation.

### Can I use this serum with niacinamide, and in what order?

You can use this serum with niacinamide by applying niacinamide first and following with this treatment once it absorbs, or by using niacinamide in the morning and this treatment at night. Combining them is generally safe, as niacinamide helps keep mature skin calm while retinol works on fine lines.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. A product of this type works best for mature skin when it includes ingredients like retinol and hyaluronic acid to help smooth fine lines and keep skin hydrated.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts, as it has a low risk for potential breakouts on mature skin. However, since it contains retinol, it may cause mild irritation or skin purging when you first start using it.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €139.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/fr/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — €599.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/fr/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €76.29 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Water, Dimethicone, Glycerin, Retinol, Hyaluronic Acid, Ascorbic Acid, Caprylyl Glycol, Cetearyl Olivate, Sorbitan Olivate, Polysorbate 20, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neutrogena/retinol-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neutrogena/retinol-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/neutrogena/retinol-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/neutrogena/retinol-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/neutrogena/retinol-serum/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/neutrogena/retinol-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/neutrogena/retinol-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/neutrogena/retinol-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/neutrogena/retinol-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/neutrogena/retinol-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/neutrogena/retinol-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neutrogena/retinol-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neutrogena/retinol-serum/for/mature-skin