# Neutrogena Invisible Daily Defense Face Serum SPF 60 for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/fr/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Neutrogena](https://lovi.care/skincare/fr/brands/neutrogena)
Category: [Sunscreens and SPF moisturizers](https://lovi.care/skincare/fr/best/sunscreens)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few sunscreens fit it even better.

## Why this fit

- Highly suitable for your combination skin, this product offers excellent UV protection with its blend of avobenzone, homosalate, octisalate, and octocrylene, while glycerin and zingiber officinale root extract provide hydration and anti-inflammatory benefits.
- Silica and aluminum starch octenylsuccinate work to absorb excess oil, offering moderate benefits for your oily shine.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/fr/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/fr/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/fr/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/oily-acne-prone-skin): High

## Key ingredients

Avobenzone, Homosalate, Octisalate, Octocrylene, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Chemical sunscreens containing avobenzone, octocrylene, homosalate, and octisalate showed no to minimal risks of dermal irritation, sensitization, photo-allergy, and photo-irritation in human subjects. ([Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40911743/))
- The application of a sunscreen formulation containing ethylhexyl methoxycinnamate, ethylhexyl salicylate, methyl anthranilate, and octocrylene does not significantly affect critical acne-related species such as Cutibacterium acnes and Staphylococcus epidermidis, refuting the induction of facial dysbiosis in men. ([Archives of Dermatological Research, 2024](https://pubmed.ncbi.nlm.nih.gov/39499337/))
- Encapsulation of ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane in lipid microparticles significantly reduced their in vivo human skin penetration compared to nonencapsulated filters. ([Skin Pharmacology and Physiology, 2011](https://pubmed.ncbi.nlm.nih.gov/21336009/))
- Microencapsulation of the BMDBM/HP-beta-CD complex in lipid microparticles significantly decreased the percutaneous penetration of the UV filter into the stratum corneum of human volunteers compared to the non-encapsulated sunscreen agent. ([Journal of Pharmaceutical and Biomedical Analysis, 2011](https://pubmed.ncbi.nlm.nih.gov/20934293/))
- Following human skin application of an O/W emulsion containing 2% BMDBM loaded in lipospheres, 15% of the sunscreen accumulated in the uppermost layers of the stratum corneum without remarkably modifying skin permeation compared to unencapsulated sunscreen. ([Skin Pharmacology and Physiology, 2008](https://pubmed.ncbi.nlm.nih.gov/17934329/))
- Dermal application of a sunscreen containing 10% homosalate in four volunteers resulted in delayed elimination with terminal half-times around 24 h and a bioavailability of cis-homosalate a factor of 2 lower than trans-homosalate, while metabolite ratios supported using oral-route urinary excretion fractions for dermal exposure assessments. ([Archives of Toxicology, 2024](https://pubmed.ncbi.nlm.nih.gov/38485782/))
- Homosalate exhibited the highest permeation among tested filters with a relative permeability rate of 4.2% and a depth of 60 um, and specific thickeners and emulsifiers successfully reduced its permeation without inhibiting the skin permeation of niacinamide. ([Photodermatology, Photoimmunology & Photomedicine, 2026](https://pubmed.ncbi.nlm.nih.gov/42594379/))
- An online-SPE-LC-MS/MS method successfully quantified specific urinary homosalate metabolites for up to 96 hours after dermal sunscreen application in a volunteer and detected metabolites exclusively in three German pilot participants who had used sunscreen within five days. ([Analytica Chimica Acta, 2021](https://pubmed.ncbi.nlm.nih.gov/34399889/))
- Simulated real-life dermal sunscreen exposure in twenty human volunteers leads to the systemic bioavailability and urinary excretion of the UV filter 2-ethylhexyl salicylate and its metabolite, reaching concentration peaks at 7 to 8 hours with 70-80% of overall excretion within 24 hours. ([Archives of Toxicology, 2019](https://pubmed.ncbi.nlm.nih.gov/31435713/))
- Controlled single dermal exposure to an EHS-containing sunscreen in three volunteers resulted in delayed systemic resorption with elimination half-lives between 6.6 and 9.7 hours, where the parent compound EHS occurred as the dominant urinary parameter. ([Archives of Toxicology, 2024](https://pubmed.ncbi.nlm.nih.gov/39134695/))
- Dermal exposure to EHS-containing sunscreen leads to the urinary excretion of EHS as the main biomarker alongside major metabolites 5OH-EHS, 5cx-EPS, 4OH-EHS, and 5oxo-EHS, measured using an extended enzymatic hydrolysis and on-line SPE LC-MS/MS method. ([Talanta, 2024](https://pubmed.ncbi.nlm.nih.gov/38728806/))
- Incorporating rosmarinic acid into sunscreens enhanced the in vivo SPF of octocrylene by over 157% and reduced lipid peroxidation in the human stratum corneum. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40227214/))
- Early application of sunscreen after ablative fractional skin resurfacing significantly increased the sensitization rate of the UV-filter, octocrylene, and the sunscreen compared to intact skin. ([The Journal of Dermatological Treatment, 2015](https://pubmed.ncbi.nlm.nih.gov/25633273/))
- Dermal sunscreen exposure in 20 healthy volunteers led to plasma concentrations of avobenzone, octocrylene, and its metabolite CDAA reaching up to 11 μg/L, 25 μg/L, and 1352 μg/L, respectively. ([Environment International, 2019](https://pubmed.ncbi.nlm.nih.gov/31470219/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

This serum is highly praised for its invisible, non-greasy finish that works well for all skin tones and sits smoothly under makeup. However, while it provides effective hydration and sun protection, some users experience eye irritation or find the texture slightly oily, particularly in humid conditions or on naturally oily skin. This summary is based on a very large amount of data and should definitely be taken into account.

- Liked: No white cast (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Smooth under makeup (often mentioned)
- Liked: Hydrating formula (sometimes noted)
- Disliked: Eye stinging (sometimes noted)
- Disliked: Greasy feel (sometimes noted)
- Disliked: Pore clogging (rarely noted)

## How to apply

- Apply this sunscreen during your AM routine every single day. Make sure to reapply ⏱ every two hours if you stay outside.
- Apply this sunscreen as the very last step of your morning routine after your moisturizer. Allow your moisturizer to ⏳ sink in for a minute first.
- Smooth an even layer over your face and gently pat it into the skin without harsh rubbing. Be sure to cover all exposed areas thoroughly.
- For the best finish on your combination skin, apply the sunscreen on completely dry skin over your moisturizer. This helps control any oily shine throughout the day.
- Avoid getting the product directly into your eyes. Do a small patch test before your first full application.
- Video: https://storage.pora.ai/53e9a436d82fca2a189dd08aa21de2fd.mp4

## Questions and answers

### What makes Neutrogena Invisible Daily Defense Serum a great fit for combination skin?

This sunscreen is a great fit for combination skin because it combines UV filters with glycerin and ginger extract to hydrate dry areas and calm irritation, while silica and starch powders help absorb excess oil in shiny zones. It is also very safe and unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for combination skin?

Avobenzone, homosalate, octisalate, and octocrylene make this serum a great fit by offering strong sun protection, while glycerin and ginger root extract add soothing moisture. Silica and starch help soak up extra oil in shiny spots without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Avobenzone do for combination skin?

Avobenzone helps protect combination skin from sun damage, but it is best used in a stable formulation because it can break down under sunlight. Encapsulating this ingredient or combining it with photostability boosters may reduce skin irritation and improve safety.
Sources: [European Journal of Pharmaceutical Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/36455708/), [Journal of Photochemistry and Photobiology. B, Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/26318281/)

### What does Homosalate do for combination skin?

Homosalate helps protect combination skin from UV rays while generally being well tolerated without causing skin irritation. Chemical sunscreens containing this ingredient show a very low likelihood of causing redness or allergic reactions.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40911743/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes last in your morning routine after your moisturizer, providing high sun protection while keeping your skin calm and hydrated. It is very unlikely to cause irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40911743/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum in the morning after your moisturizer as the final step before sunscreen, since this product functions as an SPF. It is safe for combination skin and is unlikely to cause irritation.

### How often should I use this serum?

Use this sunscreen every morning as the final step of your daytime routine. Its chemical filters and gentle ingredients are very unlikely to cause irritation on your combination skin.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40911743/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores for your combination skin since it has a very low risk of pore clogging and does not cause breakouts or purging. Silica and aluminum starch octenylsuccinate help absorb excess oil, while the formula avoids harsh ingredients that could upset your skin.
Sources: [Archives of Dermatological Research, 2024](https://pubmed.ncbi.nlm.nih.gov/39499337/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for combination skin

- [IS Clinical Eclipse SPF 50+](https://lovi.care/skincare/fr/p/is-clinical/eclipse-spf-50/for/combination-skin) — Superior fit — €123.38 at Amazon
- [innisfree Daily Mild Sunscreen](https://lovi.care/skincare/fr/p/innisfree/daily-mild-sunscreen/for/combination-skin) — Superior fit — €24.00 at Amazon
- [Missha All Around Safe Block Soft Finish Sun Milk SPF 50+](https://lovi.care/skincare/fr/p/missha/all-around-safe-block-soft-finish-sun-milk/for/combination-skin) — High fit — €24.00 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice RESIST Perfectly Balanced Foaming Cleanser](https://lovi.care/skincare/fr/p/paula-s-choice/perfectly-balanced-foaming-cleanser/for/combination-skin) — Superior fit — €32.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/fr/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/fr/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €17.47 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Avobenzone, Homosalate, Octisalate, Octocrylene, Water, Butyloctyl Salicylate, Glycerin, Alcohol Denat, Silica, Dimethicone, Aluminum Octenylsuccinate Starch, Polyurethane-62, Phenoxyethanol, Pentylene Glycol, Sodium Acryloyldimethyltaurate Vp Crosspolymer, Acrylates Dimethicone Copolymer, Glyceryl Stearate, Chlorphenesin, Styrene Acrylates Copolymer, Zingiber Officinale Root Extract, Menthyl Lactate, Tocopheryl Acetate, Disodium Edta, Trideceth-6, Chrysanthemum Parthenium Flower Leaf Stem Juice, Sodium Hydroxide, Yellow 5, Ci 16035
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin
- France: https://lovi.care/skincare/fr/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin (this page)
- Italy: https://lovi.care/skincare/it/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neutrogena/invisible-daily-defense-face-serum-spf-60/for/combination-skin