# Neutrogena Hydro Boost+ Niacinamide Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/fr/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Neutrogena](https://lovi.care/skincare/fr/brands/neutrogena)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Highly suitable for your normal skin, this serum effectively addresses wrinkles and fine lines with niacinamide and acetyl glucosamine, which work to improve skin texture and elasticity while niacinamide also aids in seboregulation.
- Glycerin and sodium hyaluronate provide excellent moisturizing benefits, ensuring your skin remains hydrated and smooth.
- The product is safe for your skin, containing no harsh ingredients and posing no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/neutrogena/hydro-boost-niacinamide-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/fr/p/neutrogena/hydro-boost-niacinamide-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/fr/p/neutrogena/hydro-boost-niacinamide-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/neutrogena/hydro-boost-niacinamide-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/neutrogena/hydro-boost-niacinamide-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/neutrogena/hydro-boost-niacinamide-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/neutrogena/hydro-boost-niacinamide-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/neutrogena/hydro-boost-niacinamide-serum/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Sodium Hyaluronate, Glycerin, Acetyl Glucosamine, Dimethicone

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Liposomes containing N-acetyl glucosamine prepared using the fusion method significantly increased skin moisture content compared to empty liposomes in human volunteers over a 5-hour period. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23725302/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate. ([Skin Research and Technology, 2000](https://pubmed.ncbi.nlm.nih.gov/11428946/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))

## What reviewers say

This fragrance-free serum is widely praised for its lightweight, fast-absorbing texture that delivers immediate hydration without greasiness, making it suitable for both oily and dry skin types. Users frequently report improvements in skin texture and brightness, though results regarding dark spots and pore size can vary, with a small minority experiencing breakouts. Based on a very large amount of data, this should be definitely taken into account.

- Liked: Lightweight & fast (mostly mentioned)
- Liked: Effective hydration (often mentioned)
- Liked: Gentle & fragrance-free (often mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Evens skin tone (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Sticky residue (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Neutrogena Hydro Boost+ Niacinamide Serum a great fit for mature skin?

Neutrogena Hydro Boost+ Niacinamide Serum is a great fit for mature skin because it contains niacinamide and acetyl glucosamine to smooth fine lines and improve texture, alongside glycerin and sodium hyaluronate to keep skin hydrated and soft. This formula is safe and unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

Niacinamide and acetyl glucosamine make this serum a great fit because they help smooth fine lines and improve skin texture and elasticity. Glycerin and sodium hyaluronate further support mature skin by providing deep hydration to keep your face feeling soft and smooth.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing, for simplicity and extra safety around sun exposure. It is unlikely to irritate mature skin while helping smooth wrinkles and fine lines.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to keep your skin hydrated and smooth while helping to reduce wrinkles and fine lines. Preconditioning and continuing skin application with a moisturizing treatment helps your skin tolerate retinol better and is unlikely to cause irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

This serum is used in the evening step of your routine. Daily application helps keep your skin hydrated and smooth while improving the look of fine lines and wrinkles.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it contains no harsh ingredients and poses very little risk of irritation. A small number of reviewers do mention occasional breakouts, but the formula is generally safe and well-tolerated.

### Can I use this serum around the eyes or on my body?

Yes, you can use this serum around the eyes and on your body because its gentle formula poses no risk of irritation. It helps smooth fine lines and keeps the skin hydrated in these areas.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/fr/p/revision-skincare/hydrating-serum/for/mature-skin) — High fit — €191.05 at Amazon
- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/fr/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/mature-skin) — High fit — €29.00 at Amazon
- [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/fr/p/isntree/green-tea-fresh-serum/for/mature-skin) — High fit — €12.56 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/fr/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — €24.00 at Amazon

## Where to buy

- Amazon.fr: €15.89 (https://www.amazon.fr/dp/B0DYVL6M3S?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Notino: €13.50 (https://www.notino.fr/neutrogena/hydro-boost-serum-hydratant-a-la-niacinamide/p-16298757/)
Prices checked 17 Oct – 5 Nov 2026.

## Ingredients

Water, Niacinamide, Glycerin, Acetyl Glucosamine, Pentylene Glycol, Dimethicone, Phenoxyethanol, Carbomer, Disodium Edta, Sodium Hyaluronate, Sodium Hydroxide, Ethylhexylglycerin, Dimethicone Vinyl Dimethicone Crosspolymer, Amodimethicone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neutrogena/hydro-boost-niacinamide-serum/for/mature-skin