# NEOGEN DERMALOGY Probiotics Youth Repair Cream for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/fr/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [NEOGEN DERMALOGY](https://lovi.care/skincare/fr/brands/neogen-dermalogy)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent suitability for your normal skin is provided by sodium hyaluronate and ceramides, which offer humectant and barrier repair actions, respectively, addressing your concerns about wrinkles and fine lines.
- The formula's peptides, such as acetyl hexapeptide-8 and adenosine, work synergistically to promote collagen synthesis and skin elasticity, further enhancing your skin's youthful appearance.
- This product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like niacinamide and allantoin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/neogen-dermalogy/probiotics-youth-repair-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/neogen-dermalogy/probiotics-youth-repair-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/fr/p/neogen-dermalogy/probiotics-youth-repair-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/neogen-dermalogy/probiotics-youth-repair-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/neogen-dermalogy/probiotics-youth-repair-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/neogen-dermalogy/probiotics-youth-repair-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/neogen-dermalogy/probiotics-youth-repair-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/neogen-dermalogy/probiotics-youth-repair-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Probiotics, Sodium Hyaluronate, Ceramide Np, Copper Tripeptide-1, Royal Jelly Extract

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Applying an essence containing royal jelly extract significantly increased the stratum corneum water content of the cheeks compared to placebo in healthy Japanese adults over 4 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35778882/))
- A prototype body cream containing bee venom, propolis, honey, beeswax, and royal jelly demonstrated stability for 90 days, high antioxidant capacity of 85.45%, lack of cytotoxicity with over 70% cell viability, and no irritation or allergic reaction in dermatological analysis, while improving skin parameters in a panel test. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35238152/))
- Royal jelly protects against epidermal stress caused by UVB and menadione through the upregulation of NQO1 expression by its active compound 10-hydroxy-2-decenoic acid. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34884772/))

## What reviewers say

Based on limited data, users consistently praise this cream for its ability to deeply hydrate and plump the skin without feeling overly heavy, making it suitable for dry, combination, and sensitive skin types. Many reviewers reported a visible improvement in skin texture, noting that their face felt "bouncy," smoother, and firmer after consistent use, though opinions on the finish (sticky vs. non-sticky) vary.

- Liked: Deep hydration (mostly mentioned)
- Liked: Texture and absorption (often mentioned)
- Liked: Pleasant scent (sometimes noted)
- Liked: Skin improvements (sometimes noted)
- Disliked: Tacky finish (sometimes noted)
- Liked: Gentle formula (rarely noted)
- Disliked: Not for very dry skin (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Price concerns (rarely noted)
- Disliked: Scent disliked (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes NEOGEN Probiotics Youth Repair Cream one of the best fits for mature skin?

This cream is an exceptional fit for mature skin because sodium hyaluronate and ceramides lock in moisture and repair the skin barrier to smooth out wrinkles and fine lines. Peptides and adenosine help promote collagen synthesis and improve skin elasticity for a more youthful appearance. Additionally, soothing components like niacinamide and allantoin make it safe and unlikely to cause irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this cream a good fit for mature skin?

This cream is a great fit for mature skin because sodium hyaluronate and ceramides help smooth out fine lines while keeping the skin hydrated and strong. Additionally, peptides and adenosine work together to improve skin elasticity and support a more youthful appearance.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What do Probiotics do for mature skin?

Probiotics help mature skin by improving moisture, firmness, and elasticity while smoothing out wrinkles. Topical application of these ingredients supports the skin microbiome and may reduce signs of aging.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38174442/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36718014/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment goes in the morning routine after your hydrating toner, and in the evening routine as your final moisturizing step.

### Can I use this cream with retinol, and in what order?

Yes, you can use this cream with retinol, and applying it first helps build skin tolerance while improving the overall treatment response. The formula's ceramides and soothing ingredients help reduce potential dryness and irritation when combined with active treatments.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily as part of your morning and evening routine. Regular application helps improve skin hydration, elasticity, and the appearance of fine lines and wrinkles while supporting the skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin. Its formula avoids heavy oils and includes soothing components, making it safe and well-suited for your daily routine.

### Can I use this cream around the eyes or on my body?

You can safely use this moisturizing treatment on your body, but you should check with the manufacturer before applying it around your eyes because the thin skin there requires specialized testing. The formula has a safe and gentle profile with soothing ingredients like niacinamide and allantoin, making it unlikely to cause irritation.

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol and stearyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for mature skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — €20.46 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/fr/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €95.00 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/fr/p/cosrx/advanced-snail-96-mucin-power-essence/for/mature-skin) — Superior fit — €14.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/fr/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — €24.00 at Amazon

## Where to buy

- Notino: €19.50 (https://www.notino.fr/neogen-dermalogy/probiotics-youth-repair-cream-creme-legere-raffermissante-anti-premiers-signes-du-viellissement/p-16076783/)
Prices checked 14 Oct 2026.

## Ingredients

Water, Butylene Glycol, Caprylic Capric Triglyceride, Glycerin, Trehalose, Cyclopentasiloxane, Glyceryl Stearate, 1,2-Hexanediol, Niacinamide, Octyldodecyl Myristate, Peg-100 Stearate, Cyclohexasiloxane, Hydrogenated C6-14 Olefin Polymers, Dimethicone, Phytosteryl Behenyl Octyldodecyl Lauroyl Glutamate, Butyrospermum Parkii Butter Shea Butter, Palmitic Acid, Hydrogenated Olive Lauryl Esters Oil, Helianthus Annuus Seed Oil Sunflower Seed Oil, Stearic Acid, Cetyl Peg Ppg-10 1 Dimethicone, Polyacrylamide, Cetyl Alcohol, Stearyl Alcohol, Tocopheryl Acetate, C13-14 Isoparaffin, Dimethiconol, Beeswax, Ethylhexylglycerin, Laureth-7, Microcrystalline Wax, Adenosine, Sodium Hyaluronate, Coptis Japonica Extract, Lactobacillus Lysate Ferment, Isopentyldiol, Dextrin, Theobroma Cacao Extract, Tocopherol, Betaine, Allantoin, Xylitol, Panthenol, Hydrolyzed Collagen, Juglans Regia Seed Oil, Squalane, Lactic Acid, Undaria Pinnatifida Extract, Polydecene, Propanediol, Honey Extract, Sodium Pca, Sodium Lactate, Arginine, Olea Europaea Oil Fruit Olive Oil Fruit, Bifida Lysate Ferment, Aspartic Acid, Adansonia Digitata Seed Oil, Hibiscus Sabdariffa Flower Extract, Pca, Ceramide Np, Hydrogenated Lecithin, Acacia Senegal Gum, Agar, Gluconic Acid, Streptococcus Thermophilus Ferment, Xanthan Gum, Glycine, Alanine, Royal Jelly Extract, Musa Sapientum Fruit Extract, Tuber Melanosporum Extract, Propolis Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Artemisia Capillaris Extract, Serine, Valine, Guaiazulene, Caprylyl Glycol, Cholesterol, Isoleucine, Threonine, Proline, Tuber Magnatum Extract, Phenylalanine, Histidine, Phellinus Linteus Extract, Glutathione, Ceramide Ns, Ceramide, Ceramide Eop, Ceramide Ap, Glucose, Beta-Glucan, Chondrus Crispus Extract, Panax Ginseng Extract Berry, Phytosterols, Hydroxypropyltrimonium Hyaluronate, Crocus Sativus Flower Extract, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Copper Tripeptide-1, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Acetyl Hexapeptide-8, Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Pentapeptide-4, Hexapeptide-9, Tripeptide-2, Nonapeptide-1, Hexapeptide-11, Potassium Hyaluronate, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neogen-dermalogy/probiotics-youth-repair-cream/for/mature-skin