# NATURIUM Multi-Peptide Advanced Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [NATURIUM](https://lovi.care/skincare/fr/brands/naturium)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- This serum offers moderate benefits for normal skin, with squalane and glycerin supporting hydration and barrier function, but lacks specialized ingredients to address your redness and irritation.
- The inclusion of peptides like Acetyl Hexapeptide-8 and Copper Palmitoyl Heptapeptide-14 provides anti-aging effects, which are secondary to your primary concerns.
- The product is safe for your sensitive skin, as it contains soothing sunflower and rosemary leaf extracts and avoids harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Multi-Peptide Blend, Ferulic Acid, Hydrolyzed Collagen, Squalane, Acetyl Hexapeptide-8

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- A topical serum with a peptide blend showed superior or comparable skin recovery to a moisturizer following fractional CO2 laser and radiofrequency microneedling in Asian subjects. ([Dermatology and Therapy, 2026](https://pubmed.ncbi.nlm.nih.gov/42322532/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))
- Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo. ([The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/40464749/))
- Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))

## Why other serums fit sensitive skin better

- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))

## What reviewers say

Users with dry, mature, and sensitive skin frequently praise this serum for its ability to visibly plump fine lines and deliver a "glass-skin" radiance without irritation. Many report smoother texture and improved hydration, while a minority of users experienced breakouts or frustration with the packaging design.

- Liked: Elegant texture (often mentioned)
- Liked: Hydrating and plumping (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Great value (sometimes noted)
- Liked: Visible anti-aging (sometimes noted)
- Disliked: Poor pump design (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Runs out quickly (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Naturium Multi-Peptide Advanced Serum work for sensitive skin?

Naturium Multi-Peptide Advanced Serum works as an average fit for sensitive skin, offering basic hydration and a safe formula while lacking targeted ingredients for redness and irritation. To fit this skin better, a product of this type needs specialized soothing ingredients like niacinamide or snail secretion filtrate to calm redness while keeping the skin soft and smooth.

### Which ingredients make this serum a good fit for sensitive skin?

Squalane and glycerin help support hydration and barrier function, while sunflower and rosemary leaf extracts provide soothing benefits for sensitive skin. To truly excel for this skin, a treatment of this type needs dedicated ingredients that actively calm redness and irritation.

### What do Peptides do for sensitive skin?

Peptides help calm and support sensitive skin by reducing irritation and strengthening the skin barrier over time. These ingredients are generally well-tolerated and may help improve overall comfort without causing unexpected flare-ups.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39761149/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682399/)

### What does Ferulic Acid do for sensitive skin?

Ferulic acid helps calm sensitive skin by defending against everyday environmental damage like sun and pollution, while supporting the skin barrier to keep it strong. It is unlikely to irritate when formulated well, and products for sensitive skin benefit from soothing antioxidants and gentle barrier-repairing ingredients.
Sources: [Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/), [Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/)

### Where does it go in a skincare routine for sensitive skin?

This treatment goes in your evening routine after your toner and before your moisturizer. A product of this type needs soothing ingredients and extra moisture to help calm redness and irritation for this skin.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and letting it absorb before putting on your retinol. This product works for your sensitive skin, but a product of this type needs calming plant extracts, soothing agents, and hydration boosters to properly target redness and irritation.

### How often should I use it?

You can use this treatment in the evening as part of your routine. This product of this type needs soothing ingredients like centella asiatica, niacinamide, or green tea extract, along with barrier-supporting ceramides, to calm redness and irritation on sensitive skin.

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to cause breakouts or clogged pores for sensitive skin, as only a small number of reviewers report breakouts. To best care for sensitive skin, this type of product needs soothing ingredients and a gentle formula that calms redness while keeping the skin barrier hydrated and calm.

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €139.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/fr/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €37.67 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €28.02 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/fr/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €27.60 at Amazon
- Moisturizer with Sun Protection: [innisfree Daily Mild Sunscreen](https://lovi.care/skincare/fr/p/innisfree/daily-mild-sunscreen/for/sensitive-skin) — Superior fit — €24.00 at Amazon

## Where to buy

- Amazon.fr: €36.72 (https://www.amazon.fr/dp/B0DJFWCRF2?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Propanediol, Caprylic Capric Triglyceride, Isopentyldiol, Ethylhexyl Polyhydroxystearate, Squalane, Tetradecane, Glyceryl Stearate Citrate, Butyrospermum Parkii Butter Shea Butter, Polyglyceryl-3 Stearate, Helianthus Annuus Extract Sunflower Extract, Rice Bran Extract, Mannitol, Phosphatidylcholine, Ferulic Acid, Arginine, Acetyl Hexapeptide-8, Copper Palmitoyl Heptapeptide-14, Palmitoyl Sh-Hexapeptide-13 Serine Sp Amide, Hydrolyzed Collagen, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Lactic Acid Glycolic Acid Copolymer, Glycerin, Tocopherol, Pullulan, Lysolecithin, Sclerotium Gum, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Dimethicone, Sodium Phytate, Diglycerin, Hydrogenated Lecithin, Silica, Cetyl Alcohol, Hydroxyacetophenone, Polysorbate 60, Sorbitan Isostearate, Sodium Hydroxide, Sodium Benzoate, Potassium Sorbate, Polyvinyl Alcohol, Decyl Glucoside, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Citric Acid, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin (this page)
- Italy: https://lovi.care/skincare/it/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin