# MISSHA Time Revolution Night Repair Ampoule 5X for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [MISSHA](https://lovi.care/skincare/fr/brands/missha)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as niacinamide helps regulate oil production and glycerin provides hydration, supporting general skin health for acne and blemishes.
- The blend of bifida ferment lysate and various lactobacillus ferments enhances skin barrier resilience and offers soothing benefits, contributing to overall skin improvement.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule-5x/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule-5x/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule-5x/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule-5x/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule-5x/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule-5x/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule-5x/for/oily-acne-prone-skin): Average

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Sodium Hyaluronate, Squalane, Extreme Biome

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Users consistently praise this ampoule as a powerful anti-aging treatment that delivers deep hydration and a "glass skin" glow overnight, often comparing it favorably to the much more expensive Estée Lauder Advanced Night Repair. It is particularly effective for dry, mature, and sensitive skin types, helping to smooth rough texture and plump fine lines, though a minority of users with sensitivities to fermented ingredients or essential oils experienced irritation.

- Liked: Hydration and glow (mostly mentioned)
- Liked: Estée Lauder dupe (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Disliked: Scent irritation (sometimes noted)
- Disliked: Breakouts or irritation (rarely noted)
- Disliked: Opaque packaging (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does MISSHA Night Repair Ampoule 5X work for acne-prone skin?

This treatment is an average fit for acne-prone skin, as niacinamide helps control oil and glycerin provides light hydration. Ferments like bifida lysate ferment help soothe the skin and strengthen its barrier with a low risk of irritation. For this skin type, a product needs effective ingredients like niacinamide and zinc or propolis that balance hydration and oil without causing breakouts.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum works for acne-prone skin because niacinamide helps balance oil production while glycerin provides gentle hydration. Additionally, bifida ferment lysate and various lactobacillus ferments strengthen the skin barrier and help calm the skin without causing irritation. For an even better fit, acne-prone skin needs targeted blemish-fighting ingredients like propolis or zinc PCA alongside balanced hydration that controls oiliness without causing dryness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### What does Bifida Ferment Lysate do for acne-prone skin?

Bifida Ferment Lysate helps acne-prone skin by calming redness and keeping the skin barrier strong. This ingredient may also support the skin's defenses against irritation, making it less likely to flare up.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in your evening routine after cleansing and toning, and before moisturizing. Acne-prone skin of this type needs products featuring niacinamide to help regulate oil, glycerin for hydration, and soothing ferments to calm blemishes.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the serum first and letting it absorb before putting on your retinol. This product is unlikely to cause irritation due to its soothing ingredients, but acne-prone skin often does best with lightweight, oil-balancing ingredients and barrier-strengthening ferments.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. Acne-prone skin needs products with niacinamide to help regulate oil, glycerin for hydration, and soothing fermented ingredients like bifida ferment lysate.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36798538/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for acne-prone skin, as it has a low risk of causing blemishes and contains soothing ingredients. However, because it offers only an average fit for this skin type, acne-prone skin typically needs lighter formulas with ingredients like niacinamide and salicylic acid to better control oil and keep pores clear.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (limonene).

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — €18.25 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/fr/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €35.99 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €139.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/fr/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.98 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/fr/p/la-mer/the-tonic/for/acne-prone-skin) — Superior fit — €10.25 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/fr/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €17.90 at Amazon

## Where to buy

- Amazon.fr: €26.09 (https://www.amazon.fr/dp/B09648RPKJ?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Notino: €53.90 (https://www.notino.fr/missha/time-revolution-night-repair-ampoule-5x-soin-de-nuit-intense-effet-anti-rides/p-16145762/)
Prices checked 27 Oct – 6 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Butylene Glycol, Glycerin, Propanediol, Betaine, Water, Niacinamide, Pentylene Glycol, 1,2-Hexanediol, Diethoxyethyl Succinate, Chondrus Crispus Extract, Squalane, Panthenol, Polyglyceryl-10 Laurate, Saccharum Officinarum Extract, Hydrogenated Lecithin, Carbomer, Tromethamine, Xanthan Gum, Polyquaternium-51, Ethylhexylglycerin, Adenosine, Dextrin, Theobroma Cacao Extract, Bergamot Oil Fruit, Disodium Edta, Sodium Hyaluronate, Lactobacillus Ferment, Lactobacillus Lysate Ferment, Bifida Ferment Filtrate, Lactobacillus Acerola Cherry Ferment, Lactobacillus Punica Granatum Extract Fruit Ferment, Lactobacillus Soybean Extract Ferment, Lactococcus Ferment, Lactococcus Lysate Ferment, Leuconostoc Radish Root Ferment Filtrate, Pelargonium Graveolens Oil Flower, Beta Vulgaris Root Extract, Brassica Oleracea Capitata Leaf Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Solanum Melongena Fruit Extract, Blueberry Fruit Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Citrus Aurantium Dulcis Peel Oil, Lavandula Angustifolia Oil Lavender Oil, Lupinus Albus Seed Extract, Aspergillus Ferment, Swiftlet Nest Extract, Anthemis Nobilis Oil Flower, Sandalwood Oil, Tocopherol, Ceramide Np, Cholesterol, Limonene
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin (this page)
- Italy: https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin