# Medimine Phyto Enzyme Powder Wash for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: Medimine
Category: [Exfoliants](https://lovi.care/skincare/fr/best/exfoliators)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few products fit it even better.

## Why this fit

- Offers excellent cleansing and exfoliation for your combination skin, as papain and sodium cocoyl isethionate work to clear pores and regulate sebum, addressing your oily shine. Niacinamide further supports sebum control and provides a soothing effect, enhancing the product's suitability for your skin type.
- Chamomilla Recutita Flower Extract and Glycyrrhiza Glabra Root Extract contribute to a gentle experience, minimizing irritation potential for your combination skin.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/oily-acne-prone-skin): Superior

## Key ingredients

Papain, Pearl Extract, Niacinamide, Licorice Root Extract, Chamomile Flower Extract

## What the research says

- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Sodium cocoyl isethionate micelles are too large to penetrate stratum corneum aqueous pores, resulting in significant steric hindrance that prevents skin barrier perturbation and explains its skin mildness. ([Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/17598025/))
- Apigenin protects against UVA-induced cytotoxicity and senescence in normal human dermal fibroblasts, decreases MMP-1 expression, and when applied topically as a cream in human subjects, increases dermal density and elasticity while reducing fine wrinkle length, skin evenness, moisture content, and transepidermal water loss compared to control cream. ([International Journal of Molecular Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/27279007/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))
- Carica papaya leaf extracts obtained via supercritical fluid and conventional methods demonstrated antioxidant and cytoprotective effects on skin fibroblasts against oxidative stress, driven by their respective lipophilic and hydrophilic constituents. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33803330/))
- Micro and nanosized pearl powders increased skin cell proliferation and migration, accelerated wound closure, enhanced biomechanical strength, improved collagen deposition, and promoted angiogenesis in rats, with nanoscale pearl powder showing the highest efficiency. ([Drug Development and Industrial Pharmacy, 2019](https://pubmed.ncbi.nlm.nih.gov/30950303/))
- Topical pearl extract gel inhibited UV-irritated skin wrinkles, laxity, thickness, and dryness, upregulated antioxidant enzyme activities, decreased MDA levels, and suppressed inflammatory factors in UV-irradiated mice compared to untreated controls, with high-dose PEG showing superior effects to Vitamin E. ([Chemistry & Biodiversity, 2022](https://pubmed.ncbi.nlm.nih.gov/35098641/))
- Seawater pearl powder treatment significantly improves UV-induced photoaging and restores skin tissue structure in mice by reducing MMP-1, enhancing collagen I, inhibiting the MAPK signaling pathway, and scavenging reactive oxygen species. ([Evidence-based Complementary and Alternative Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34925534/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical chamomile oil combined with a night splint significantly improved the symptomatic and functional status of patients with severe carpal tunnel syndrome compared to placebo, while electrodiagnostic parameters showed no significant changes. ([Complementary Therapies in Clinical Practice, 2015](https://pubmed.ncbi.nlm.nih.gov/26573447/))
- German chamomile solution applied twice a day healed peristomal skin lesions significantly faster than once-a-day 1% hydrocortisone ointment in colostomy patients, with a mean healing time of 8.89 days versus 14.53 days. ([Ostomy/wound Management, 2011](https://pubmed.ncbi.nlm.nih.gov/21617262/))
- Topical chamomile reduces the incidence and delays the occurrence of phlebitis due to amiodarone infusion in coronary care patients compared to a placebo of lanoline. ([Journal of Integrative Medicine, 2017](https://pubmed.ncbi.nlm.nih.gov/28844214/))

## What reviewers say

Based on limited data, users generally praise this powder wash for its ability to dramatically improve skin texture and brightness without causing tightness, often describing it as a "holy grail" for smoothing rough skin. However, experiences are polarized regarding sensitivity; while many find it gentle, a minority report significant irritation and redness, and some struggle with the powder packaging.

- Liked: Smoothes skin texture (mostly mentioned)
- Liked: Brightening effect (often mentioned)
- Liked: Non-stripping (often mentioned)
- Liked: Clears bumps/acne (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: High price (rarely noted)
- Disliked: Makeup removal (rarely noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Could be used as part of your PM routine once a week. Start 3x/week and build up to daily use if your skin tolerates it well.
- Apply the enzyme powder cleanser after your regular cleanser and toner, but before your moisturizer.
- Pour a small amount into wet hands and rub together to create a creamy foam, then massage gently onto the face.
- Apply the enzyme powder cleanser on slightly damp skin to help activate the gentle exfoliating enzymes.
- Avoid the eye area and do a patch test before your first use to ensure your skin feels comfortable.
- Video: https://storage.pora.ai/2d8db6e67371d665a6a7736b5ed5d762.mp4

## Questions and answers

### What makes Medimine Phyto Enzyme Powder Wash a great fit for combination skin?

Medimine Phyto Enzyme Powder Wash is a great fit for your combination skin because papain and sodium cocoyl isethionate clear pores and help control oily shine. Niacinamide, licorice root extract, and chamomile flower extract further soothe your skin and keep the cleansing experience gentle.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/17598025/)

### Which ingredients make this cleanser a good fit for combination skin?

Papain and sodium cocoyl isethionate help clear pores and control oily shine, while niacinamide and licorice root extract soothe the skin. Chamomile flower extract further keeps the experience gentle and helps prevent irritation on your combination skin.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/17598025/)

### What does Papain do for combination skin?

Papain gently exfoliates the skin by breaking down dead surface proteins, which helps keep oily and dry areas balanced and smooth. It is unlikely to cause severe irritation when used properly, though mild tingling may occur.
Sources: [International Journal of Cosmetic Science, 2022](https://pubmed.ncbi.nlm.nih.gov/35892222/)

### What does Pearl Extract do for combination skin?

Pearl extract helps brighten combination skin and evens out tone by slowing down the processes that create dark spots. It is unlikely to feel heavy on oily areas while still supporting a smooth and balanced look.
Sources: [International Journal of Molecular Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/37108635/), [Journal of Drugs in Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33683078/)

### Where does this cleanser go in a skincare routine for combination skin?

Medimine Phyto Enzyme Powder Wash is used as a cleanser in both morning and evening routines, and it also works well as a weekly exfoliating step. It helps clear pores and regulate oily shine without irritating your skin.

### Can I use it with retinol, and in what order?

You can use this enzyme powder cleanser alongside retinol, but it is best to use them on different days or times to keep your skin calm and avoid irritation.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/)

### How often should I use this cleanser?

Start by using this enzyme powder once a week as part of your weekly routine. People who tolerate it well and see good results can carefully use it more often.

### Can it clog pores, cause breakouts or purging for combination skin?

Medimine Phyto Enzyme Powder Wash is unlikely to clog pores or cause breakouts for your combination skin. Its gentle ingredients and enzymes help clear pores and regulate oily shine without irritating your skin.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/17598025/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [NEEDLY Mild Enzyme Cleansing Powder](https://lovi.care/skincare/fr/p/needly/mild-enzyme-cleansing-powder/for/combination-skin) — High fit — €39.00 at Amazon
- [Tatcha The Rice Polish: Gentle](https://lovi.care/skincare/fr/p/tatcha/the-rice-polish-gentle/for/combination-skin) — High fit — €149.72 at Amazon
- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/fr/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/combination-skin) — Average fit — €16.71 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice RESIST Perfectly Balanced Foaming Cleanser](https://lovi.care/skincare/fr/p/paula-s-choice/perfectly-balanced-foaming-cleanser/for/combination-skin) — Superior fit — €32.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/fr/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/fr/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €17.47 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Zea Mays Starch, Sodium Cocoyl Isethionate, Sodium Lauroyl Glutamate, Sorbitol, Papain, Pearl Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Allantoin, Citric Acid, Disodium Edta, Isopropyl Palmitate, Niacinamide, Betaine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medimine/phyto-enzyme-powder-wash/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medimine/phyto-enzyme-powder-wash/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/medimine/phyto-enzyme-powder-wash/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/combination-skin
- France: https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/combination-skin (this page)
- Italy: https://lovi.care/skincare/it/p/medimine/phyto-enzyme-powder-wash/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/medimine/phyto-enzyme-powder-wash/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/medimine/phyto-enzyme-powder-wash/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/medimine/phyto-enzyme-powder-wash/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medimine/phyto-enzyme-powder-wash/for/combination-skin