# Medik8 Oxy-R Peptides for oily skin

**Lovi Fit: High fit for oily skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Medik8](https://lovi.care/skincare/fr/brands/medik8)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin brightening for your oily skin due to Hydroxyresveratrol and Tetrapeptide-30, which promote evening skin tone and address oily shine. Gluconolactone and Lactic Acid provide moderate chemical exfoliation, helping to manage excess oil and improve skin texture.
- The formula is highly suitable for oily skin, with Gluconolactone and Lactic Acid offering keratolytic and humectant actions respectively.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of harsh ingredients and the presence of soothing agents like Hydroxyresveratrol and Glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/oily-skin): High (this page)
- [Dry skin](https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin): High

## Key ingredients

Oxyresveratrol, Peptides, Sodium Hyaluronate, Lactic Acid, Glycerin

## What the research says

- Topical application of mulberroside A, oxyresveratrol, and oxyresveratrol-3-O-glucoside reduced UVB-induced skin pigmentation and melanogenic enzyme expression in brown guinea pigs compared to vehicle control, with oxyresveratrol showing the greatest effect. ([Food and Chemical Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/21946069/))
- Combining 10% gluconolactone chemical peeling with oxybrasion or microneedle mesotherapy increased skin hydration and decreased sebum, pH, and TEWL in twenty-one Caucasian women, with no significant differences between the two methods. ([Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/))
- Application of a new brightening complex cream containing niacinamide, tranexamic acid, oxyresveratrol, glutathione disulfide, and linoleic acid for 12 weeks increased skin lightness (L*-value) and significantly decreased melanin index and erythema index in Korean women. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28512843/))
- Topical oxyresveratrol microemulsion at 20-30% w/w effectively delayed skin lesion development and protected mice from death compared to untreated controls. ([AAPS PharmSciTech, 2012](https://pubmed.ncbi.nlm.nih.gov/22996670/))
- Encapsulating dihydrooxyresveratrol and oxyresveratrol into nanostructured lipid carriers enhanced photostability, promoted controlled release, facilitated skin penetration, exhibited no cytotoxicity up to 500 µg/mL on human keratinocytes, and effectively reduced melanogenesis in B16F10 cells. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39587280/))
- Oxyresveratrol alleviates ultraviolet B-induced cytotoxicity and inflammation in keratinocytes by exhibiting antioxidant activity, inhibiting p38 MAPK and AP-1, and decreasing the Bax/Bcl-2 ratio. ([Heliyon, 2024](https://pubmed.ncbi.nlm.nih.gov/39469685/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## What reviewers say

Based on a very large amount of data, users with hyperpigmentation, melasma, and post-inflammatory erythema (PIE) frequently report visible skin brightening and the fading of dark spots, often noting a smoother texture and "glass-like" glow within weeks. While many experience rapid results, a minority of users report no visible changes or mild breakouts, and the short shelf life of the activated formula is a noted consideration.

- Liked: Fades dark spots (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Gentle formulation (sometimes noted)
- Liked: Rapid results (sometimes noted)
- Disliked: Ineffective for some (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Short shelf life (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medik8 Oxy-R Peptides a great fit for oily skin?

Medik8 Oxy-R Peptides is a great fit because it brightens uneven skin tone and manages oily shine using oxyresveratrol and peptides. It also provides gentle chemical exfoliation to clear excess oil and improve skin texture, while soothing agents help prevent irritation.
Sources: [Food and Chemical Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/21946069/), [Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/)

### Which ingredients make this serum a good fit for oily skin?

Hydroxyresveratrol and Tetrapeptide-30 make this serum a great fit by brightening tone and helping manage oily shine, while Gluconolactone and Lactic Acid gently exfoliate to keep texture smooth and clear. Glycerin also helps draw in light hydration without feeling heavy.
Sources: [Food and Chemical Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/21946069/), [Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/)

### What does Oxyresveratrol do for oily skin?

Oxyresveratrol is an antioxidant that helps calm the skin and reduce dark spots by slowing down pigment production. This ingredient is often paired with gentle hydrators and oil-balancing agents to keep oily skin clear and smooth.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28512843/), [Molecules, 2018](https://pubmed.ncbi.nlm.nih.gov/29300356/)

### What do Peptides do for oily skin?

Peptides help support skin health and may improve the look of oily skin, but this type of skin needs formulas with ingredients that balance oil production and keep pores clear.
Sources: [Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40565185/)

### Where does this serum go in a skincare routine for oily skin?

This treatment serum goes in your evening routine, applied after cleansing and before your moisturizer. Putting this product in the evening step keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

This treatment can be used alongside retinol, but it is best to apply them on alternate nights or separate them into your morning and evening routines to avoid overloading your skin. Using them together carefully helps prevent irritation while still managing oily shine and improving your skin texture.

### How often should I use this serum?

Medik8 Oxy-R Peptides is a great fit for your oily skin and works well as an evening treatment. Start using it once a week as part of your routine, and if your skin feels comfortable and looks good, you may carefully use it more often. The gentle ingredients help manage excess oil and brighten your tone without causing irritation.
Sources: [Food and Chemical Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/21946069/), [Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/)

### Can this serum clog pores, cause breakouts or purging for oily skin?

This serum is unlikely to clog pores or cause breakouts for oily skin, as it has a very safe formula with soothing ingredients like glycerin and hydroxyresveratrol. Breakouts are only rarely reported by reviewers, and gentle exfoliating acids help manage excess oil.
Sources: [Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-skin) — Superior fit — €18.25 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/fr/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/oily-skin) — Superior fit — €35.99 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — €139.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/fr/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — €11.35 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/fr/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — €19.99 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/fr/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — €17.47 at Amazon

## Where to buy

- Amazon.fr: €75.95 (https://www.amazon.fr/dp/B093R4NDJS?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Notino: €76.00 (https://www.notino.fr/medik8/oxy-r-peptides-serum-intense/p-16151739/)
Prices checked 26 Oct – 5 Nov 2026.

## Ingredients

Water, Butylene Glycol, Artocarpus Lakoocha Extract Wood, Hydroxyresveratrol, Gluconolactone, Acetyl Glycyl Beta-Alanine, Glycerin, Lactic Acid, Sodium Hyaluronate, Sodium Benzoate, Disodium Edta, Tetrapeptide-30, Xanthan Gum, Sodium Metabisulfite, Calcium Gluconate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medik8/oxy-r-peptides/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/medik8/oxy-r-peptides/for/oily-skin
- France: https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/oily-skin (this page)
- Italy: https://lovi.care/skincare/it/p/medik8/oxy-r-peptides/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/medik8/oxy-r-peptides/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/medik8/oxy-r-peptides/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/medik8/oxy-r-peptides/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/medik8/oxy-r-peptides/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medik8/oxy-r-peptides/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medik8/oxy-r-peptides/for/oily-skin