# Medik8 CRYSTAL RETINAL 6 for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/fr/p/medik8/crystal-retinal-6/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Medik8](https://lovi.care/skincare/fr/brands/medik8)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate rejuvenation for your combination skin, as retinaldehyde and hyaluronic acid promote cell turnover and hydration, which can help manage oily shine.
- Hyaluronic acid and vitamin E provide general hydration and antioxidant protection, supporting your skin's overall health.
- The formula is safe for your combination skin, containing no harsh ingredients and including soothing components like hyaluronic acid and vitamin E.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/medik8/crystal-retinal-6/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/medik8/crystal-retinal-6/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/fr/p/medik8/crystal-retinal-6/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/fr/p/medik8/crystal-retinal-6/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/medik8/crystal-retinal-6/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/medik8/crystal-retinal-6/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/medik8/crystal-retinal-6/for/mature-skin): Low
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/medik8/crystal-retinal-6/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/medik8/crystal-retinal-6/for/oily-acne-prone-skin): Average

## Key ingredients

Retinaldehyde Vitamin A, Hyaluronic Acid, Tocopherol Vitamin E, Squalane, Glycerin

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index. ([Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29663701/))
- Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance. ([Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12218231/))
- Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients. ([Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473959/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## What reviewers say

Based on a very large amount of data, users consistently praise this serum as a "game-changer" for smoothing texture and brightening dull complexions without the harsh irritation often associated with retinoids. It is frequently recommended for those with acne-prone or sensitive skin who want to target fine lines and congestion, with many reporting "glass skin" results and visibly clearer pores within weeks.

- Liked: Gentle yet effective (mostly mentioned)
- Liked: Improves skin texture (mostly mentioned)
- Liked: Clears acne & congestion (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Brightening & firming (sometimes noted)
- Liked: Pleasant user experience (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Yellow staining (sometimes noted)
- Disliked: Mild dryness/purging (rarely noted)
- Disliked: Scent preference (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medik8 Crystal Retinal 6 work for combination skin?

Medik8 CRYSTAL RETINAL 6 works moderately well for your combination skin, offering cell turnover and hydration that may help manage oily shine while remaining safe and gentle. Treatment products for this skin need effective ingredients like niacinamide, propolis, or zinc PCA to regulate oiliness, enhance radiance, and provide balanced hydration.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Which ingredients make this serum a good fit for combination skin?

Retinaldehyde and hyaluronic acid make this serum a good fit for your combination skin by promoting cell turnover and hydration, which can help manage oily shine. This product needs ingredients like niacinamide and zinc PCA to better balance oiliness and maintain skin health without excess shine.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Retinaldehyde do for combination skin?

Retinaldehyde helps smooth and firm combination skin while improving the look of fine lines and texture. It is unlikely to cause irritation when used regularly, making it a well-tolerated choice for skin that can be both oily and dry.
Sources: [Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473963/), [Journal of Drugs in Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39496127/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this serum go in a skincare routine for combination skin?

Apply this treatment in the evening after cleansing and before moisturizing. A treatment of this type needs balancing ingredients like hyaluronic acid and soothing vitamin E to keep combination skin hydrated while managing oily shine.

### Can I use this serum with niacinamide, and in what order?

You can use this treatment with niacinamide by applying niacinamide first and following with this treatment once it absorbs, or by using niacinamide in your morning routine and this treatment at night. This approach helps manage oily shine while keeping your skin calm and hydrated.
Sources: [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### How often should I use this serum?

This treatment works well for your combination skin in the evening routine, where you can start slowly. A product of this type needs soothing hydrators and gentle cell-renewing ingredients to manage oily shine safely.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This treatment is unlikely to cause breakouts, but mild purging or dryness may happen when you start using it. To care for combination skin properly, a product of this type needs lightweight hydrators like hyaluronic acid and glycerin to balance oily shine without heavy oils.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — €18.25 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/fr/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €35.99 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/fr/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €389.34 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice RESIST Perfectly Balanced Foaming Cleanser](https://lovi.care/skincare/fr/p/paula-s-choice/perfectly-balanced-foaming-cleanser/for/combination-skin) — Superior fit — €32.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/fr/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/fr/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €17.47 at Amazon

## Where to buy

- Amazon.fr: €87.30 (https://www.amazon.fr/dp/B09CKHKP75?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €86.00 (https://www.lookfantastic.fr/p/medik8-crystal-retinal-6/11899386/)
- Notino: €88.90 (https://www.notino.fr/medik8/crystal-retinal-6-serum-anti-rides-hydratant-intense-aux-vitamines-a-et-e/p-16088857/)
Prices checked 10 Oct – 5 Nov 2026.

## Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Cetearyl Alcohol, Dimethicone, Hydrogenated Polydecene, Cetearyl Olivate, Sorbitan Olivate, Retinaldehyde, Hyaluronic Acid, Tocopherol Vitamin E, Phenoxyethanol, Ethylhexylglycerin, Carbomer, Sodium Hydroxide, Disodium Edta, Lecithin, Squalane, Glyceryl Stearate, Peg-100 Stearate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medik8/crystal-retinal-6/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medik8/crystal-retinal-6/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/medik8/crystal-retinal-6/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/medik8/crystal-retinal-6/for/combination-skin
- France: https://lovi.care/skincare/fr/p/medik8/crystal-retinal-6/for/combination-skin (this page)
- Italy: https://lovi.care/skincare/it/p/medik8/crystal-retinal-6/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/medik8/crystal-retinal-6/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/medik8/crystal-retinal-6/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/medik8/crystal-retinal-6/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/medik8/crystal-retinal-6/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/medik8/crystal-retinal-6/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medik8/crystal-retinal-6/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medik8/crystal-retinal-6/for/combination-skin