# Medicube Zero Pore Cream 2.0 for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Medicube](https://lovi.care/skincare/fr/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate pore treatment and hydration for your normal skin, as niacinamide and centella asiatica extract help minimize pores and soothe, while glycerin and panthenol provide humectant and barrier repair benefits.
- While beneficial for general skin health, the formula does not specifically target your concerns of wrinkles and fine lines.
- The product is safe for your normal skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like niacinamide and centella asiatica extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Salicylic Acid, Sodium Hyaluronate, Willow Bark Extract, Oil Tree

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- Topical lycopene-enriched virgin olive oil provides effective pain relief similar to a placebo in patients with burning mouth syndrome, showing a strong placebo effect. ([Journal of Oral Rehabilitation, 2014](https://pubmed.ncbi.nlm.nih.gov/24612248/))

## Why other serums fit mature skin better

- Topical application of retinol and retinoic acid both increased epidermal thickness and upregulated collagen genes and proteins in human skin, with retinol producing similar histological and molecular changes to retinoic acid alongside a significant reduction in facial wrinkles after 12 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26578346/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))

## What reviewers say

Based on a very large amount of data, users with combination and oily skin frequently praise this cream for its ability to balance sebum production while providing deep hydration without a sticky finish. Many report smoother skin texture and a fresh feeling. However, a significant number of reviewers note that visible reduction in pore size is subtle or non-existent despite the product's claims.

- Liked: Excellent hydration (mostly mentioned)
- Liked: Pleasant texture (often mentioned)
- Disliked: Ineffective on pores (often mentioned)
- Liked: Sebum control (sometimes noted)
- Liked: Skin smoothing (sometimes noted)
- Disliked: Strong scent (sometimes noted)
- Disliked: Heavy for some (rarely noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does medicube Zero Pore Cream work for mature skin?

This cream works moderately well for mature skin, providing good hydration and soothing care, but it does not specifically target wrinkles and fine lines. To truly care for mature skin, a product needs potent antioxidants, high-performing anti-aging ingredients, and powerful hydrating components that smooth fine lines while keeping the skin safe from irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for mature skin?

This cream fits mature skin through ingredients like niacinamide, sodium hyaluronate, and glycerin, which help improve moisture and support skin health. However, a product for this skin also needs potent anti-aging ingredients and powerful antioxidants to target wrinkles and fine lines.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Salicylic Acid do for mature skin?

Salicylic acid helps smooth and firm mature skin by boosting collagen and elasticity while reducing roughness and wrinkles. It is unlikely to cause irritation when used correctly, but this skin type also needs extra hydrating ingredients to stay soft and plump.
Sources: [Aesthetic Plastic Surgery, 2025](https://pubmed.ncbi.nlm.nih.gov/38926250/)

### Where does this cream go in a skincare routine for mature skin?

This treatment goes in your evening routine, as Lovi routines place treatments in the evening for simplicity and extra safety around sun exposure. A product for mature skin needs ingredients like retinoids, peptides, or antioxidants to target wrinkles and fine lines.

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol, but apply your retinol first and follow with this treatment to keep your skin calm and hydrated. Because this product does not specifically target wrinkles and fine lines, mature skin needs a formula packed with antioxidants, peptides, and rich hydrators to smooth and firm.

### How often should I use this cream?

You can use this treatment in the evening as part of your routine. A product of this type needs firming and smoothing ingredients like retinol, peptides, and antioxidants to properly care for mature skin.

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to cause breakouts or clog pores on mature skin, as it has a very low risk of irritation and uses soothing ingredients like niacinamide and centella asiatica extract. However, because it can feel heavy for some users, mature skin may benefit more from products featuring targeted anti-aging ingredients like retinol and peptides to smooth out wrinkles and fine lines.

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €139.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/fr/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — €599.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/fr/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €76.29 at Amazon

## Where to buy

- Amazon.fr: €24.50 (https://www.amazon.fr/dp/B0DKXDGMLZ?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Notino: €37.00 (https://www.notino.fr/medicube/zero-pore-cream-2-0-creme-hydratante-visage-pour-reduire-les-pores/p-16359270/)
Prices checked 17 Oct – 5 Nov 2026.

## Ingredients

Water, Glycerin, Niacinamide, Butylene Glycol, Cyclopentasiloxane, Dimethicone, Cyclohexasiloxane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Polysorbate 80, Squalane, Tocopheryl Acetate, Panthenol, Allantoin, Centella Asiatica Extract, Camellia Sinensis Leaf Extract, Portulaca Oleracea Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Scutellaria Baicalensis Root Extract, Polygonum Cuspidatum Root Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Coptis Japonica Root Extract, Adenosine, Ethylhexylglycerin, Caprylyl Glycol, 1,2-Hexanediol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-pore-cream-2-0/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-pore-cream-2-0/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-pore-cream-2-0/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/medicube/zero-pore-cream-2-0/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-pore-cream-2-0/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-pore-cream-2-0/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-pore-cream-2-0/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-pore-cream-2-0/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-pore-cream-2-0/for/mature-skin