# Medicube Triple Collagen Serum 4.0 for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Medicube](https://lovi.care/skincare/fr/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your dry skin, as glycerin and sodium hyaluronate provide humectant action to address dryness and flakiness. The multiple forms of collagen and sodium hyaluronate in moderate concentrations will offer excellent plumping and elasticity improvement.
- The formula provides general hydration benefits, though it lacks sufficient emollient ingredients for optimal hydration of dry skin.
- The product is generally safe for your dry skin, with some risks of irritation due to the presence of alcohol denat and fragrance.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin): Average

## Key ingredients

Collagen Extract, Sodium Hyaluronate, Niacinamide, Adenosine, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Ethanol as a preservative in topical creams reduced the dermal penetration of hydrophilic surrogates by about 40% and lipophilic surrogates by about 20% on intact skin while having minimal impact on irritated skin, and it altered biophysical skin properties depending on the skin condition. ([Pharmaceutics, 2025](https://pubmed.ncbi.nlm.nih.gov/40006563/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## Why other serums fit dry skin better

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))

## What reviewers say

Users consistently praise this serum for delivering a "glass skin" finish and deep hydration, making it a favorite for those with dry, dull, or mature skin. While the plumping and glow-boosting effects are widely celebrated, some users with oily or sensitive skin find the formula slightly sticky or the fragrance too strong.

- Liked: Glass skin glow (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Makeup compatibility (sometimes noted)
- Liked: Silky texture (sometimes noted)
- Disliked: Added fragrance (sometimes noted)
- Disliked: Sticky or heavy (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Price vs. quantity (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medicube Triple Collagen Serum work for dry skin?

Medicube Triple Collagen Serum works moderately well for dry skin, as glycerin and sodium hyaluronate help draw in moisture and plump the skin. However, it lacks enough rich, softening ingredients to fully soothe very dry skin and includes alcohol and fragrance that may cause irritation. A product for this skin needs rich, softening ingredients and skin-repairing nourishers like ceramides, peptides, and soothing plant extracts to lock in hydration without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry skin?

Glycerin and sodium hyaluronate make this serum a fit for dry skin by acting as hydrators to tackle dryness and flakiness, while multiple forms of collagen help improve plumpness and elasticity. However, because this dry skin needs a product of this type to include rich smoothing ingredients, barrier-supporting elements like ceramides, and soothing additions like propolis or bifida ferment, other treatments fit it better.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Collagen Extract do for dry skin?

Collagen Extract helps keep dry skin hydrated and improves its elasticity. Studies show that using collagen regularly can boost skin moisture and make it feel much softer and smoother.
Sources: [Skin Pharmacology and Physiology, 2012](https://pubmed.ncbi.nlm.nih.gov/22270036/), [Journal of Drugs in Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30681787/)

### What does Hyaluronic Acid do for dry skin?

Hyaluronic acid draws moisture into dry skin, giving an immediate and lasting boost in hydration that helps smooth out fine lines and soften rough patches. It is very gentle and unlikely to cause irritation while improving overall skin smoothness and plumpness.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this serum go in a skincare routine for dry skin?

This treatment serum goes in your evening routine after cleansing and before moisturizing, though dry skin of this type needs richer softening and sealing ingredients to lock in hydration fully.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to deliver hydration, followed by your retinol. This product helps plump dry skin with collagen and sodium hyaluronate, though it may carry some risk of irritation due to alcohol and fragrance.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. While it offers moderate hydration, dry skin of this type needs richer, softening ingredients and heavier moisturizing creams to stay truly smooth and comfortable.

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores or cause breakouts for dry skin, though alcohol denat and fragrance may cause some irritation. To keep dry skin feeling comfortable and smooth, this skin type needs rich oils and butters to lock in moisture.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (linalool, limonene, geraniol, citronellol, citral, and benzyl alcohol) and drying alcohol (alcohol denat).

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — €18.25 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €29.58 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/fr/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €7.50 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/propolis-synergy-toner/for/dry-skin) — Superior fit — €18.55 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/fr/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-skin) — Superior fit — €76.29 at Amazon

## Where to buy

- Amazon.fr: €16.60 (https://www.amazon.fr/dp/B085VWWJJT?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €20.59 (https://www.lookfantastic.fr/p/medicube-triple-collagen-serum-4.0-55ml/16858546/)
- Notino: €27.50 (https://www.notino.fr/medicube/triple-collagen-serum-serum-raffermissant-au-collagene/p-16304405/)
Prices checked 10 Oct – 4 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Cetyl Ethylhexanoate, Niacinamide, Glycereth-26, Alcohol Denat, 2-Hexanediol, Cyclopentasiloxane, Cyclohexasiloxane, Trehalose, Dimethicone, Carbomer, Cetearyl Olivate, Tromethamine, Sorbitan Olivate, Ethylhexylglycerin, Collagen Extract, Adenosine, Disodium Edta, Benzyl Benzoate, Linalool, Limonene, Geraniol, Atelocollagen, Desamido Collagen, Citronellol, Hydrolyzed Collagen, Sodium Hyaluronate, Water-Soluble Collagen, Hydroxycitronellal, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Collagen, Collagen Amino Acids, Sodium Acetylated Hyaluronate, Procollagen, Hydroxypropyltrimonium Hyaluronate, Citral, Benzyl Alcohol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/triple-collagen-serum-4-0/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/triple-collagen-serum-4-0/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/triple-collagen-serum-4-0/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/dry-skin
- France: https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/dry-skin (this page)
- Italy: https://lovi.care/skincare/it/p/medicube/triple-collagen-serum-4-0/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/triple-collagen-serum-4-0/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/medicube/triple-collagen-serum-4-0/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/triple-collagen-serum-4-0/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/medicube/triple-collagen-serum-4-0/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum-4-0/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum-4-0/for/dry-skin