# Medicube Super Cica Ampoule for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Medicube](https://lovi.care/skincare/fr/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your normal skin is provided by Centella Asiatica Extract and Glycerin, which offer anti-inflammatory and humectant actions respectively, addressing your concerns about wrinkles and fine lines.
- The moderate concentrations of Centella Asiatica Extract and Madecassoside further support skin repair and collagen production, enhancing the treatment of fine lines and wrinkles.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like Centella Asiatica Extract and Madecassoside.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica Extract, Madecassoside, Asiatic Acid, Madecassic Acid, Extract Tree

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Chitosan-based hydrogels loaded with asiaticoside-rich Centella asiatica extract achieved controlled drug release, skin permeability, antimicrobial activity, and synergistic wound healing effects in an in vitro model. ([International Journal of Molecular Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/38139059/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))

## What reviewers say

This ampoule is highly effective for users with acne-prone and sensitive skin, frequently noted for its rapid soothing of redness and calming of active breakouts, acting as a significant aid for compromised skin barriers. A notable portion of users express dissatisfaction with its sticky or tacky finish, which can be problematic for morning routines and makeup application.

- Liked: Soothing & calming (mostly mentioned)
- Liked: Acne & blemish care (often mentioned)
- Disliked: Small quantity/price (often mentioned)
- Disliked: Sticky texture (often mentioned)
- Liked: Hydration & glow (sometimes noted)
- Disliked: Packaging/dropper issues (sometimes noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medicube Super Cica Ampoule a great fit for mature skin?

Medicube Super Cica Ampoule is a great fit for mature skin because Centella Asiatica Extract and glycerin help smooth fine lines while keeping your skin calm and moisturized. Moderate amounts of madecassoside and Centella Asiatica Extract further support collagen production and skin repair, and the formula is unlikely to cause any irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

Centella Asiatica Extract and glycerin make this serum a great fit by keeping mature skin calm and full of moisture to help smooth out fine lines and wrinkles. Madecassoside and Centella Asiatica Extract further support skin repair and collagen production, and the product is very unlikely to cause irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Centella Asiatica Extract do for mature skin?

Centella Asiatica Extract helps mature skin by improving moisture, reducing moisture loss, and supporting collagen production to keep skin firm and smooth. It also provides antioxidant and calming benefits that help protect against everyday stress and visible signs of aging.
Sources: [Scientific Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34188145/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516082/)

### What does Madecassoside do for mature skin?

Madecassoside helps mature skin by supporting collagen production to keep skin firm and smooth while calming irritation. It is unlikely to cause irritation and may protect against signs of aging and sun damage.
Sources: [Journal of Medicinal Food, 2023](https://pubmed.ncbi.nlm.nih.gov/37976111/), [Annales Pharmaceutiques Francaises, 1995](https://pubmed.ncbi.nlm.nih.gov/7741425/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in your evening routine, applied after cleansing and before your moisturizer. Using it at night keeps things simple and avoids any extra sun sensitivity.

### Can I use it with retinol, and in what order?

Yes, you can use this treatment with retinol, applying the treatment first and following with your retinol. Because this product contains soothing ingredients like Centella Asiatica Extract and Madecassoside, it helps keep your skin calm and is unlikely to cause irritation when layered.

### How often should I use this serum?

This treatment is used in the evening as part of your routine. It is a great fit for your mature skin and helps smooth fine lines and wrinkles while keeping your skin calm and hydrated.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can it clog pores, cause breakouts or purging for mature skin?

This product is unlikely to clog pores, cause breakouts, or lead to purging on mature skin because it lacks harsh ingredients and contains soothing components like Centella Asiatica Extract and Madecassoside. It also has a very safe profile with little chance of causing irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €139.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/fr/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — €599.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/fr/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €76.29 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Centella Asiatica Extract, Water, Glycerin, Butylene Glycol, Methylpropanediol, Glycereth-26, 1,2-Hexanediol, Betaine, Licorice Root Extract, Carbomer, Tromethamine, Glycereth-25 Pca Isostearate, Ethylhexylglycerin, Dipotassium Glycyrrhizate, Allantoin, Glyceryl Acrylate Acrylic Acid Copolymer, Dipropylene Glycol, Panthenol, Gardenia Extract, Adenosine, Propanediol, Polyglyceryl-10 Oleate, Centella Asiatica Root Extract, Centella Asiatica Leaf Extract, Nelumbo Nucifera Extract, Pentylene Glycol, Tree Leaf Water, Madecassoside, Biosaccharide Gum-1, Extract Tree, Asiatic Acid, Madecassic Acid, Asiaticoside, Ectoin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/super-cica-ampoule/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/super-cica-ampoule/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/super-cica-ampoule/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/medicube/super-cica-ampoule/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/super-cica-ampoule/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medicube/super-cica-ampoule/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medicube/super-cica-ampoule/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/super-cica-ampoule/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/super-cica-ampoule/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/super-cica-ampoule/for/mature-skin