# Medicube PDRN Pink Peptide Ampoule for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Medicube](https://lovi.care/skincare/fr/brands/medicube)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Offers moderate benefits for your wrinkles and fine lines as the Peptide Complex and Adenosine promote collagen production and skin elasticity, while Hyaluronic Acid and Niacinamide hydrate and support your normal skin barrier. Ubiquinone and Salmon PDRN offer antioxidant protection and skin regeneration, though their concentrations may not be optimized for significant wrinkle reduction.
- The formulation is safe for your normal skin, with no reported risks of irritation due to the absence of harsh or prohibited ingredients.
- This product provides excellent moisturizing and treatment, addressing your primary concerns effectively.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Salmon Pdrn, Salmon Collagen Complex, Ubiquinone

## What the research says

- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of CoQ10 improves mitochondrial function in aging skin in vivo, combating cellular signs of aging caused by an age-dependent shift to a functionally anaerobic energy metabolism. ([BioFactors, 2008](https://pubmed.ncbi.nlm.nih.gov/19096122/))
- Encapsulating coenzyme Q10 in lipid nanoparticles for topical use improves skin compatibility, protects against degradation, increases skin penetration, and provides controlled release to counteract aging effects. ([Colloids and Surfaces. B, Biointerfaces, 2023](https://pubmed.ncbi.nlm.nih.gov/37574615/))
- Review of topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles highlights their improved bioavailability, chemical stability, skin absorption, and photoprotective effects. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34206935/))

## What reviewers say

Based on a very large amount of data, users consistently report that this ampoule delivers a "glass skin" effect, providing deep hydration and a noticeable plumping effect that benefits dry and aging skin. While it is widely praised for smoothing texture and soothing sensitive skin, results regarding blemish fading are mixed and take longer to appear.

- Disliked: Deep hydration (mostly mentioned)
- Disliked: Radiant glow (mostly mentioned)
- Disliked: Fast absorption (often mentioned)
- Liked: Noticeable fragrance (sometimes noted)
- Liked: Small volume (sometimes noted)
- Disliked: Soothing and gentle (sometimes noted)
- Liked: Minor breakouts (rarely noted)
- Liked: Slight stickiness (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does medicube PDRN Pink Peptide Ampoule work for mature skin?

This product works for mature skin by offering moderate hydration and support for fine lines through its peptide complex, adenosine, and hyaluronic acid, though its ingredients may not be optimized for significant wrinkle reduction. A moisturizing treatment for mature skin needs higher concentrations of effective anti-wrinkle and hydrating ingredients to deliver optimal results.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this serum a good fit for mature skin?

The Peptide Complex and Adenosine help smooth wrinkles and fine lines, while Hyaluronic Acid and Niacinamide hydrate and support the skin barrier. To be an even better fit for mature skin, a product of this type needs higher concentrations of regenerating ingredients like Salmon PDRN and Ubiquinone.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### What does Salmon Pdrn do for mature skin?

Salmon Pdrn helps mature skin by smoothing out fine lines, reducing redness, and improving overall elasticity and hydration. It supports skin renewal by encouraging collagen buildup and helping the skin barrier recover, making it look brighter and more even over time.
Sources: [International Journal of Cosmetic Science, 2013](https://pubmed.ncbi.nlm.nih.gov/23738607/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/)

### What does Salmon Collagen do for mature skin?

Salmon collagen helps improve hydration, elasticity, and firmness in mature skin while reducing the appearance of wrinkles and roughness. Daily supplementation may visibly smooth skin texture and support overall youthful qualities over time.
Sources: [Nutrients, 2018](https://pubmed.ncbi.nlm.nih.gov/29949889/), [International Journal of Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33742704/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening keeps things simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to hydrate and support your skin before putting on your retinol. Using a hydrating treatment like this helps prepare your skin and is unlikely to cause irritation since the formula is safe for normal skin. To get better results for mature skin, a product of this type needs higher concentrations of regenerating ingredients like Salmon PDRN and Ubiquinone to properly target wrinkles and fine lines.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

Use this serum in your evening routine for simplicity and extra safety around sun exposure. If your skin tolerates it well, you may use it more often, such as twice a day.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin as it has a safe formulation without harsh ingredients. Mature skin needing stronger anti-aging results typically benefits from products packed with higher concentrations of collagen-boosting peptides, retinol, and targeted antioxidants.

### Can I use this serum around the eyes or on my body?

This moisturizing treatment is safe for your normal skin, though products for mature skin typically need higher concentrations of active ingredients like peptides and antioxidants to effectively target wrinkles in delicate areas like around the eyes or on the body.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/fr/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin) — High fit — €26.77 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/fr/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/mature-skin) — Average fit — €17.99 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/fr/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/mature-skin) — Average fit — €22.00 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/fr/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — €24.00 at Amazon

## Where to buy

- Amazon.fr: €16.60 (https://www.amazon.fr/dp/B0DBF65JYY?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €21.60 (https://www.lookfantastic.fr/p/medicube-pdrn-pink-peptide-serum-30ml/17692818/)
- Notino: €7.00 (https://www.notino.fr/medicube/pdrn-pink-one-day-serum-serum-renovateur-visage-eclat-et-hydratation/p-16366425/)
Prices checked 16 Oct – 5 Nov 2026.

## Ingredients

Salmon Pdrn, Salmon Collagen Complex, Ubiquinone, Ocimum Tenuiflorum, Hyaluronic Acid, Niacinamide, Curcuma Longa Root Extract, Adenosine, Ocimum Sanctum Leaf Extract, Peptide Complex, Rose Pdrn Extract Rosa Damascena Sodium Dna Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin