# Medicube One Day Exosome Shot 2000 for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Medicube](https://lovi.care/skincare/fr/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your combination skin is provided by niacinamide for seboregulation and betaine salicylate for mild keratolytic action, which also offers moderate benefits for your acne, blemishes, and breakouts.
- Lactobacillus Extracellular Vesicles and panthenol further promote skin regeneration and hydration, enhancing the overall treatment efficacy.
- The product is safe for your skin as it contains no prohibited or harsh ingredients, minimizing irritation risks.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin): High

## Key ingredients

Lactobacillus Extracellular Vesicles, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Adenosine

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport. ([Biomaterials Advances, 2022](https://pubmed.ncbi.nlm.nih.gov/35929319/))
- A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides. ([Medicina Cutanea Ibero-latino-americana, 1986](https://pubmed.ncbi.nlm.nih.gov/3528709/))
- Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models. ([Metabolites, 2021](https://pubmed.ncbi.nlm.nih.gov/34436468/))
- Topical application of Bifidobacterium-fermented soy milk extract significantly restored elasticity and viscoelasticity, increased hyaluronic acid content, and improved hydration and thickness in mouse skin, and lessened the decrease in skin elasticity in human skin compared to baseline. ([Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/15608997/))
- Genistein and daidzein inhibited UVB-induced hydrogen peroxide production in keratinocytes acting as free radical scavengers with negligible skin disruption, whereas glycitein showed no protective activity. ([International Journal of Pharmaceutics, 2008](https://pubmed.ncbi.nlm.nih.gov/18761396/))
- A water-in-oil microemulsion vehicle significantly enhanced the intradermal delivery of genistein, daidzein, and biochanin A in excised guinea pig and Yucatan micropig skin, with genistein exhibiting the most marked increase in skin accumulation and effectively preventing UV irradiation-induced erythema formation. ([Chemical & Pharmaceutical Bulletin, 2010](https://pubmed.ncbi.nlm.nih.gov/20190449/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

This ampoule is highly praised for its ability to refine skin texture and minimize pores, leading to smoother skin and a glow. While a tingling sensation from spicules is frequently noted and can be uncomfortable for some, most users experience visible improvements in smoothness and reduced blackheads within weeks. Some users with sensitive skin may experience irritation or dryness.

- Liked: Smoother skin texture (mostly mentioned)
- Disliked: Prickly/tingling sensation (mostly mentioned)
- Liked: Pore tightening (often mentioned)
- Liked: Blackhead reduction (sometimes noted)
- Liked: Fast results (sometimes noted)
- Disliked: Can be drying (rarely noted)
- Disliked: Skin irritation/breakouts (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medicube Exosome Shot 2000 a great fit for acne-prone skin?

This product is a great fit for your acne-prone skin because niacinamide helps balance oil while betaine salicylate provides gentle exfoliation to help clear breakouts. Lactobacillus vesicles and panthenol further support skin recovery and keep your skin soft and hydrated. It is also formulated without harsh ingredients, which helps keep irritation risks low.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this treatment a good fit for acne-prone skin?

This treatment is a great fit for your acne-prone skin because niacinamide helps balance oil and betaine salicylate provides gentle exfoliation that helps with breakouts. Lactobacillus extracellular vesicles and panthenol also promote skin healing and keep your skin hydrated.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What do Lactobacillus Extracellular Vesicles do for acne-prone skin?

Lactobacillus extracellular vesicles may help calm acne-prone skin by reducing irritation and supporting the skin barrier. Because acne-prone skin needs to balance oil while avoiding inflammation, this type of product works best when it includes soothing agents and lightweight, non-clogging hydrators.
Sources: [Frontiers in Immunology, 2026](https://pubmed.ncbi.nlm.nih.gov/42643438/), [International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41175997/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### Where does this treatment go in a skincare routine for acne-prone skin?

This treatment goes in your evening routine, applied after cleansing and before your moisturizer. You can safely use it once a week to start, and if your skin tolerates it well, you may carefully use it more often.

### Can I use it with retinol, and in what order?

You can use this treatment alongside retinol by applying the retinol first and following with this product, or by alternating nights to keep your skin calm and minimize irritation risks. Because this formula contains gentle exfoliating ingredients and soothing panthenol, it helps manage breakouts while supporting skin hydration.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### How often should I use this treatment?

Use this treatment once a week in the evening routine to start, and carefully increase the frequency if your skin tolerates it well and shows good results. Niacinamide and betaine salicylate help balance oil and improve breakouts, while panthenol and other ingredients support hydration and skin regeneration.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can it clog pores, cause breakouts or purging for acne-prone skin?

Medicube One Day Exosome Shot 2000 is a great fit for acne-prone skin because it contains niacinamide to balance oil and betaine salicylate for gentle exfoliating action that helps keep pores clear. It is very unlikely to cause breakouts or clog pores since it has a very low complaint rate for skin irritation and contains no harsh ingredients.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — €18.25 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/fr/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €35.99 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €139.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/fr/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.98 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/fr/p/la-mer/the-tonic/for/acne-prone-skin) — Superior fit — €10.25 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/fr/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €17.90 at Amazon

## Where to buy

- Amazon.fr: €21.90 (https://www.amazon.fr/dp/B0GT52ZD5V?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €19.84 (https://www.lookfantastic.fr/p/medicube-one-day-exosome-shot-pore-ampoule-2000-30ml/16858542/)
- Notino: €27.50 (https://www.notino.fr/medicube/one-day-exosome-shot-2000-serum-regeneration-intense-pour-une-peau-lumineuse-et-lisse/p-16313459/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin (this page)
- Italy: https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin