# Manyo Factory Bifida Biome Complex Ampoule for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Manyo Factory](https://lovi.care/skincare/fr/brands/manyo-factory)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Offers moderate benefits for oily shine and combination skin, as Bifida Lysate Ferment and Niacinamide help regulate sebum and strengthen your skin barrier.
- Multiple hyaluronic acid derivatives and fermented ingredients provide excellent barrier resilience and hydration, enhancing overall skin comfort.
- The product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Copper Tripeptide-1, Sodium Hyaluronate, Acetyl Hexapeptide-8

## What the research says

- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- Copper applied transdermally as a tripeptide on human skin ex vivo permeated the tissue and was retained in amounts potentially effective for treating inflammatory diseases. ([Inflammation Research, 2010](https://pubmed.ncbi.nlm.nih.gov/20703511/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))

## What reviewers say

Based on a very large amount of data, users widely praise this ampoule for its ability to strengthen the skin barrier and provide deep hydration without feeling heavy. Many report achieving a healthy, radiant glow and appreciate its lightweight, fast-absorbing texture, with some finding it soothing for redness and irritation. A small number of users experienced breakouts, and some felt the watery consistency was not moisturizing enough on its own or that the results did not justify the price.

- Liked: Strengthens barrier (mostly mentioned)
- Liked: Hydration and glow (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Soothing and calming (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Price vs. value (rarely noted)
- Disliked: Too watery (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Manyo Factory Bifida Biome Complex Ampoule a great fit for combination skin?

This treatment is a great fit because ingredients like Bifida Lysate Ferment and Niacinamide help control oily shine and strengthen your skin barrier. Multiple hyaluronic acid derivatives and fermented ingredients also deliver deep hydration and keep your skin feeling comfortable.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Which ingredients make this serum a good fit for combination skin?

Bifida Lysate Ferment and Niacinamide help control oily shine while strengthening your skin barrier. Multiple hyaluronic acid derivatives and fermented ingredients further provide deep hydration and enhance overall skin comfort without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Bifida Ferment Lysate do for combination skin?

Bifida Ferment Lysate helps strengthen the skin barrier and calm irritation, making it a good fit for combination skin that is prone to sensitivity. This ingredient works by supporting the skin defenses, keeping moisture locked in, and helping to reduce redness.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Putting it in the evening keeps things simple and avoids extra safety concerns around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the serum first to calm your skin and build up moisture, followed by your retinol. The soothing fermented ingredients and multiple forms of hyaluronic acid help keep your skin comfortable and reduce potential dryness from the retinol.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/)

### How often should I use this serum?

This serum fits your combination skin well and is best used in your evening routine, applying it once a day. Fermented ingredients like Bifida Lysate Ferment help strengthen your skin barrier while keeping oil and hydration balanced with a very low risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts on combination skin because it avoids harsh ingredients and includes soothing components. Its fermented ingredients and niacinamide help regulate oil and keep your skin balanced.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — €18.25 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/fr/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €35.99 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/fr/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €389.34 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice RESIST Perfectly Balanced Foaming Cleanser](https://lovi.care/skincare/fr/p/paula-s-choice/perfectly-balanced-foaming-cleanser/for/combination-skin) — Superior fit — €32.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/fr/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/fr/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €17.47 at Amazon

## Where to buy

- Amazon.fr: €29.58 (https://www.amazon.fr/dp/B08CK9HRV6?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
Prices checked 4 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Butylene Glycol, Bifida Ferment Filtrate, Lactobacillus Lysate Ferment, Lactococcus Lysate Ferment, Saccharomyces Ferment Filtrate, Glycerin, Niacinamide, 1,2-Hexanediol, Lactobacillus Pumpkin Fruit Ferment Filtrate, Aureobasidium Pullulans Ferment, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Leontopodium Alpinum Callus Culture Extract, Cutibacterium Granulosum Extract Ferment Filtrate, Asiaticoside, Asiatic Acid, Madecassic Acid, Pentylene Glycol, Squalane, Hydrogenated Lecithin, Copper Tripeptide-1, Tromethamine, Acetyl Hexapeptide-8, Propanediol, Ethylhexylglycerin, Dextrin, Water, Caffeine, Benzyl Glycol, Sodium Phytate, Hydrolyzed Algin, Xanthan Gum, Epigallocatechin Gallate, Carbomer, Physalis Alkekengi Calyx Extract, Hydrolyzed Glycosaminoglycans, Polyglyceryl-10 Laurate, Theobroma Cacao Seed Extract, Adenosine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin
- France: https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin (this page)
- Italy: https://lovi.care/skincare/it/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin