# ma:nyo Bifida Biome Complex Ampoule for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [ma:nyo](https://lovi.care/skincare/fr/brands/ma-nyo)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your dry and sensitive skin is provided by Bifida Lysate Ferment and multiple forms of hyaluronic acid, which deeply hydrate and support your skin barrier. Glycerin and squalane further enhance this effect by providing humectant and emollient properties, respectively, ensuring lasting moisture and comfort for your dry or flaky skin. The product is safe for your skin due to the absence of harsh ingredients and the inclusion of soothing components like Niacinamide.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Sodium Hyaluronate, Copper Tripeptide-1, Acetyl Hexapeptide-8

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))

## What reviewers say

Based on a very large amount of data, this ampoule is highly praised for repairing skin barriers and providing deep hydration for a glass skin effect without feeling heavy. It is a favorite for sensitive and dry skin types. A small number of users with fungal acne or sensitivity to ferments reported breakouts.

- Liked: Deep hydration (mostly mentioned)
- Liked: Strengthens skin barrier (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Estée Lauder dupe (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes ma:nyo Bifida Biome Complex Ampoule a great fit for dry sensitive skin?

This product is a great fit because Bifida Lysate Ferment and multiple types of hyaluronic acid deeply hydrate while soothing ingredients like Niacinamide keep your skin calm. Glycerin and squalane further help lock in lasting moisture and comfort for dry or flaky skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Bifida Lysate Ferment and multiple forms of hyaluronic acid make this serum a great fit by deeply hydrating and supporting your skin barrier. Glycerin and squalane further help by locking in lasting moisture and comfort for dry or flaky skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Bifida Ferment Lysate do for dry sensitive skin?

Bifida Ferment Lysate helps soothe dry sensitive skin by calming irritation and keeping moisture locked in. It strengthens your skin barrier so it stays soft and smooth against everyday stress. Using a product with this ingredient may also lower redness and keep your skin comfortable.
Sources: [Scientific Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37803101/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### What does Niacinamide do for dry sensitive skin?

Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [International Journal of Pharmaceutics, 2013](https://pubmed.ncbi.nlm.nih.gov/23220080/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This treatment serum goes in the evening routine after your toner and before your moisturizer. Putting it in the evening helps keep things simple and safe around sun exposure for dry and sensitive skin.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to calm and hydrate your skin before putting on your retinol. Using hydrating ingredients like glycerin and hyaluronic acid helps keep your skin comfortable and supports your skin barrier while you use retinoids.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

This treatment is meant to be used in the evening, applied after your toner and before your moisturizer. It is safe for daily use on your skin, helping to keep it deeply hydrated and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36798538/)

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores or cause breakouts for dry sensitive skin because it avoids harsh ingredients and features soothing components. Reviewers rarely report breakouts from it, and its hydrating ingredients help keep skin calm and smooth.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — €139.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin) — Superior fit — €57.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-sensitive-skin) — Superior fit — €18.25 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/fr/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €7.50 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/fr/p/skin1004/centella-asiatica-toning-toner/for/dry-sensitive-skin) — Superior fit — €18.79 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/fr/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — €29.95 at Amazon

## Where to buy

- Amazon.fr: €29.58 (https://www.amazon.fr/dp/B08CK9HRV6?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
Prices checked 4 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Butylene Glycol, Bifida Ferment Filtrate, Lactobacillus Lysate Ferment, Lactococcus Lysate Ferment, Saccharomyces Ferment Filtrate, Glycerin, Niacinamide, 1,2-Hexanediol, Lactobacillus Pumpkin Fruit Ferment Filtrate, Aureobasidium Pullulans Ferment, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Leontopodium Alpinum Callus Culture Extract, Cutibacterium Granulosum Extract Ferment Filtrate, Asiaticoside, Asiatic Acid, Madecassic Acid, Pentylene Glycol, Squalane, Hydrogenated Lecithin, Copper Tripeptide-1, Tromethamine, Acetyl Hexapeptide-8, Propanediol, Ethylhexylglycerin, Dextrin, Water, Caffeine, Benzyl Glycol, Sodium Phytate, Hydrolyzed Algin, Xanthan Gum, Epigallocatechin Gallate, Carbomer, Physalis Alkekengi Calyx Extract, Hydrolyzed Glycosaminoglycans, Polyglyceryl-10 Laurate, Theobroma Cacao Seed Extract, Adenosine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin (this page)
- Italy: https://lovi.care/skincare/it/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin