# La Roche-Posay Cicaplast B5 Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/fr/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [La Roche-Posay](https://lovi.care/skincare/fr/brands/la-roche-posay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Suitable for normal skin, this serum effectively moisturizes and enhances your skin barrier with panthenol and glycerin, which help to hydrate and support skin structure.
- While it offers general skincare benefits like hydration from sodium hyaluronate, it does not specifically target your primary concern of wrinkles and fine lines.
- The formulation is safe for your skin, containing no harsh ingredients that would cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/la-roche-posay/cicaplast-b5-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/la-roche-posay/cicaplast-b5-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/fr/p/la-roche-posay/cicaplast-b5-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/la-roche-posay/cicaplast-b5-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/la-roche-posay/cicaplast-b5-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/la-roche-posay/cicaplast-b5-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/la-roche-posay/cicaplast-b5-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/la-roche-posay/cicaplast-b5-serum/for/oily-acne-prone-skin): High

## Key ingredients

B5 Panthenol, Thermal Water, Sodium Hyaluronate, Glycerin, Dimethicone

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))
- Externally applied substances such as ceramides, hyaluronic acid, licorice extracts, dimethicone, petrolatum, and paraffin wax treat skin disease resulting from damage to the skin barrier. ([Clinics in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22507050/))

## What reviewers say

This serum is widely praised as a rescue product for compromised skin barriers, effectively soothing redness, dehydration, and irritation. Most users with dry or sensitive skin report rapid healing and improved texture. A minority experience stinging upon application or find the formula too tacky and the dropper packaging messy.

- Liked: Intense barrier repair (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Soothing for sensitive skin (often mentioned)
- Disliked: Poor packaging design (often mentioned)
- Liked: Improves skin texture (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Unpleasant texture/finish (sometimes noted)
- Disliked: Caused irritation/stinging (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes La Roche-Posay Cicaplast B5 Serum a great fit for mature skin?

La Roche-Posay Cicaplast B5 Serum is a great fit for mature skin because it deeply moisturizes and supports your skin barrier using panthenol and glycerin. While it does not specifically target wrinkles and fine lines, it has a safe formula with no harsh ingredients that might cause irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this serum a good fit for mature skin?

Panthenol and glycerin make this serum a good fit by hydrating your skin and supporting your skin barrier. Sodium hyaluronate adds extra moisture, though this formula does not specifically target wrinkles and fine lines.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Panthenol do for mature skin?

Panthenol helps mature skin by increasing moisture, improving skin elasticity, and reducing the look of wrinkles. It also supports skin barrier recovery and calms redness with a very safe profile.
Sources: [Lasers in Medical Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42686896/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Thermal Water do for mature skin?

Thermal water helps calm and soothe the skin while strengthening its natural barrier against daily environmental stress. It is unlikely to irritate mature skin and may help keep it comfortable and resilient.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2011](https://pubmed.ncbi.nlm.nih.gov/21175867/), [Journal of the European Academy of Dermatology and Venereology, 2022](https://pubmed.ncbi.nlm.nih.gov/34979589/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after your cleansing toner and before your moisturizer. Putting it in the evening keeps things simple and is safer around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying it before your retinol step to help keep your skin calm and hydrated. It is unlikely to cause irritation and may make your skin more comfortable while using stronger treatments.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### How often should I use this serum?

You can use this serum in the evening as part of your routine. Daily application helps keep your skin hydrated and supports the skin barrier.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or clog pores for mature skin because its formulation contains no harsh ingredients that would cause irritation. It relies on moisturizing ingredients like glycerin and panthenol that help hydrate the skin safely.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can I use this serum around the eyes or on my body?

You can use this serum around the eyes and on the body because its gentle formula is safe and unlikely to cause irritation. It helps hydrate and support the skin barrier with panthenol and glycerin.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for mature skin

- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/fr/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin) — High fit — €26.77 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/fr/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/mature-skin) — Average fit — €17.99 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/fr/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/mature-skin) — Average fit — €22.00 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/fr/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — €24.00 at Amazon

## Where to buy

- Lookfantastic: €38.64 (https://www.lookfantastic.fr/p/la-roche-posay-cicaplast-b5-face-serum-for-dehydrated-skin-30ml/14239221/)
- Notino: €40.50 (https://www.notino.fr/la-roche-posay/cicaplast-b5-serum-regenerant-a-usage-quotidien/p-16203220/)
Prices checked 10 Oct – 16 Oct 2026.

## Ingredients

Water, Panthenol, Glycerin, Alcohol Denat, Dimethicone, Hydroxyethylpiperazine Ethane Sulfonic Acid, Peg-20 Methyl Glucose Sesquistearate, Sodium Hyaluronate, Ammonium Polyacryloyldimethyl Taurate, Caprylyl Glycol, Vitreoscilla Ferment, Citric Acid, Xanthan Gum, Octyldodecanol, Tocopherol, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/la-roche-posay/cicaplast-b5-serum/for/mature-skin