# Isntree Hyaluronic Acid Moist Cream for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/fr/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Isntree](https://lovi.care/skincare/fr/brands/isntree)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for normal skin, as hyaluronic acid and glycerin provide humectant action, but the formula lacks sufficient emollients for optimal hydration. Palmitoyl pentapeptide-4 and adenosine offer some anti-aging benefits, supporting your goal of addressing wrinkles and fine lines.
- The product provides excellent moisturizing and barrier support with hyaluronic acid and panthenol, which are beneficial for general skin health.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of harsh ingredients and the presence of soothing components like hyaluronic acid and panthenol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/isntree/hyaluronic-acid-moist-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/isntree/hyaluronic-acid-moist-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/fr/p/isntree/hyaluronic-acid-moist-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/isntree/hyaluronic-acid-moist-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/isntree/hyaluronic-acid-moist-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/isntree/hyaluronic-acid-moist-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/isntree/hyaluronic-acid-moist-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/isntree/hyaluronic-acid-moist-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Hyaluronic Acid 10 Types, Glycerin, Butyrospermum Parkii Butter Shea Butter, Hyaluronic Acid, Panthenol

## What the research says

- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## Why other moisturizers fit mature skin better

- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Nanoemulsions containing Macadamia integrifolia seed oil successfully enhanced skin hydration and reduced wrinkles in human volunteers, outperforming conventional emulsions in skin hydration enhancement. ([Nanomaterials, 2024](https://pubmed.ncbi.nlm.nih.gov/38668218/))
- A night cream containing melatonin, carnosine, and Helichrysum italicum extract reduced oxidative stress ex vivo and improved hydration, reduced transepidermal water loss, decreased wrinkles and spots, and lowered skin reactivity in 117 individuals over up to 12 weeks of nightly use. ([Dermatology and Therapy, 2020](https://pubmed.ncbi.nlm.nih.gov/32915393/))

## What reviewers say

Based on a very large amount of data, this fragrance-free moisturizer is highly recommended for dry, normal, and combination skin types, providing significant hydration and a plumping effect. It is also frequently noted as gentle and soothing for sensitive skin. Some users with very dry skin find it insufficient for winter conditions, and a small number of users with oily skin report issues with heaviness or breakouts.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Gentle & non-irritating (often mentioned)
- Liked: Good value (sometimes noted)
- Liked: Pleasant texture (sometimes noted)
- Disliked: Lacks occlusivity (sometimes noted)
- Disliked: Absorption issues (rarely noted)
- Disliked: Plain experience (rarely noted)
- Disliked: Too rich for oily (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Isntree Hyaluronic Acid Moist Cream work for mature skin?

Isntree Hyaluronic Acid Moist Cream works reasonably well for mature skin, helping to hydrate and smooth fine lines with ingredients like hyaluronic acid and peptides. However, other options may fit better because this formula lacks enough softening ingredients to maintain optimal moisture balance for mature skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/)

### Which ingredients make this cream a good fit for mature skin?

This cream fits mature skin because it contains hyaluronic acid and glycerin to draw in moisture, along with palmitoyl pentapeptide-4 and adenosine to help smooth out wrinkles and fine lines. Panthenol and shea butter are also included to support overall skin health and softness. To work even better for mature skin, a product of this type needs a richer blend of emollients alongside its humectants to maintain ideal moisture balance.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by significantly improving skin hydration, elasticity, and reducing the depth of wrinkles. Regular use of these formulations makes dry skin feel much softer and smoother while helping to diminish the appearance of fine lines over time.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this cream go in a skincare routine for mature skin?

This moisturizer goes after your hydrating toner in the morning and after your treatment in the evening. It helps keep your skin soft and hydrated, though mature skin often needs richer oils and butters for optimal moisture.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the retinol first and following it with the moisturizer to help soothe the skin and reduce irritation. Mature skin needs a moisturizer packed with rich smoothing butters, plant oils, and ceramides to lock in moisture and deeply soften fine lines.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this cream twice a day in your morning and evening routines. Daily application helps keep your skin soft and smooth while supporting your skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, as it has a very safe formula free of harsh ingredients and includes soothing components. However, a product for this skin needs richer softeners and sealing ingredients to deeply hydrate and smooth out lines.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this cream around the eyes or on my body?

You can use this cream around your eyes and on your body, as its safe formula is unlikely to irritate thin skin. Because mature skin needs richer hydration and barrier support in those areas, this product works best alongside a richer moisturizer with extra softening ingredients.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — €20.46 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/fr/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €95.00 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/fr/p/cosrx/advanced-snail-96-mucin-power-essence/for/mature-skin) — Superior fit — €14.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/fr/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — €24.00 at Amazon

## Where to buy

- Amazon.fr: €18.99 (https://www.amazon.fr/dp/B08DN1W613?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Notino: €23.50 (https://www.notino.fr/isntree/hyaluronic-acid-creme-de-jour-hydratante-intense/p-16116735/)
- Lookfantastic: €23.98 (https://www.lookfantastic.fr/p/isntree-hyaluronic-acid-moist-cream-100ml/15443548/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Glycerin, Hyaluronic Acid, Caprylic Capric Triglyceride, Cetearyl Alcohol, Betaine, Panthenol, Allantoin, 1,2-Hexanediol, Ethylhexylglycerin, Adenosine, Disodium Edta, Dimethicone, Hydrolyzed Hyaluronic Acid, Ceramide Np, Butyrospermum Parkii Butter, Theobroma Cacao Seed Butter, Hydroxypropyltrimonium Hyaluronate, Sodium Acetylated Hyaluronate, Palmitoyl Pentapeptide-4, Cholesterol, Tromethamine, Ascorbyl Propyl Hyaluronate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/isntree/hyaluronic-acid-moist-cream/for/mature-skin