# iS Clinical Super Serum Advance+ for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [iS Clinical](https://lovi.care/skincare/fr/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Offers excellent treatment for brightening and evening skin tone, as ascorbic acid and arbutin provide antioxidant and skin-brightening effects beneficial for your normal skin.
- The presence of Ascorbic Acid and Tripeptide-1 effectively addresses your wrinkles and fine lines by promoting collagen synthesis and offering antioxidant protection.
- This formula is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin): High

## Key ingredients

Ascorbic Acid, Sodium Hyaluronate, Arbutin, Tripeptide-1, Madecassic Acid

## What the research says

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- Polyvinyl pyrrolidone-K90/Eudragit RL100 dissolving microneedle patches loaded with alpha-arbutin and resveratrol enhanced intradermal delivery by approximately 2.6 times compared to cream and slightly decreased the melanin index in human participants without causing skin irritation. ([Biomaterials Science, 2023](https://pubmed.ncbi.nlm.nih.gov/37183632/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))

## What reviewers say

This serum is highly regarded for its ability to brighten skin and reduce the appearance of scars and stretch marks. It is often described as a lightweight, fast-absorbing treatment suitable for acne-prone and aging skin, although its high price is a frequent concern among users.

- Liked: Brightens skin tone (mostly mentioned)
- Liked: Anti-aging effects (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Reduces scars/marks (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Non-irritating (sometimes noted)
- Disliked: Watery consistency (sometimes noted)
- Disliked: Application sensation (rarely noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Packaging/Value (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Super Serum Advance+ a great fit for mature skin?

This serum is a great fit because ascorbic acid and tripeptide-1 help smooth out fine lines and wrinkles by supporting collagen, while arbutin and ascorbic acid brighten your skin and even out its tone. It is also very safe for your skin, as it does not contain harsh ingredients that might cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/)

### Which ingredients make this serum a good fit for mature skin?

Ascorbic acid and arbutin make this serum a great fit by brightening your skin and evening out your skin tone. Additionally, ascorbic acid and tripeptide-1 help smooth out wrinkles and fine lines by supporting collagen production.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/)

### What does Vitamin C do for mature skin?

Vitamin C helps mature skin by smoothing out wrinkles, brightening dark spots, and boosting firmness. It works by encouraging collagen production to keep skin looking youthful and radiant.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Using an antioxidant vitamin C serum helps improve skin brightness and target fine lines over time.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this vitamin C treatment in your morning routine and your retinol at night. Using them at different times of day helps prevent irritation while supporting your skin against fine lines and uneven tone.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### How often should I use this serum?

You can use this serum in your evening routine, as treatments fit best there for simplicity and safety around sun exposure. If your mature skin tolerates it well and you see good results, you may carefully use it more often.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores, cause breakouts, or lead to purging on mature skin. Its formula is safe and free of harsh ingredients that typically trigger irritation or congestion.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €139.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/fr/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — €599.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/fr/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €76.29 at Amazon

## Where to buy

- Amazon.fr: €208.00 (https://www.amazon.fr/dp/B0027583BO?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Ascorbic Acid, Sodium Hyaluronate, Pentylene Glycol, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Calcium Pantothenate, Zinc Sulfate, Urea, Glucose, Guanidine Hcl, Tripeptide-1, Glycerin, Phenoxyethanol, Asiaticoside, Asiatic Acid, Madecassic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/super-serum-advance/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/super-serum-advance/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/super-serum-advance/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/super-serum-advance/for/mature-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/is-clinical/super-serum-advance/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/super-serum-advance/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/super-serum-advance/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/super-serum-advance/for/mature-skin