# iS Clinical Active Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [iS Clinical](https://lovi.care/skincare/fr/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate exfoliation for acne-prone skin due to Saccharum Officinarum Extract and Willow Bark Extract, which help reduce blemishes, but these ingredients do not directly address your primary concern of wrinkles and fine lines.
- While Glycerin and Butylene Glycol provide hydration suitable for normal skin, the formula lacks sufficient emollient ingredients for optimal results in managing your skin type.
- The product is generally safe for your normal skin, though Alcohol Denat and Menthol may pose a slight risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/oily-acne-prone-skin): High

## Key ingredients

Saccharum Officinarum Extract, Vaccinium Myrtillus Extract, Arbutin, Willow Bark Extract, Polyporus Umbellatus Extract Mushroom Extract

## What the research says

- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical 30% l-menthol decreased cold pain thresholds and enhanced pain responses to suprathreshold noxious cold stimuli without affecting other stimuli in 39 healthy subjects compared to ethanol control. ([Pain, 2006](https://pubmed.ncbi.nlm.nih.gov/16527405/))
- Cooling skin temperature or applying topical menthol reduced histamine-induced itch intensity and flare diameters in healthy male volunteers. ([Neuroscience Letters, 1995](https://pubmed.ncbi.nlm.nih.gov/7624016/))
- Coadministration of 40% topical L-menthol with 10% trans-cinnamaldehyde reduced spontaneous pain intensity, neurogenic inflammation, primary and secondary mechanical hyperalgesia, and heat hyperalgesia, but not cold hyperalgesia, in 14 healthy volunteers. ([The Journal of Pain, 2016](https://pubmed.ncbi.nlm.nih.gov/27260636/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- A novel emulsion containing niacinamide, lens esculenta seed extract, and white willow bark extract effectively improved acne, blackheads, and conspicuous facial pores in 30 subjects with oily skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38140770/))
- White button mushroom extract treatment increased VEGF densities, EGF, PCNA, and collagen fibers, while decreasing apoptotic cells and limiting TGF-beta and CD4 reactions in ICR mice and chorioallantoic culture, indicating beneficial effects on skin regeneration and injury. ([Microscopy Research and Technique, 2012](https://pubmed.ncbi.nlm.nih.gov/22581761/))

## Why other serums fit mature skin better

- Topical menthol induced significant pain, cold sensations, punctate and cold hyperalgesia, and increased cutaneous perfusion in 10 subjects compared to ethanol control, acting as a human model for cold pain by sensitizing peripheral cold C nociceptors and activating cold-specific A delta fibres. ([Brain, 2004](https://pubmed.ncbi.nlm.nih.gov/14985268/))
- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))

## What reviewers say

Users consistently praise this serum as a "holy grail" multitasker that effectively targets adult acne while simultaneously smoothing fine lines and uneven texture. While the potent "tingling" sensation confirms its activity for most, the high price point and potential for dryness are common considerations for new users.

- Liked: Clears Acne & Breakouts (mostly mentioned)
- Liked: Improves Texture & Tone (often mentioned)
- Disliked: High Price Point (often mentioned)
- Liked: Anti-Aging Benefits (sometimes noted)
- Liked: Fast Visible Results (sometimes noted)
- Disliked: Intense Tingling Sensation (sometimes noted)
- Disliked: Drying for Some (rarely noted)
- Disliked: Risk of Counterfeits (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does iS Clinical Active Serum work for mature skin?

iS Clinical Active Serum works moderately well for mature skin because it offers some exfoliation, but it does not directly target wrinkles and fine lines. While it includes hydrating ingredients like glycerin, it lacks the nourishing, softening components needed for optimal anti-aging results. A treatment of this type needs high-quality ingredients that effectively target wrinkles, improve firmness, and keep the skin feeling soft without any risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

This serum is an average fit for mature skin because it lacks sufficient smoothing and softening ingredients to best care for fine lines and wrinkles. A treatment of this type needs high-quality anti-aging ingredients, rich moisturizing components to keep skin soft, and a gentle formula without potential irritants like alcohol and menthol.
Sources: [Pain, 2006](https://pubmed.ncbi.nlm.nih.gov/16527405/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Sugarcane Extract do for mature skin?

Sugarcane Extract helps smooth and soften mature skin by gently removing dead skin cells to reveal a fresher look. It is unlikely to cause irritation when used properly, and it helps improve the feel of dry or rough areas.

### What does Bilberry Fruit Extract do for mature skin?

Bilberry fruit extract helps improve wrinkle depth, firmness, and elasticity while making mature skin smoother and more even-toned. It may also provide antioxidant support to help protect against everyday environmental stress.
Sources: [Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/)

### Where does it go in a skincare routine for mature skin?

This treatment goes in the evening routine. Mature skin of this type needs rich softening ingredients and targeted anti-aging actives to effectively smooth fine lines and wrinkles.

### Can I use this serum with retinol, and in what order?

You can use this serum in your evening routine, but apply it on a different night than your retinol to help lower the risk of skin irritation from its alcohol and menthol. To properly care for mature skin, a product of this type needs richer, softening ingredients that smooth fine lines and wrinkles.

### How often should I use it?

Start using this treatment once a week in your evening routine, and if your skin feels comfortable, you may carefully use it more often. Alcohol and menthol in the formula may pose a slight risk of irritation.

### Can it clog pores, cause breakouts or purging for mature skin?

This treatment is unlikely to clog pores or cause breakouts on mature skin, as it contains Willow Bark Extract and Saccharum Officinarum Extract, which help clear blemishes. However, because it lacks sufficient rich softening ingredients, a product of this type for mature skin needs extra nourishing moisturizers and ingredients that target wrinkles.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €139.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/fr/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — €599.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/fr/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €76.29 at Amazon

## Where to buy

- Amazon.fr: €267.50 (https://www.amazon.fr/dp/B007PFIOUQ?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Alcohol Denat, Saccharum Officinarum Extract, Vaccinium Myrtillus Leaf Extract Fruit, Triethanolamine, Willow Bark Extract, Glyceryl Polyacrylate, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Menthol, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/active-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/active-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/active-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/is-clinical/active-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/active-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/active-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/active-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/active-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/mature-skin