# Eucerin Hyaluron-Filler Epigenetic Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/fr/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Eucerin](https://lovi.care/skincare/fr/brands/eucerin)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing for your normal skin due to the humectant action of glycerin and hyaluronic acid, but these ingredients do not directly address your primary concern of wrinkles and fine lines.
- While the formula is safe for normal skin and provides general hydration, it lacks ingredients specifically targeted to reduce the appearance of wrinkles and fine lines.
- The product is safe for your normal skin as it contains no harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/eucerin/hyaluron-filler-epigenetic-serum/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/fr/p/eucerin/hyaluron-filler-epigenetic-serum/for/dry-skin): Warning
- [Combination skin](https://lovi.care/skincare/fr/p/eucerin/hyaluron-filler-epigenetic-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/eucerin/hyaluron-filler-epigenetic-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/eucerin/hyaluron-filler-epigenetic-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/eucerin/hyaluron-filler-epigenetic-serum/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/fr/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/eucerin/hyaluron-filler-epigenetic-serum/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/eucerin/hyaluron-filler-epigenetic-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Glycerin, Hyaluronic Acid

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## Why other moisturizers fit mature skin better

- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))

## What reviewers say

Based on a very large amount of data, users consistently report that the serum provides an immediate boost of hydration, leaving skin feeling significantly smoother, softer, and more radiant. While many observed a reduction in fine lines and a "plumped" effect within a few weeks, a small minority experienced skin irritation or felt the anti-aging results were not visible enough to justify the price.

- Liked: Lightweight, fast absorption (mostly mentioned)
- Liked: Layers well (often mentioned)
- Liked: Smoother, plumper skin (often mentioned)
- Liked: Pleasant, subtle scent (sometimes noted)
- Liked: Radiant, fresh glow (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Allergic reactions (rarely noted)
- Disliked: No visible results (rarely noted)
- Disliked: Scent too strong (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Eucerin Hyaluron-Filler Epigenetic Serum work for mature skin?

This serum works well to keep mature skin hydrated, but it does not directly target wrinkles and fine lines. To truly help mature skin, a product of this type needs effective anti-wrinkle ingredients that smooth the skin without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

Glycerin and hyaluronic acid make this serum a good fit for mature skin by drawing in moisture to keep your skin hydrated and smooth. However, to truly care for mature skin, a product of this type needs effective anti-wrinkle ingredients that smooth lines and support your skin's youthful firmness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Water do for mature skin?

Water helps keep mature skin hydrated, which significantly lowers the severity of wrinkles and maintains elasticity. Because aging skin often loses moisture and firmness, it needs hydrating ingredients like glycerin and hyaluronic acid to stay plump and smooth.
Sources: [Skin Research and Technology, 2013](https://pubmed.ncbi.nlm.nih.gov/22672420/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, following Lovi routines that put treatments in the evening for simplicity and extra safety around sun exposure. This product works for mature skin by providing moderate moisture through glycerin and hyaluronic acid, though a product of this type needs dedicated anti-aging ingredients like peptides or retinol to directly target fine lines and wrinkles.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your skin a boost of hydration, followed by your retinol. This routine helps keep your skin comfortable while you use active ingredients. To better care for mature skin, a product of this type needs added ingredients that target wrinkles and fine lines.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. Daily application helps keep your skin hydrated and supports a smooth barrier.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin because its gentle formula lacks heavy oils or harsh ingredients. It helps keep your skin feeling soft and comfortable while maintaining a safe profile for daily use.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this serum around the eyes or on my body?

You can use this serum safely around the eyes and on the body because its gentle formula contains no harsh ingredients and provides general hydration. However, a product for mature skin needs targeted ingredients like specific plant extracts or active peptides to effectively address wrinkles and fine lines.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol denat).

## Alternatives for mature skin

- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/fr/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin) — High fit — €26.77 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/fr/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/mature-skin) — Average fit — €17.99 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/fr/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/mature-skin) — Average fit — €22.00 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/fr/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — €24.00 at Amazon

## Where to buy

- Amazon.fr: €39.38 (https://www.amazon.fr/dp/B0DFMNQ9R9?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Notino: €50.00 (https://www.notino.fr/eucerin/hyaluron-filler-serum-rajeunissant-intense-anti-age/p-16273377/)
Prices checked 14 Oct – 4 Nov 2026.

## Ingredients

Water, Glycerin, Alcohol Denat, Hyaluronic Acid, Epicelline, Panthenol, Glyceryl Glucoside, Sodium Hydroxide, Phenoxyethanol, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/eucerin/hyaluron-filler-epigenetic-serum/for/mature-skin