# Drunk Elephant Protini Polypeptide Cream for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Drunk Elephant](https://lovi.care/skincare/fr/brands/drunk-elephant)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- This product offers excellent moisturizing and anti-aging benefits for your oily skin, as multiple peptides like Sh-Oligopeptide-1 and Sh-Oligopeptide-2 work synergistically with sodium hyaluronate to hydrate and smooth texture.
- The inclusion of Nymphaea Alba Root Extract and amino acids further supports your skin barrier function and regeneration, providing beneficial effects for acne, blemishes, and breakouts.
- The formula is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin): Superior
- [Sensitive skin](https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin): High (this page)

## Key ingredients

9 Signal Peptides, Pygmy Waterlily, Sodium Hyaluronate, Glycerin, Copper Palmitoyl Heptapeptide-14

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Water lily rhizome extract protected human epidermal keratinocytes against UVB-induced mitochondria-mediated apoptosis by reducing reactive oxygen species generation, mitochondrial dysfunction, and apoptotic signaling while increasing antiapoptotic proteins and antioxidant levels. ([Pharmacology, 2016](https://pubmed.ncbi.nlm.nih.gov/26915077/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this moisturizer is frequently praised for its lightweight, non-greasy texture that firms and plumps the skin, making it a favorite for combination and oily skin types. It also performs well under makeup and is generally well-tolerated by sensitive skin. However, some users with very dry skin find it lacks sufficient hydration, and a significant number of reviews mention the high price point as a drawback.

- Liked: Lightweight texture (mostly mentioned)
- Disliked: High price (mostly mentioned)
- Liked: Hygienic packaging (often mentioned)
- Liked: Makeup compatibility (sometimes noted)
- Liked: Sensitive skin friendly (sometimes noted)
- Liked: Visible results (sometimes noted)
- Disliked: Dry skin hydration (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Drunk Elephant Protini Polypeptide Cream a great fit for oily acne-prone skin?

This cream is a great fit because its peptides and sodium hyaluronate hydrate and smooth your oily skin while supporting your skin barrier against breakouts. The formula is safe and unlikely to cause irritation.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for oily acne-prone skin?

This cream is a great fit for your oily acne-prone skin because multiple peptides like Sh-Oligopeptide-1 and Sh-Oligopeptide-2 work alongside sodium hyaluronate and glycerin to hydrate your skin and smooth its texture. Nymphaea Alba Root Extract and amino acids further support your skin barrier and regeneration to help with breakouts, with no risk of irritation.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Signal Peptides do for oily acne-prone skin?

Signal peptides help calm oily, acne-prone skin by reducing inflammation and supporting skin barrier recovery. This type of ingredient is unlikely to clog pores and may improve blemishes when included in your daily routine.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/)

### What does Pygmy Waterlily do for oily acne-prone skin?

Pygmy Waterlily helps calm oily, acne-prone skin and reduces shine. This type of skin needs lightweight hydrators and ingredients that balance oil production to keep pores clear and smooth.

### Where does this cream go in a skincare routine for oily acne-prone skin?

This moisturizing treatment goes after your toner and before your sunscreen in the morning, and as the final step in the evening. It is a great fit for your oily, acne-prone skin because multiple peptides and sodium hyaluronate hydrate and smooth texture without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

Yes, you can use this moisturizing treatment with retinol by applying the moisturizer after your retinol treatment in the evening routine. This safe formula helps hydrate your skin and supports your skin barrier, which is unlikely to cause irritation when combined with active treatments.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/), [The Journal of Dermatological Treatment, 2016](https://pubmed.ncbi.nlm.nih.gov/26293170/)

### How often should I use this cream?

You can use this cream twice a day as part of your morning and evening routine to keep your skin hydrated and smooth. Regular daily application helps improve moisture levels and supports your skin barrier without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for oily acne-prone skin?

This cream is unlikely to clog pores or cause breakouts for oily acne-prone skin, as it has a very low complaint rate for causing breakouts and contains soothing components with no harsh ingredients.

### Can I use this cream around the eyes or on my body?

This moisturizing treatment is well suited for the thin skin around the eyes and body because its lightweight peptides and hydrating ingredients nourish delicate areas without causing irritation. Regular application helps smooth texture and maintain moisture while supporting skin barrier function across different body regions.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for oily acne-prone skin

- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/fr/p/cosrx/advanced-snail-96-mucin-power-essence/for/oily-acne-prone-skin) — Superior fit — €14.90 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/fr/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/oily-acne-prone-skin) — Superior fit — €17.90 at Amazon
- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/fr/p/belif/the-true-cream-aqua-bomb/for/oily-acne-prone-skin) — High fit — €34.16 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/fr/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — €11.35 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/fr/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/fr/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-acne-prone-skin) — Superior fit — €34.30 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Water, Dicaprylyl Carbonate, Glycerin, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Sclerocarya Birrea Seed Oil, Bacillus Folic Acid Extract Ferment, Nymphaea Alba Root Extract, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate Caprate, Sodium Hyaluronate, Aspartic Acid, Linoleic Acid, Linolenic Acid, Lecithin, Butylene Glycol, Polyvinyl Alcohol, Sodium Lactate, Sodium Pca, Pca, Sorbitan Isostearate, Carbomer, Polysorbate 20, Polysorbate 60, Lactic Acid Glycolic Acid Copolymer, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Isomalt, 1,2-Hexanediol, Caprylyl Glycol, Chlorphenesin, Phenoxyethanol, Tocopherol, Sodium Benzoate, Phenylpropanol, Glyceryl Caprylate, Symphytum Officinale Callus Culture Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin (this page)
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