# Derma E Anti-Wrinkle Renewal Cream for dry sensitive skin

**Lovi Fit: Average fit for dry sensitive skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Derma E](https://lovi.care/skincare/fr/brands/derma-e)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry sensitive skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing and anti-aging benefits for your dry and sensitive skin, as glycerin and avocado oil provide emollient action, while retinol helps smooth texture.
- The inclusion of Carthamus Tinctorius Seed Oil and Panthenol Vitamin B5 further supports hydration and soothing, though more potent humectants could enhance results for flaky skin.
- The product is generally safe for your skin, with a low risk of irritation from retinol in moderate concentrations.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin): Average (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Bakuchiol, Panthenol Vitamin B5, Tocopheryl Acetate Vitamin E, Carthamus Tinctorius Seed Oil

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels. ([The Journal of Investigative Dermatology, 1995](https://pubmed.ncbi.nlm.nih.gov/7561157/))
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/))
- Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days. ([Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/))
- Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24471735/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- Safflower oil body-human epidermal growth factor microgel emulsions mixed with xanthan gum enhance transdermal absorption, regulate inflammation, accelerate angiogenesis, and promote re-epithelialization and remodeling in full-layer skin wounds in rats. ([International Journal of Biological Macromolecules, 2022](https://pubmed.ncbi.nlm.nih.gov/36126813/))

## Why other moisturizers fit dry sensitive skin better

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Nanoemulsions containing Macadamia integrifolia seed oil successfully enhanced skin hydration and reduced wrinkles in human volunteers, outperforming conventional emulsions in skin hydration enhancement. ([Nanomaterials, 2024](https://pubmed.ncbi.nlm.nih.gov/38668218/))

## How to apply

- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Derma-E Anti-Wrinkle Renewal Cream work for dry sensitive skin?

This cream works moderately well for dry sensitive skin by offering basic hydration and smoothing texture, though a product of this type needs stronger moisture-holding ingredients and soothing agents to truly stop flaking and fully support this skin type.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Which ingredients make this cream a good fit for dry sensitive skin?

Glycerin and avocado oil provide gentle moisture, while retinol helps smooth texture for dry and sensitive skin. Carthamus tinctorius seed oil and panthenol vitamin B5 further support hydration and calm the skin. A product of this type needs more potent moisture-locking ingredients and soothing agents to best address flaky, sensitive skin.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### What does Retinol do for dry sensitive skin?

Retinol is often too strong for dry sensitive skin because it may cause scaling and stinging, so a product of this type needs gentle soothing ingredients and extra moisture to keep the skin calm and smooth.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Toxicology Letters, 2003](https://pubmed.ncbi.nlm.nih.gov/14615068/)

### What does Bakuchiol do for dry sensitive skin?

Bakuchiol is a gentle, plant-based option that helps smooth lines, improve firmness, and even out skin tone without causing the dryness, redness, or stinging often linked to traditional retinol. It is generally well-tolerated by delicate skin types and helps improve overall moisture and softness with regular use.
Sources: [Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/), [Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33346506/)

### Where does it go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine after cleansing and toning, followed by a moisturizer. This helps keep it simple and adds safety around sun exposure. A product of this type for dry sensitive skin needs stronger hydrating ingredients to better soothe flaky areas.

### Can I use this cream with vitamin C, and in what order?

You can use this cream with vitamin C by applying vitamin C first in your morning routine and this treatment at night, as using them separately helps prevent irritation on dry sensitive skin. A product of this type needs stronger water-binding ingredients and rich soothing oils to keep flaky skin fully hydrated and calm.

### How often should I use it?

This cream works best as an evening treatment for your dry sensitive skin. Using it in your nighttime routine helps smooth texture while keeping your skin calm and safe from sun exposure.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for dry sensitive skin?

This cream is unlikely to clog pores, but the retinol in it may cause mild peeling or purging when you first start using it. It is generally safe for your skin, though dry and sensitive skin often needs stronger moisture-locking ingredients and soothing agents to prevent flaking.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Can I use it around the eyes or on my body?

You can use this moisturizing treatment on your body and around the eyes, though the skin on the body and eyelids is very different in thickness. It offers moderate anti-aging and moisturizing benefits, but a product for this skin needs stronger moisture-attracting ingredients to better help flaky areas.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry sensitive skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-sensitive-skin) — Superior fit — €20.46 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/fr/p/the-ordinary/natural-moisturizing-factors-ha/for/dry-sensitive-skin) — Superior fit — €13.11 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/fr/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/dry-sensitive-skin) — Superior fit — €17.90 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/fr/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €7.50 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/fr/p/skin1004/centella-asiatica-toning-toner/for/dry-sensitive-skin) — Superior fit — €18.79 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/fr/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — €29.95 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Water, Carthamus Tinctorius Seed Oil, Stearic Acid, Glycerin, Glyceryl Stearate Se, Cetyl Alcohol, Microcrystalline Cellulose, Cellulose Gum, Persea Gratissima Oil Avocado Oil, Sesamum Indicum Seed Oil, Helianthus Annuus Seed Oil Sunflower Seed Oil, Bakuchiol, Retinol, Panthenol Vitamin B5, Tocopheryl Acetate Vitamin E, Allantoin, Phenoxyethanol, Ethylhexylglycerin, Oils
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin (this page)
- Italy: https://lovi.care/skincare/it/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/derma-e/anti-wrinkle-renewal-cream/for/dry-sensitive-skin