# Clinique Dramatically Different Moisturizing Lotion+ for acne-prone skin

**Lovi Fit: Low fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: High · Safety: Concerning.

Page: https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Clinique](https://lovi.care/skincare/fr/brands/clinique)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for acne-prone skin; the moisturizers alongside fit it better.

## Why this fit

- Offers excellent moisturizing for your combination skin due to glycerin and sodium hyaluronate, which hydrate and plump effectively, but the inclusion of mineral oil and petrolatum may pose a risk of worsening acne and blemishes for you.
- While generally safe for your combination skin, the formula lacks sufficient targeted ingredients to fully address your primary concerns with acne and breakouts.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/oily-skin): Caution
- [Dry skin](https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/combination-skin): Caution
- [Sensitive skin](https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin): Low (this page)
- [Skin with dark spots](https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/oily-acne-prone-skin): Caution

## Key ingredients

Glycerin, Sodium Hyaluronate, Sesamum Indicum Oil, Cucumis Sativus Fruit Extract, Hordeum Vulgare Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of sesame oil combined with standard care significantly reduced infusion-related phlebitis in adults compared to a control condition, with a risk ratio of 0.54. ([Complementary Therapies in Medicine, 2025](https://pubmed.ncbi.nlm.nih.gov/39743002/))
- Sesamol loaded silver nanoparticles gel showed a twofold increase in skin permeation and higher antioxidant activity compared to conventional formulations, demonstrating potential for topical wound healing delivery. ([Current Pharmaceutical Design, 2024](https://pubmed.ncbi.nlm.nih.gov/39192646/))
- Treatment with moderately ozonated sesame oil accelerates cutaneous wound closure and enhances cell response, angiogenesis, and VEGF and cyclin D1 expression in SKH1 mice compared to oil with lower or higher peroxide values and controls. ([Wound Repair and Regeneration, 2011](https://pubmed.ncbi.nlm.nih.gov/21134039/))
- Transgenic cucumber expressing poly-γ-glutamic acid synthesis genes increased water content by 6-14%, reduced water loss by 11-12%, decreased facial wrinkles and roughness by 19.58% and 24.97%, decreased skin melanin by 5.27%, and improved facial elasticity in human skin and zebrafish compared to controls. ([International Journal of Biological Macromolecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38336313/))
- Copper Oxide nanoparticles synthesized using cucumber extract exhibited antibacterial, antifungal, UV protection, and reactive-oxygen species inhibition properties with low cellular toxicity and skin-rejuvenating effects when incorporated into skin cream. ([Endocrine, Metabolic & Immune Disorders Drug Targets, 2021](https://pubmed.ncbi.nlm.nih.gov/32628604/))
- Topical treatment with Holothuria parva extract gel showed significant wound contraction compared to the negative control in full-thickness wounded rats. ([The International Journal of Lower Extremity Wounds, 2024](https://pubmed.ncbi.nlm.nih.gov/34791922/))

## Why other moisturizers fit acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35763437/))

## What reviewers say

Based on a very large amount of data, this lotion is a highly regarded staple for dry and combination skin, frequently praised for restoring the moisture barrier and leaving a soft, non-greasy finish. Most users report improved hydration and a healthy glow. A moderate number of users experienced breakouts or found the texture too heavy for oily areas.

- Liked: Effective hydration (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Gentle/fragrance-free (sometimes noted)
- Liked: Makeup compatibility (sometimes noted)
- Disliked: Caused breakouts (sometimes noted)
- Disliked: Formula change (rarely noted)
- Disliked: Greasy residue (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### Why is Clinique Dramatically Different Moisturizing Lotion+ a weak match for acne-prone skin?

This moisturizer is a weak match because mineral oil and petrolatum may worsen acne and breakouts, while the formula lacks targeted ingredients to address these concerns. A product of this type for acne-prone skin needs effective ingredients that manage blemishes, hydrate and repair without irritation, and include soothing extracts or peptides.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this moisturizer a poor fit for acne-prone skin?

Mineral oil and petrolatum in this moisturizer may worsen acne and breakouts by clogging pores. Acne-prone skin needs a product that includes targeted soothing extracts, peptides, and hydrating ingredients without any risk of clogging pores or causing irritation.

### What does Glycerin do for acne-prone skin?

Glycerin helps keep acne-prone skin hydrated and calm without clogging pores or feeling heavy. It supports the skin barrier so it stays soft and smooth while handling everyday treatments.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [International Journal of Toxicology, 2019](https://pubmed.ncbi.nlm.nih.gov/31840548/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does it go in a skincare routine for acne-prone skin?

This moisturizer goes after your hydrating toner in the morning, and after your treatment step at night. Because mineral oil and petrolatum may worsen breakouts on acne-prone skin, a moisturizer for this skin type needs lightweight hydrating ingredients like glycerin and sodium hyaluronate alongside blemish-clearing ingredients that keep pores clear.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

You can use this moisturizer with retinol, applying it after your retinol treatment to help buffer potential irritation. However, because this formula contains heavy ingredients like mineral oil and petrolatum, it may clog pores and worsen blemishes for acne-prone skin. To better support acne-prone skin, a moisturizer of this type needs lightweight hydrators and soothing, breakout-clearing ingredients without pore-clogging heavy oils.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use it?

You can use this moisturizer twice a day, in the morning and evening, as part of your daily skincare routine. Regular use helps keep your skin hydrated, but because it contains heavy oils that may worsen breakouts, this skin type needs a lightweight, oil-free moisturizer with acne-fighting ingredients like salicylic acid or niacinamide instead.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Skin Pharmacology and Physiology, 2026](https://pubmed.ncbi.nlm.nih.gov/41231732/)

### Can this moisturizer clog pores, cause breakouts or purging for acne-prone skin?

This moisturizer is a weak match for your acne-prone skin because the heavy oils and petrolatum inside may clog pores and worsen breakouts. A product of this type needs lightweight hydrators and ingredients that clear pores without heavy oils to properly care for acne-prone skin.

### Can I use it around the eyes or on my body?

This moisturizer is generally safe for the body, but acne-prone skin needs a lightweight, oil-free formula with ingredients like salicylic acid or niacinamide rather than heavy oils to prevent clogged pores.

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/fr/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €17.90 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/fr/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — €14.90 at Amazon
- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/fr/p/belif/the-true-cream-aqua-bomb/for/acne-prone-skin) — High fit — €34.16 at Amazon

## Routine for acne-prone skin

### AM

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/fr/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.98 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/fr/p/la-mer/the-tonic/for/acne-prone-skin) — Superior fit — €10.25 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/fr/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €17.90 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/fr/p/d-alba/piedmont-waterfull-mild-sunscreen/for/acne-prone-skin) — Superior fit — €16.99 at Amazon

### PM

- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/fr/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/acne-prone-skin) — Superior fit — €40.00 at Amazon
- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/fr/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.98 at Amazon
- Cleansing Toner: [Medicube Zero Pore Pad 2.0](https://lovi.care/skincare/fr/p/medicube/zero-pore-pad-2-0/for/acne-prone-skin) — Superior fit — €17.15 at Amazon
- Serum or Treatment: [The Ordinary Niacinamide 10% + Zinc 1%](https://lovi.care/skincare/fr/p/the-ordinary/niacinamide-10-zinc-1/for/acne-prone-skin) — Superior fit — €5.75 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/fr/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €17.90 at Amazon

### Weekly

- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/fr/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/acne-prone-skin) — Superior fit — €40.00 at Amazon
- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/fr/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.98 at Amazon
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/fr/p/dermalogica/daily-microfoliant/for/acne-prone-skin) — Superior fit — €49.00 at Amazon
- Cleansing Mask: [Herbivore Botanicals Blue Tansy Resurfacing Clarity Mask](https://lovi.care/skincare/fr/p/herbivore-botanicals/blue-tansy-bha-and-enzyme-pore-refining-mask/for/acne-prone-skin) — Superior fit — €79.97 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/fr/p/la-mer/the-tonic/for/acne-prone-skin) — Superior fit — €10.25 at Amazon
- Serum or Treatment: [The Ordinary Niacinamide 10% + Zinc 1%](https://lovi.care/skincare/fr/p/the-ordinary/niacinamide-10-zinc-1/for/acne-prone-skin) — Superior fit — €5.75 at Amazon

## Where to buy

- Amazon.fr: €29.49 (https://www.amazon.fr/dp/B00CVZ3NJ2?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- Notino: €6.70 (https://www.notino.fr/clinique/3-steps-emulsion-hydratante-pour-peaux-seches-a-tres-seches/p-67230/)
- Lookfantastic: €45.71 (https://www.lookfantastic.fr/p/clinique-dramatically-different-moisturising-lotion-200ml/13221005/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Mineral Oil, Paraffinum Liquidum, Huile Minérale, Glycerin, Petrolatum, Stearic Acid, Glyceryl Stearate, Sesamum Indicum Oil, Urea, Lanolin Alcohol, Triethanolamine, Hordeum Vulgare Extract, Extrait Dorge, Cucumis Sativus Fruit Extract, Helianthus Annuus Seedcake Sunflower Seedcake, Propylene Glycol Dicaprate, Sodium Hyaluronate, Butylene Glycol, Pentylene Glycol, Trisodium Edta, Phenoxyethanol, Ci 15985, Yellow 5 Ci 19140, Red 33 Ci 17200
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin (this page)
- Italy: https://lovi.care/skincare/it/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/clinique/dramatically-different-moisturizing-lotion/for/acne-prone-skin