# CLEARSTEM CELLRENEW Serum for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [CLEARSTEM](https://lovi.care/skincare/fr/brands/clearstem)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other serums fit it better.

## Why this fit

- This serum offers moderate benefits for your normal skin, with antioxidants and sodium hyaluronate providing hydration and protection, though these are not specifically targeted for your main goal of pigmentation.
- Camellia sinensis and aloe barbadensis contribute to soothing and antioxidant effects, which are generally beneficial for normal skin.
- The product is safe for your skin, as it contains no harsh ingredients and includes soothing components like Camellia Sinensis and Aloe Barbadensis.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Ganoderma Lucidum, Bio-Available Collagen Cells Stem, Antioxidants, Curcuma Longa

## What the research says

- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Small extracellular vesicles derived from Aloe vera peels exhibited antioxidant activity, reduced intracellular ROS levels, enhanced human skin cell migration, and upregulated antioxidant-related gene expression in H2O2-treated human keratinocytes. ([Tissue Engineering and Regenerative Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34313971/))
- Ferulic acid exhibits low toxicity, diverse physiological functions including antioxidant and anti-inflammatory effects, and protects skin structures, though its application is limited by rapid oxidation. ([Skin Pharmacology and Physiology, 2018](https://pubmed.ncbi.nlm.nih.gov/30235459/))
- Topical application of (-)-epigallocatechin-3-gallate (EGCG) to human skin before UV irradiation decreases UV-induced production of hydrogen peroxide by 68-90% and nitric oxide by 30-100%, inhibits leukocyte infiltration and lipid peroxidation by 41-84%, and restores glutathione levels and glutathione peroxidase activity compared to UV exposure alone. ([Carcinogenesis, 2001](https://pubmed.ncbi.nlm.nih.gov/11181450/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of soap enriched with Ganoderma lucidum and goat's milk for 3 days resulted in almost complete regression of annular cutaneous sarcoidosis lesions in a 44-year-old male patient. ([Dermatology and Therapy, 2016](https://pubmed.ncbi.nlm.nih.gov/26868374/))
- Ganoderma lucidum polysaccharides at concentrations of 10, 20, and 40 ΓΖg/mL significantly increased fibroblast viability, migration, and CICP and TGF-Β1 expression compared to the control group, and external use in mice significantly increased wound healing rates and reduced healing time. ([Chinese Journal of Integrative Medicine, 2019](https://pubmed.ncbi.nlm.nih.gov/30552545/))
- Ethanolic extracts of Ganoderma lucidum rich in triterpenoids and phenolic acids exhibit antioxidant, anti-inflammatory, antityrosinase, antimicrobial, and cytotoxic effects, and can be successfully incorporated into topical cosmeceutical formulations while preserving their bioactivities. ([Food and Chemical Toxicology, 2017](https://pubmed.ncbi.nlm.nih.gov/28760544/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))

## Why other serums fit skin with dark spots better

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

Based on a very large amount of data, users with acne-prone, sensitive, and reactive skin highly praise this product for calming inflammation, improving hydration, and supporting skin barrier repair. Many report smoother texture and reduced redness. Some users note it is a gentle, long-term support product rather than an overnight solution for deep-seated skin concerns.

- Liked: Acne-safe formula (mostly mentioned)
- Liked: Calms inflammation (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Deeply hydrating (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Slow visible results (sometimes noted)
- Disliked: Insufficient for severe acne (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does CLEARstem CELLRENEW work for skin with dark spots?

This serum works moderately well for your skin, providing hydration and protection with antioxidants and sodium hyaluronate, though it lacks ingredients specifically targeted for dark spots. Products that fit this skin better need a blend of effective antioxidants and soothing ingredients like niacinamide and propolis to fade pigmentation without irritation while keeping skin calm and smooth.
Sources: [Carcinogenesis, 2001](https://pubmed.ncbi.nlm.nih.gov/11181450/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Which ingredients make this serum a good fit for skin with dark spots?

Sodium hyaluronate, antioxidants, and turmeric help hydrate and protect your skin, though this treatment needs targeted brightening ingredients and potent antioxidants to truly fade dark spots.
Sources: [Carcinogenesis, 2001](https://pubmed.ncbi.nlm.nih.gov/11181450/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### What does Hyaluronic Acid do for skin with dark spots?

Hyaluronic acid is unlikely to directly fade dark spots, but it helps keep dry and uneven skin plump and deeply hydrated. To effectively target dark spots, this type of skin needs brightening ingredients like vitamin C or niacinamide alongside your hydrator.

### What does Reishi Mushroom Extract do for skin with dark spots?

Reishi Mushroom Extract helps reduce dark spots by lowering pigment production and calming the skin. It contains active compounds that safely target the pathways responsible for uneven tone and discoloration.
Sources: [Journal of Cellular Physiology, 2019](https://pubmed.ncbi.nlm.nih.gov/31115052/), [International Journal of Molecular Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27801787/)

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment serum goes in the evening routine for simplicity and extra safety around sun exposure. A serum for skin with dark spots needs brightening ingredients and targeted antioxidants to help fade uneven tone.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your normal skin hydration and protection from its antioxidants, followed by your retinol. The product is safe to use and unlikely to irritate your skin, as it contains soothing ingredients like camellia sinensis and aloe barbadensis.

### How often should I use this serum?

Apply this serum in your evening routine, as treatments fit best there for simplicity and extra safety around sun exposure. Skin with dark spots needs dedicated brightening ingredients like vitamin C, niacinamide, or alpha arbutin to effectively target uneven tone.

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to clog pores or cause breakouts because it contains no harsh ingredients and includes soothing components like Camellia Sinensis and Aloe Barbadensis. However, because it is an average fit for skin with dark spots, a product of this type needs targeted ingredients like vitamin C or niacinamide to properly fade dark spots while keeping your skin calm.
Sources: [Carcinogenesis, 2001](https://pubmed.ncbi.nlm.nih.gov/11181450/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — €57.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dark-spots) — High fit — €18.25 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/fr/p/la-mer/the-regenerating-serum/for/dark-spots) — High fit — €25.57 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/fr/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €11.35 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/fr/p/la-mer/the-tonic/for/dark-spots) — Superior fit — €10.25 at Amazon
- Moisturizer: [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/fr/p/isntree/green-tea-fresh-serum/for/dark-spots) — Superior fit — €12.56 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Antioxidants, Camellia Sinensis, Sodium Hyaluronate, Ganoderma Lucidum, Curcuma Longa, Trifolium Pratense, Peppermint Essence, Curcuma Extract, Aloe Barbadensis, Panthenol B5, Bio-Available Collagen Cells Stem, Kunzea Pomifera Fruit Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/clearstem/cellrenew-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/clearstem/cellrenew-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/clearstem/cellrenew-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/clearstem/cellrenew-serum/for/dark-spots
- France: https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/dark-spots (this page)
- Italy: https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/clearstem/cellrenew-serum/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/clearstem/cellrenew-serum/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/clearstem/cellrenew-serum/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/clearstem/cellrenew-serum/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/clearstem/cellrenew-serum/for/dark-spots