# Biotulin Supreme Skin Gel for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Biotulin](https://lovi.care/skincare/fr/brands/biotulin)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate plumping for your combination skin due to Sodium Hyaluronate and Glycerin, which hydrate and smooth texture, while Imperata Cylindrica Root Extract supports overall hydration.
- The formula provides general skincare benefits suitable for combination skin and oily shine, though it is not specialized for targeting these specific concerns.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/oily-acne-prone-skin): Average

## Key ingredients

Acmella Oleracea Extract, Imperata Cylindrica Root Extract, Sodium Hyaluronate, Vitis Vinifera Leaf Extract Grape Leaf Extract, Spilanthol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- An all-natural anti-wrinkle emulsion serum containing Acmella oleracea extract demonstrated safe skin tolerability and reduced facial wrinkles in human volunteers after 2 weeks of application. ([International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- An Acmella oleracea extract-loaded glycolipid emulsion serum applied topically demonstrated safety with no ocular irritation or systemic dermal absorption, alongside significant improvements in facial skin hydration, smoothness, and reductions in roughness, scaliness, and wrinkles. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/))
- A novel formulation containing supramolecular retinol plus acmella oleracea extract significantly reduced dark circles by 13.8% in melanin index, decreased fine wrinkles, and increased skin firmness by 13.0% in 33 Chinese urban women after 6 weeks of use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34806292/))
- The optimized squalane-based spilanthol emulsion achieved a maximum skin retention of 118.71 μg/g and restored skin hydroxyproline content to 23.99 μg/g, outperforming positive and negative groups due to high drug release and miscibility driven by weak Van der Waals interactions. ([AAPS PharmSciTech, 2019](https://pubmed.ncbi.nlm.nih.gov/31222590/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A combination of Vitis vinifera shoot extract and a biotechnological extract demonstrated significant in vitro and in vivo antioxidant effects and improved clinical signs of photoaged skin in female subjects after a 4-week application. ([Journal of Drugs in Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17691204/))
- Pre-treatment with Vitis vinifera L. water extract (100 ΓΙg/mL) demonstrated antioxidant and scavenger activity against UV-A radiation and exerted an anti-mutagenic effect by maintaining apoptosis in UV-A and UV-B irradiated human keratinocytes (HaCaT). ([Journal of Photochemistry and Photobiology. B, Biology, 2020](https://pubmed.ncbi.nlm.nih.gov/32028189/))
- A water extract from grapevine leaves inhibited proinflammatory-induced interleukin-8 and vascular endothelial growth factor secretion in human keratinocytes compared to untreated challenged cells. ([Antioxidants, 2019](https://pubmed.ncbi.nlm.nih.gov/31100904/))

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Biotulin Supreme Skin Gel work for combination skin?

Biotulin Biotulin Supreme Skin Gel works moderately well for combination skin, offering safe hydration and smoothing texture without irritation. A treatment for this skin needs effective ingredients like niacinamide and propolis or zinc PCA that regulate oiliness, enhance radiance, and provide optimal balance without excess oil or dryness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/)

### Which ingredients make this gel a good fit for combination skin?

This gel fits your combination skin because Sodium Hyaluronate and glycerin smooth your skin texture and add moderate hydration, while Imperata Cylindrica Root Extract supports overall moisture levels. To be a better fit for this skin type, a product needs ingredients like niacinamide, propolis, or zinc PCA that regulate oiliness, enhance radiance, and balance both dry and oily areas without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/)

### What does Acmella Oleracea Extract do for combination skin?

Acmella oleracea extract helps smooth and firm the skin while keeping it hydrated. It is generally well-tolerated and may help reduce wrinkles and roughness with regular use.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/), [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/)

### What does Imperata Cylindrica Root Extract do for combination skin?

Imperata cylindrica root extract is unlikely to provide enough hydration for combination skin on its own. A product of this type needs added water-binding ingredients and lightweight hydrators to properly balance oily and dry areas.
Sources: [BioMed Research International, 2021](https://pubmed.ncbi.nlm.nih.gov/34708121/)

### Where does this gel go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Putting it in the evening helps keep things simple and protects your skin around sun exposure. Combination skin works best with treatments that provide lightweight hydration and balance oily shine using ingredients like hyaluronic acid, glycerin, and plant extracts.

### Can I use this gel with retinol, and in what order?

You can use this gel in the evening after your cleanser and before your moisturizer, keeping retinol for your evening routine on alternating nights or applying it after this gel is fully absorbed. This product is unlikely to irritate your combination skin, but to get a better fit for this skin type, a product of this type needs specialized ingredients that target oily shine and balance combination areas.

### How often should I use this gel?

You can use this treatment in your evening routine, as well as in the morning or twice a day if your skin tolerates it well. To work better for combination skin, a product of this type needs ingredients that balance oily shine while providing targeted hydration.

### Can this gel clog pores, cause breakouts or purging for combination skin?

This gel is unlikely to cause breakouts or clog pores on combination skin, as it has a safe formula without harsh ingredients. To better fit combination skin, a product of this type needs specialized ingredients that deeply balance oily shine and target specific skin concerns.

### Is this gel fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — €18.25 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/fr/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €35.99 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/fr/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €389.34 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice RESIST Perfectly Balanced Foaming Cleanser](https://lovi.care/skincare/fr/p/paula-s-choice/perfectly-balanced-foaming-cleanser/for/combination-skin) — Superior fit — €32.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/fr/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/fr/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €17.47 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Butylene Glycol, Alcohol, Imperata Cylindrica Root Extract, Acmella Oleracea Extract, Xanthan Gum, Chondrus Crispus, Benzoic Acid, Phenoxyethanol, Vitis Vinifera Leaf Extract Grape Leaf Extract, Sodium Hyaluronate, Sodium Hydroxide, Carbomer, Caprylyl Glycol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Dehydroacetic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biotulin/supreme-skin-gel/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/biotulin/supreme-skin-gel/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/combination-skin
- France: https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/combination-skin (this page)
- Italy: https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/biotulin/supreme-skin-gel/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/biotulin/supreme-skin-gel/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/biotulin/supreme-skin-gel/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/biotulin/supreme-skin-gel/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/biotulin/supreme-skin-gel/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biotulin/supreme-skin-gel/for/combination-skin