# Avène Cleanance Comedomed Anti-Blemish Concentrate for sensitive skin

**Lovi Fit: Low fit for sensitive skin.**
Normal Skin Fit: Superior · Effectiveness: Average · Safety: Concerning.

Page: https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Avène](https://lovi.care/skincare/fr/brands/avene)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for sensitive skin; the serums alongside fit it better.

## Why this fit

- Offers moderate treatment for your acne-prone skin as isopropyl alcohol and silybum marianum fruit extract help reduce blemishes, though the latter is better suited for normal skin types.
- Avène Thermal Spring Water provides some soothing benefits for redness, but the presence of isopropyl alcohol and polyacrylate-13 poses a risk of worsening your sensitivity.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin): Low (this page)
- [Acne-prone skin](https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/oily-acne-prone-skin): Average

## Key ingredients

Avène Thermal Spring Water, Silybum Marianum Fruit Extract, Glycerin, Isopropyl Alcohol, Silica

## What the research says

- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37675655/))
- Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36204969/))
- Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris. ([Journal of Cutaneous Medicine and Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/37942562/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- The use of 70% isopropyl alcohol in conjunction with scrubbing with a bristled brush significantly reduced positive bacterial cultures at the nail fold compared to povidone-iodine with soft sponges in volunteers. ([The Journal of Bone and Joint Surgery. American Volume, 2005](https://pubmed.ncbi.nlm.nih.gov/15866960/))
- Friction with 70% ethyl or isopropyl alcohol immediately eliminates the heart-shaped pigmented lesion characteristic of terra firma-forme dermatosis in a 14-year-old boy. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38826967/))
- Rubbing 70% isopropyl alcohol wipes cleared persistent reticulated brown patches in five patients with terra firma-forme dermatosis. ([Skinmed, 2016](https://pubmed.ncbi.nlm.nih.gov/27871345/))
- A functional cosmetic cream containing bioactive materials from Streptomyces sp. T65 embedded in SBA-15 decreased skin roughness by 4.670% and increased skin brightness by 0.472% after 4 weeks of application, while demonstrating antimicrobial, antioxidant, anti-aging, and whitening activities. ([Antioxidants, 2020](https://pubmed.ncbi.nlm.nih.gov/32224894/))
- Film-forming formulations containing porous silica achieved skin permeation rates comparable to immediate release formulations while confirming prolonged drug availability and causing no skin irritation in healthy volunteers. ([European Journal of Pharmaceutical Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/28546105/))
- Topical treatment with silica mud and microalgae extracts from the Blue Lagoon improved skin barrier function by inducing epidermal gene expression and reducing transepidermal water loss in healthy humans, while preventing skin aging markers in vitro. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18312388/))

## What reviewers say

Based on a very large amount of data, this concentrate is highly effective for oily and acne-prone skin, significantly reducing active breakouts and preventing future blemishes. Users frequently praise its lightweight, fast-absorbing, and mattifying texture. A strong alcohol scent is commonly noted, and some users experience initial dryness or purging.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Reduces blemishes (mostly mentioned)
- Disliked: Strong alcohol scent (mostly mentioned)
- Liked: Controls oil (often mentioned)
- Liked: Prevents breakouts (sometimes noted)
- Disliked: Drying or peeling (sometimes noted)
- Disliked: Initial skin purging (rarely noted)
- Disliked: Stinging sensation (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why is Cleanance Comedomed Anti-Blemish Concentrate a weak match for sensitive skin?

This treatment is a weak match for your sensitive skin because isopropyl alcohol and polyacrylate-13 may trigger irritation and worsen your sensitivity. While it contains soothing Avène Thermal Spring Water and blemish-reducing ingredients, a treatment of this type needs calming agents, hydrators, and gentle ingredients that soothe redness and irritation without any risk of irritating sensitive skin.

### Which ingredients make this treatment a poor fit for sensitive skin?

This treatment is a weak fit for sensitive skin mainly because it contains isopropyl alcohol and polyacrylate-13, which pose a risk of worsening your sensitivity. A product for this skin needs soothing ingredients that calm redness and irritation, provide gentle hydration, and contain no harsh alcohols or potential allergens.

### What does Avène Thermal Spring Water do for sensitive skin?

Avène Thermal Spring Water helps calm sensitive skin by significantly reducing redness, stinging, and burning sensations. It provides a soothing effect and improves overall skin comfort, making it very well tolerated by easily irritated skin.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2020](https://pubmed.ncbi.nlm.nih.gov/32870553/), [Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348993/)

### What does Milk Thistle Fruit Extract do for sensitive skin?

Milk thistle fruit extract helps calm sensitive skin and reduce redness while protecting against daily damage with very high safety and comfort. This type of ingredient needs to offer soothing and antioxidant benefits to keep easily irritated skin smooth and comfortable.
Sources: [International Immunopharmacology, 2007](https://pubmed.ncbi.nlm.nih.gov/17996674/), [Giornale Italiano Di Dermatologia E Venereologia, 2020](https://pubmed.ncbi.nlm.nih.gov/29192469/)

### Where does this treatment go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing, though it is a weak match for sensitive skin. Sensitive skin needs gentle, soothing ingredients like glycerin and thermal spring water to calm redness without the risk of irritation from drying alcohols.

### Can I use this treatment with retinol, and in what order?

This treatment is a weak match for your sensitive skin because ingredients like isopropyl alcohol may worsen your redness and irritation, so a product of this type needs gentle, soothing plant extracts and extra hydration to keep skin calm and smooth.

### How often should I use this treatment?

This treatment is a weak match for sensitive skin, so it poses a risk of worsening your sensitivity if used too often. When trying an acne product of this type on sensitive skin, start by using it just once a week in the evening, then carefully increase the frequency only if your skin tolerates it well.

### Can this treatment clog pores, cause breakouts or purging for sensitive skin?

This treatment may cause drying, peeling, or initial breakouts because it contains isopropyl alcohol, which poses a risk of worsening sensitivity. A treatment for sensitive skin needs soothing ingredients like glycerin and thermal spring water without harsh drying alcohols to keep skin calm and soft.

### Is this treatment fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (isopropyl alcohol).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SKIN1004 Madagascar Centella Probio-cica Intensive Ampoule](https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/sensitive-skin) — Superior fit — €18.65 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €139.99 at Amazon

## Routine for sensitive skin

### AM

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €28.02 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/fr/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €27.60 at Amazon
- Moisturizer with Sun Protection: [innisfree Daily Mild Sunscreen](https://lovi.care/skincare/fr/p/innisfree/daily-mild-sunscreen/for/sensitive-skin) — Superior fit — €24.00 at Amazon

### PM

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/fr/p/missha/ultra-hyalon-cleansing-cream/for/sensitive-skin) — Superior fit — €16.10 at Amazon
- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €28.02 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/fr/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €27.60 at Amazon
- Serum or Treatment: [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/sensitive-skin) — Superior fit — €20.46 at Amazon

### Weekly

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/fr/p/missha/ultra-hyalon-cleansing-cream/for/sensitive-skin) — Superior fit — €16.10 at Amazon
- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €28.02 at Amazon
- Enzyme Powder: [Fancl Facial Washing Powder](https://lovi.care/skincare/fr/p/fancl/facial-washing-powder/for/sensitive-skin) — Superior fit — €30.65 at Amazon
- Nourishing Mask: [Anua Heartleaf 77% Soothing Sheet Mask](https://lovi.care/skincare/fr/p/anua/heartleaf-77-soothing-sheet-mask/for/sensitive-skin) — Superior fit — €19.90 at Amazon
- Serum or Treatment: [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/sensitive-skin) — Superior fit — €20.46 at Amazon

## Where to buy

- Notino: €17.50 (https://www.notino.fr/avene/cleanance-comedomed-soin-intense-anti-imperfections-de-la-peau-a-tendance-acneique/p-16322754/)
- Lookfantastic: €19.79 (https://www.lookfantastic.fr/p/avene-cleanance-comedomed-intensive-anti-blemish-care-30ml/17308720/)
Prices checked 10 Oct 2026.

## Ingredients

Avène Thermal Spring Water Avène Aqua, Isopropyl Alcohol, Peg-6, Glycerin, Silybum Marianum Fruit Extract, Silica, Polyacrylate-13, Polyisobutene, Polysorbate 20, Sorbitan Isostearate, Water
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin (this page)
- Italy: https://lovi.care/skincare/it/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/avene/cleanance-comedomed-anti-blemish-concentrate/for/sensitive-skin