# Hexapeptide and pro-retinol

Page: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-pro-retinol

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Keep them apart

Use them at different times of day by applying your [pro-retinol](https://lovi.care/skincare/fr/ingredients/retinol) at night and your [hexapeptide](https://lovi.care/skincare/fr/ingredients/hexapeptide) in the morning to avoid extra skin irritation. Using both together can overwhelm your skin and cause redness because they are both very active anti-aging ingredients. You can fix this by using a gentler strength, or by putting more time between applying the two products.

- [All about hexapeptide](https://lovi.care/skincare/fr/ingredients/hexapeptide)
- [All about pro-retinol](https://lovi.care/skincare/fr/ingredients/pro-retinol)

### [Hexapeptide](https://lovi.care/skincare/fr/ingredients/hexapeptide) products

- [SkinCeuticals P-TOX](https://lovi.care/skincare/fr/p/skinceuticals/p-tox/for/mature-skin) — High fit — [€155.25 at Lookfantastic](https://www.lookfantastic.fr/p/skinceuticals-p-tiox-neuro-peptide-serum-30ml/15456548/)

### [Pro-retinol](https://lovi.care/skincare/fr/ingredients/retinol) products

- [L'Oreal Paris Revitalift](https://lovi.care/skincare/fr/p/l-oreal-paris/revitalift/for/oily-acne-prone-skin) — High fit — [€15.97 at Amazon](https://www.amazon.fr/dp/B0F99M3N8L?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use hexapeptide and pro-retinol together?

No, you should keep [hexapeptide](https://lovi.care/skincare/fr/ingredients/hexapeptide) and [pro-retinol](https://lovi.care/skincare/fr/ingredients/retinol) apart in your routine because combining them may increase skin irritation. Instead, alternate your usage by applying your retinoid in the evening and peptides in the morning.

### Which goes first, hexapeptide or pro-retinol?

Keep hexapeptide and pro-retinol apart in your routine because combining them may increase skin irritation. You can alternate usage by applying the retinoid in the PM and peptides in the AM.

### Are hexapeptide and pro-retinol good for sensitive skin?

Hexapeptide and strong retinoids should be kept apart in the same routine because combined stimulation may increase irritation, which is a concern for sensitive skin. You can alternate usage by applying the retinoid in the PM and peptides in the AM.

## Research on hexapeptide and pro-retinol

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019

## Other combinations

- Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/pro-retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Bio-placenta peptides and pro-retinol](https://lovi.care/skincare/fr/ingredients/bio-placenta-peptides-and-pro-retinol)
- Keep them apart: [Pro-retinol and collagen peptide](https://lovi.care/skincare/fr/ingredients/pro-retinol-and-collagen-peptide)
- Keep them apart: [Pro-retinol and copper peptide](https://lovi.care/skincare/fr/ingredients/pro-retinol-and-copper-peptide)
- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/fr/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-granactive-retinoid)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-retinoid-blend)
- Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/fr/ingredients/retinol-and-hexapeptide)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/fr/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-vitamin-a)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/fr/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/fr/ingredients/pro-retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Pro-retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/fr/ingredients/pro-retinol-and-palmitoyl-tripeptide-1)
- Keep them apart: [Pro-retinol and peptide-rich plasma](https://lovi.care/skincare/fr/ingredients/pro-retinol-and-peptide-rich-plasma)
- Keep them apart: [Pro-retinol and triple peptide blend](https://lovi.care/skincare/fr/ingredients/pro-retinol-and-triple-peptide-blend)
- Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-liposome)
- Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-microcapsule)
- Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/fr/ingredients/vitamin-c-and-hexapeptide)
- Depends on the strength: [Niacinamide and pro-retinol](https://lovi.care/skincare/fr/ingredients/niacinamide-and-pro-retinol)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/fr/ingredients/glycerin-and-hexapeptide)
- Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/fr/ingredients/niacinamide-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/fr/ingredients/panthenol-and-hexapeptide)
- Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/fr/ingredients/bakuchiol-and-hexapeptide)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-gaba)
- Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-silk-amino-acids)
- Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-taurine)
- Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/fr/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide)
- Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-citric-acid)
- Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/fr/ingredients/glycolic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/fr/ingredients/coenzyme-q10-and-hexapeptide)
- Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/fr/ingredients/green-tea-and-hexapeptide)
- Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/fr/ingredients/vitamin-e-and-hexapeptide)
- Keep them apart: [AHA blend glycolic and citric acids and pro-retinol](https://lovi.care/skincare/fr/ingredients/aha-blend-glycolic-and-citric-acids-and-pro-retinol)
- Keep them apart: [Pro-retinol and citric acid](https://lovi.care/skincare/fr/ingredients/pro-retinol-and-citric-acid)
- Keep them apart: [Glycolic acid and pro-retinol](https://lovi.care/skincare/fr/ingredients/glycolic-acid-and-pro-retinol)
- Keep them apart: [Pro-retinol and lactic acid](https://lovi.care/skincare/fr/ingredients/pro-retinol-and-lactic-acid)
- Keep them apart: [Pro-retinol and mandelic acid](https://lovi.care/skincare/fr/ingredients/pro-retinol-and-mandelic-acid)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/fr/ingredients/ceramide-building-complex-and-hexapeptide)
- Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-cholesterol)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-phytosterol)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/fr/ingredients/salicylic-acid-and-hexapeptide)
- Keep them apart: [Salicylic acid and pro-retinol](https://lovi.care/skincare/fr/ingredients/salicylic-acid-and-pro-retinol)
- Keep them apart: [Vitamin C and pro-retinol](https://lovi.care/skincare/fr/ingredients/vitamin-c-and-pro-retinol)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-bleach)
- Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-potassium-hydroxide)
- Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-polyvinyl-alcohol)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-copper)
- Keep them apart: [Benzoyl peroxide and pro-retinol](https://lovi.care/skincare/fr/ingredients/benzoyl-peroxide-and-pro-retinol)
- Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-magnesium)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/fr/ingredients/benzoyl-peroxide-and-hexapeptide)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/fr/ingredients/azelaic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/hexapeptide-and-pro-retinol
- United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-pro-retinol
- Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-pro-retinol
- Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-pro-retinol
- France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-pro-retinol (this page)
- Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-pro-retinol
- Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-pro-retinol
- Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-pro-retinol
- Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-pro-retinol
- Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-pro-retinol
- Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-pro-retinol
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-pro-retinol
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-pro-retinol