# Acetyl hexapeptide-3 and baking soda

Page: https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-baking-soda

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Keep them apart

Use them at different times of day, applying the peptide first and the [baking soda](https://lovi.care/skincare/fr/ingredients/baking-soda) later, because they clash in chemical balance. Baking soda is too alkaline, which destroys the anti-aging benefits of the peptides and makes them useless. The shopper can switch to a gentler cleanser or wait longer between using them.

- [All about acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3)
- [All about baking soda](https://lovi.care/skincare/fr/ingredients/baking-soda)

### [Acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3) products

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/fr/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [€30.95 at Amazon](https://www.amazon.fr/dp/B0C9DXGXZ3?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/fr/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [€18.29 at Amazon](https://www.amazon.fr/dp/B0BLHW7JZM?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [Medik8 Liquid Peptides](https://lovi.care/skincare/fr/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [€77.67 at Amazon](https://www.amazon.fr/dp/B0DDY3D3QW?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [La Mer The Treatment Lotion](https://lovi.care/skincare/fr/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit
- [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/fr/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit
- [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/fr/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit — [€10.58 at Amazon](https://www.amazon.fr/dp/B072JH13CD?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [Good Molecules Super Peptide Serum](https://lovi.care/skincare/fr/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [€29.34 at Amazon](https://www.amazon.fr/dp/B091MTKS35?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/fr/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [€87.95 at Amazon](https://www.amazon.fr/dp/B09FG8TJDD?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [La Mer The Renewal Oil](https://lovi.care/skincare/fr/p/la-mer/the-renewal-oil/for/mature-skin) — High fit
- [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/fr/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit — [€87.98 at Lookfantastic](https://www.lookfantastic.fr/p/estee-lauder-micro-essence-treatment-lotion-with-bio-ferment-various-sizes/13496500/)
- [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/fr/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit
- [La Mer The Eye Concentrate](https://lovi.care/skincare/fr/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit

### [Baking soda](https://lovi.care/skincare/fr/ingredients/baking-soda) products

- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/fr/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/sensitive-skin) — High fit — [€16.71 at Amazon](https://www.amazon.fr/dp/B09H73T814?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [HISTOLAB Soft Deep Cleansing Enzyme Powder Wash](https://lovi.care/skincare/fr/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/dark-spots) — High fit
- [Vichy Mineralizing Thermal Water](https://lovi.care/skincare/fr/p/vichy/mineralizing-thermal-water/for/sensitive-skin) — High fit — [€8.25 at Amazon](https://www.amazon.fr/dp/B003BT6HNQ?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use acetyl hexapeptide-3 and baking soda together?

No, you should keep [acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3) and [baking soda](https://lovi.care/skincare/fr/ingredients/baking-soda) apart in your routine because baking soda creates a highly alkaline environment that can destabilize the peptide.

### Which goes first, acetyl hexapeptide-3 or baking soda?

Keep acetyl hexapeptide-3 and baking soda apart in your routine, as alkaline environments may reduce the stability and activity of peptides. There are no products combining both ingredients.

### Are acetyl hexapeptide-3 and baking soda good for sensitive skin?

Keep acetyl hexapeptide-3 and baking soda apart in your routine because baking soda is too alkaline for peptides to remain stable. Lovi rates the fit as average.

## Research on acetyl hexapeptide-3 and baking soda

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013
- [Evaluation of vulvar irritancy potential of a menstrual pad containing sodium bicarbonate in short-term application](https://pubmed.ncbi.nlm.nih.gov/1658321/) Baking soda · The Journal of Reproductive Medicine, 1991

## Other combinations

- Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/adapalene-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid)
- Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/pro-retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/retinal-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-retinoid-blend)
- Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/tretinoin-and-acetyl-hexapeptide-3)
- Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/vitamin-a-and-acetyl-hexapeptide-3)
- Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/liposome-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-microcapsule)
- Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/vitamin-c-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-betaine)
- Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/glycerin-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/niacinamide-and-acetyl-hexapeptide-3)
- Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/panthenol-and-acetyl-hexapeptide-3)
- Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/bakuchiol-and-acetyl-hexapeptide-3)
- Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/arginine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-gaba)
- Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3)
- Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/taurine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-citric-acid)
- Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/glycolic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/lactic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3)
- Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/green-tea-and-acetyl-hexapeptide-3)
- Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/vitamin-e-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-cholesterol)
- Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-phytosphingosine)
- Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-phytosterol)
- Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-squalene)
- Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/salicylic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-bleach)
- Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide)
- Keep them apart: [Bio-placenta peptides and baking soda](https://lovi.care/skincare/fr/ingredients/bio-placenta-peptides-and-baking-soda)
- Keep them apart: [Collagen peptide and baking soda](https://lovi.care/skincare/fr/ingredients/collagen-peptide-and-baking-soda)
- Keep them apart: [Copper peptide and baking soda](https://lovi.care/skincare/fr/ingredients/copper-peptide-and-baking-soda)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/fr/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/fr/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Baking soda and palmitoyl pentapeptide-4](https://lovi.care/skincare/fr/ingredients/baking-soda-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Baking soda and palmitoyl tripeptide-1](https://lovi.care/skincare/fr/ingredients/baking-soda-and-palmitoyl-tripeptide-1)
- Keep them apart: [Peptide-rich plasma and baking soda](https://lovi.care/skincare/fr/ingredients/peptide-rich-plasma-and-baking-soda)
- Keep them apart: [Triple peptide blend and baking soda](https://lovi.care/skincare/fr/ingredients/triple-peptide-blend-and-baking-soda)
- Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol)
- Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/copper-and-acetyl-hexapeptide-3)
- Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/magnesium-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-zinc)
- Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3)
- Keep them apart: [Vitamin C and baking soda](https://lovi.care/skincare/fr/ingredients/vitamin-c-and-baking-soda)
- Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/fr/ingredients/azelaic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-protease)
- Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-baking-soda
- United Kingdom: https://lovi.care/skincare/uk/ingredients/acetyl-hexapeptide-3-and-baking-soda
- Ireland: https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-baking-soda
- Germany: https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-baking-soda
- France: https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-baking-soda (this page)
- Italy: https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-baking-soda
- Netherlands: https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-baking-soda
- Spain: https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-baking-soda
- Canada: https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-baking-soda
- Australia: https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-baking-soda
- Singapore: https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-baking-soda
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-baking-soda
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/acetyl-hexapeptide-3-and-baking-soda