# 2-Mercaptonicotinoyl glycine Page: https://lovi.care/skincare/fr/ingredients/2-mercaptonicotinoyl-glycine The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France. Treatment with 2-mercaptonicotinoyl glycine visibly fades immediate darkening, prevents new melanin production, and outcompetes numerous reference molecules against UV and high energy visible light-induced pigmentation. This gentle active suits most skin types best and typically arrives in light [serums](https://lovi.care/skincare/fr/ingredients/serum). It also layers easily into your daily routine. [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38372022/) [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38433524/) [Frontiers in Pharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/41142247/) This page shows 2-mercaptonicotinoyl glycine products with a Lovi page. For every product, and a routine built for your skin, use the Lovi app. ## All 2-mercaptonicotinoyl glycine products - La Roche-Posay · Exfoliant treatment: [Mela B3 Brightening Micro-Peeling Gel](https://lovi.care/skincare/fr/p/la-roche-posay/mela-b3-brightening-micro-peeling-gel/for/sensitive-skin) ## Questions and answers ### What does 2-mercaptonicotinoyl glycine do for the skin? 2-mercaptonicotinoyl glycine helps prevent skin darkening and tanning caused by UV rays and high energy visible light. It significantly reduces immediate tanning and inhibits new melanin production in the skin. [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38372022/) [Frontiers in Pharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/41142247/) ### How do you use 2-mercaptonicotinoyl glycine? You can use 2-mercaptonicotinoyl glycine topically to help prevent skin darkening caused by UV light and high-energy visible light. Clinical studies often test it at 0.5% or 1% concentrations. [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38372022/) [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38433524/) ### Should you use 2-mercaptonicotinoyl glycine in the morning or at night? Yes, you should use 2-mercaptonicotinoyl glycine in the morning, because it helps prevent UV and high energy visible light-induced skin darkening and pigmentation during the day. [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38372022/) [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38433524/) ### Can you use 2-mercaptonicotinoyl glycine every day? Yes, you can use 2-mercaptonicotinoyl glycine every day as it helps prevent UV-induced skin darkening and inhibits new melanin production. Clinical studies show that regular topical application significantly decreases pigmentation caused by UV and high energy visible light. [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38372022/) [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38433524/) ### Does 2-mercaptonicotinoyl glycine cause purging or irritation? There is no indication that 2-mercaptonicotinoyl glycine causes purging or irritation. The studies do not report any such side effects. ### Which skin types is 2-mercaptonicotinoyl glycine best for? 2-mercaptonicotinoyl glycine helps prevent UV and visible light-induced pigmentation in skin phototypes III and IV, as well as melanin-rich skin. It is suitable for individuals looking to reduce sun-induced darkening and tanning. [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38372022/) [Frontiers in Pharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/41142247/) ## Research on 2-mercaptonicotinoyl glycine - [2-Mercaptonicotinoyl glycine prevents UV-induced skin darkening and delayed tanning in healthy subjects: A randomized controlled clinical study](https://pubmed.ncbi.nlm.nih.gov/38372022/) 2-Mercaptonicotinoyl glycine · Journal of Cosmetic Dermatology, 2024 - [A Bayesian network meta-analysis of 14 molecules inhibiting UV daylight-induced pigmentation](https://pubmed.ncbi.nlm.nih.gov/38433524/) 2-Mercaptonicotinoyl glycine · Journal of the European Academy of Dermatology and Venereology, 2024 - [Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials](https://pubmed.ncbi.nlm.nih.gov/41142247/) 2-Mercaptonicotinoyl glycine · Frontiers in Pharmacology, 2025 ## Brands with 2-mercaptonicotinoyl glycine - French skincare: [La Roche-Posay](https://lovi.care/skincare/fr/brands/la-roche-posay) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every ingredient with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this ingredient guide: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/2-mercaptonicotinoyl-glycine - United Kingdom: https://lovi.care/skincare/uk/ingredients/2-mercaptonicotinoyl-glycine - Ireland: https://lovi.care/skincare/ie/ingredients/2-mercaptonicotinoyl-glycine - Germany: https://lovi.care/skincare/de/ingredients/2-mercaptonicotinoyl-glycine - France: https://lovi.care/skincare/fr/ingredients/2-mercaptonicotinoyl-glycine (this page) - Italy: https://lovi.care/skincare/it/ingredients/2-mercaptonicotinoyl-glycine - Netherlands: https://lovi.care/skincare/nl/ingredients/2-mercaptonicotinoyl-glycine - Spain: https://lovi.care/skincare/es/ingredients/2-mercaptonicotinoyl-glycine - Canada: https://lovi.care/skincare/ca/ingredients/2-mercaptonicotinoyl-glycine - Australia: https://lovi.care/skincare/au/ingredients/2-mercaptonicotinoyl-glycine - Singapore: https://lovi.care/skincare/sg/ingredients/2-mercaptonicotinoyl-glycine - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/2-mercaptonicotinoyl-glycine - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/2-mercaptonicotinoyl-glycine