# VR vs Sesderma Page: https://lovi.care/skincare/fr/compare/vr-vs-sesderma The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France. VR and Sesderma are distinguished skincare brands known for meeting evolving daily needs through considered design and meticulously engineered formulas. VR offers sensorial moisturizers best suited for combination, sensitive, and dry skin, with a standout [PDRN](https://lovi.care/skincare/fr/ingredients/pdrn) CREAM for acne-prone skin, whereas the Spanish brand Sesderma provides advanced [serums](https://lovi.care/skincare/fr/ingredients/serum) utilizing botanical [extracts](https://lovi.care/skincare/fr/ingredients/extract) and active compounds for sensitive, hyperpigmented, and aging skin types, featuring the Azelac RU Serum for acne-prone skin. Both brands refine skin texture and promote radiant complexions, though they differ in their origins, specific active ingredients, and sensory experiences. Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026. [skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html) This page compares some of the most popular VR and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg5d83ff0dcb). ### Popular VR vs Sesderma products #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€35.90 at Amazon](https://www.amazon.fr/dp/B00987RKWW?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1) #### VR - [PDRN CREAM](https://lovi.care/skincare/fr/p/vr/pdrn-cream/for/sensitive-skin) — High fit — [€18.43 at Amazon](https://www.amazon.fr/dp/B0H19N8CXR?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### VR or Sesderma: which is better? VR achieves a High fit for sensitive skin with its fragrance-free [PDRN](https://lovi.care/skincare/fr/ingredients/pdrn) CREAM, whereas Sesderma achieves a High fit for acne-prone skin and skin with dark spots using its Azelac RU [Serum](https://lovi.care/skincare/fr/ingredients/serum). ### What is the difference between VR and Sesderma? VR and Sesderma differ mainly in their skin type fits and formulas, as Lovi rates VR's PDRN CREAM at High for sensitive skin with no fragrance listed, while Sesderma's Azelac RU Serum is rated High for acne-prone skin and dark spots but contains fragrance. ### Which is more affordable, VR or Sesderma? Neither VR nor Sesderma lists pricing information for the products on this page, so affordability cannot be compared. ### Which causes fewer breakouts, VR or Sesderma? For acne-prone skin, Sesderma earns a High Lovi fit with its Azelac RU Serum, whereas VR's PDRN CREAM achieves an Average fit across the products on this page. [Azelaic acid](https://lovi.care/skincare/fr/ingredients/azelaic-acid) helps reduce acne breakouts, and Azelac RU Serum contains fragrance. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### Which brand was founded earlier, VR or Sesderma? Sesderma was founded in 1989 in Spain, whereas VR was founded later in 2018. ### Do VR products contain fragrance compared to Sesderma? VR has no fragrance listed in any of the products on this page, whereas the Azelac RU Serum by Sesderma includes fragrance. ### How well does the VR PDRN Cream suit sensitive skin compared to the Sesderma Azelac RU Serum? VR PDRN Cream achieves a High fit on sensitive skin, whereas Sesderma Azelac RU Serum reaches only an Average fit. Furthermore, the products on this page by VR list no fragrance in their ingredients, while the Azelac RU Serum by Sesderma includes fragrance. ## Research behind their key ingredients - [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000 - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid · Dermatologic Therapy, 2022 - [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002 - [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007 - [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004 - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007 - [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017 - [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) 5-ceramide complex · Skin Pharmacology and Physiology, 2022 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [Effects of Moringa oleifera Seed Oil on Cultured Human Sebocytes In Vitro and Comparison with Other Oil Types](https://pubmed.ncbi.nlm.nih.gov/37373478/) Moringa oleifera seed oil · International Journal of Molecular Sciences, 2023 - [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998 - [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025 - [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025 - [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021 - [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024 - [Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin](https://pubmed.ncbi.nlm.nih.gov/41758783/) 5-ceramide complex · Skin Pharmacology and Physiology, 2026 ## The brands - Skincare: [VR](https://lovi.care/skincare/fr/brands/vr) - Spanish skincare: [Sesderma](https://lovi.care/skincare/fr/brands/sesderma) ## More comparisons - [SKIN1004 vs VR](https://lovi.care/skincare/fr/compare/skin1004-vs-vr) - [SKIN1004 vs Sesderma](https://lovi.care/skincare/fr/compare/skin1004-vs-sesderma) - [Anua vs VR](https://lovi.care/skincare/fr/compare/anua-vs-vr) - [Anua vs Sesderma](https://lovi.care/skincare/fr/compare/anua-vs-sesderma) - [Medicube vs VR](https://lovi.care/skincare/fr/compare/medicube-vs-vr) - [Medicube vs Sesderma](https://lovi.care/skincare/fr/compare/medicube-vs-sesderma) - [The Ordinary vs VR](https://lovi.care/skincare/fr/compare/the-ordinary-vs-vr) - [The Ordinary vs Sesderma](https://lovi.care/skincare/fr/compare/the-ordinary-vs-sesderma) - [Beauty of Joseon vs VR](https://lovi.care/skincare/fr/compare/beauty-of-joseon-vs-vr) - [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/fr/compare/beauty-of-joseon-vs-sesderma) - [COSRX vs VR](https://lovi.care/skincare/fr/compare/cosrx-vs-vr) - [COSRX vs Sesderma](https://lovi.care/skincare/fr/compare/cosrx-vs-sesderma) - [CeraVe vs VR](https://lovi.care/skincare/fr/compare/cerave-vs-vr) - [CeraVe vs Sesderma](https://lovi.care/skincare/fr/compare/cerave-vs-sesderma) - [La Roche-Posay vs VR](https://lovi.care/skincare/fr/compare/la-roche-posay-vs-vr) - [La Roche-Posay vs Sesderma](https://lovi.care/skincare/fr/compare/la-roche-posay-vs-sesderma) - [Dr. Althea vs VR](https://lovi.care/skincare/fr/compare/dr-althea-vs-vr) - [Dr. Althea vs Sesderma](https://lovi.care/skincare/fr/compare/dr-althea-vs-sesderma) - [Some By Mi vs VR](https://lovi.care/skincare/fr/compare/some-by-mi-vs-vr) - [Some By Mi vs Sesderma](https://lovi.care/skincare/fr/compare/some-by-mi-vs-sesderma) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/vr-vs-sesderma - United Kingdom: https://lovi.care/skincare/uk/compare/vr-vs-sesderma - Ireland: https://lovi.care/skincare/ie/compare/vr-vs-sesderma - Germany: https://lovi.care/skincare/de/compare/vr-vs-sesderma - France: https://lovi.care/skincare/fr/compare/vr-vs-sesderma (this page) - Italy: https://lovi.care/skincare/it/compare/vr-vs-sesderma - Netherlands: https://lovi.care/skincare/nl/compare/vr-vs-sesderma - Spain: https://lovi.care/skincare/es/compare/vr-vs-sesderma - Canada: https://lovi.care/skincare/ca/compare/vr-vs-sesderma - Australia: https://lovi.care/skincare/au/compare/vr-vs-sesderma - Singapore: https://lovi.care/skincare/sg/compare/vr-vs-sesderma - Saudi Arabia: https://lovi.care/skincare/sa/compare/vr-vs-sesderma - United Arab Emirates: https://lovi.care/skincare/ae/compare/vr-vs-sesderma