# Sesderma vs NEOCUTIS

Page: https://lovi.care/skincare/fr/compare/sesderma-vs-neocutis

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Sesderma and NEOCUTIS are esteemed European skincare houses that offer targeted solutions for distinct complexions. The Spanish pioneer employs advanced [serums](https://lovi.care/skincare/fr/ingredients/serum) and meticulously engineered formulas featuring botanical [extracts](https://lovi.care/skincare/fr/ingredients/extract) and active compounds to suit sensitive, hyperpigmented, and aging skin types. Meanwhile, the Swiss brand relies on refined serums and moisturizers with deeply restorative properties to nurture mature, dry, and stressed skin. While both deliver radiant results, they differ through the former's focus on refining texture and the latter's emphasis on balanced, gentle care.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

NEOCUTIS is a Swiss skincare brand founded in 2003 and owned by Merz Holding GmbH & Co. KG since 2013.

[businesswire.com](https://www.businesswire.com/news/home/20260716926041/en/Merz-Completes-Inaugural-%E2%82%AC450-Million-Schuldschein-Loan-Issuance) [gcimagazine.com](https://www.gcimagazine.com/brands-products/skin-care/news/21870673/merz-to-purchase-neocutis)

This page compares some of the most popular Sesderma and NEOCUTIS products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg9d6fd848cf).

### Popular Sesderma vs NEOCUTIS products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€35.90 at Amazon](https://www.amazon.fr/dp/B00987RKWW?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)

#### NEOCUTIS

- [Bio Serum Firm](https://lovi.care/skincare/fr/p/neocutis/bio-serum-firm/for/mature-skin) — High fit
- [lumière](https://lovi.care/skincare/fr/p/neocutis/lumiere/for/dry-skin) — Average fit

## Questions and answers

### Sesderma or NEOCUTIS: which is better?

NEOCUTIS is a better match for dry, mature, and sensitive skin, earning a High fit from Lovi for those skin types across its products on this page. Sesderma earns a High fit from Lovi mainly for acne-prone skin and dark spots, though its [serum](https://lovi.care/skincare/fr/ingredients/serum) contains fragrance.

### What is the difference between Sesderma and NEOCUTIS?

NEOCUTIS fits dry sensitive skin with a High Lovi rating, whereas the products on this page by Sesderma give it a Low fit. Additionally, every product on the NEOCUTIS page lists no fragrance, while the Azelac RU Serum by Sesderma contains fragrance.

### Which is more affordable, Sesderma or NEOCUTIS?

The page facts do not mention the prices of Sesderma or NEOCUTIS, so it is not possible to tell which brand is more affordable.

### Which causes fewer breakouts, Sesderma or NEOCUTIS?

NEOCUTIS products on this page have an Average fit for acne-prone skin, while the Sesderma Azelac RU Serum ranges from Average to High fit for acne-prone skin. [Azelaic acid](https://lovi.care/skincare/fr/ingredients/azelaic-acid) helps reduce acne vulgaris symptoms.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which brand has been established longer, Sesderma or NEOCUTIS?

Sesderma has been established longer, having been founded in Spain in 1989, whereas NEOCUTIS was founded in Switzerland in 2003.

### Do any products from Sesderma or NEOCUTIS contain fragrance?

NEOCUTIS products on this page list no fragrance in their ingredients, whereas the Azelac RU Serum from Sesderma contains fragrance.

### In which countries were Sesderma and NEOCUTIS founded?

Sesderma was founded in Spain, whereas NEOCUTIS was founded in Switzerland.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid · Dermatologic Therapy, 2022
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalane · Scientific Reports, 2020
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tripeptide-1 acetate, Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 acetate, Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1 acetate · International Journal of Cosmetic Science, 2026

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/fr/brands/sesderma)
- Swiss skincare: [NEOCUTIS](https://lovi.care/skincare/fr/brands/neocutis)

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- [Medicube vs Sesderma](https://lovi.care/skincare/fr/compare/medicube-vs-sesderma)
- [Medicube vs NEOCUTIS](https://lovi.care/skincare/fr/compare/medicube-vs-neocutis)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/fr/compare/the-ordinary-vs-sesderma)
- [The Ordinary vs NEOCUTIS](https://lovi.care/skincare/fr/compare/the-ordinary-vs-neocutis)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/fr/compare/beauty-of-joseon-vs-sesderma)
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- [COSRX vs NEOCUTIS](https://lovi.care/skincare/fr/compare/cosrx-vs-neocutis)
- [CeraVe vs Sesderma](https://lovi.care/skincare/fr/compare/cerave-vs-sesderma)
- [CeraVe vs NEOCUTIS](https://lovi.care/skincare/fr/compare/cerave-vs-neocutis)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/fr/compare/la-roche-posay-vs-sesderma)
- [La Roche-Posay vs NEOCUTIS](https://lovi.care/skincare/fr/compare/la-roche-posay-vs-neocutis)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/fr/compare/dr-althea-vs-sesderma)
- [Dr. Althea vs NEOCUTIS](https://lovi.care/skincare/fr/compare/dr-althea-vs-neocutis)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/fr/compare/some-by-mi-vs-sesderma)
- [Some By Mi vs NEOCUTIS](https://lovi.care/skincare/fr/compare/some-by-mi-vs-neocutis)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-neocutis
- United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-neocutis
- Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-neocutis
- Germany: https://lovi.care/skincare/de/compare/sesderma-vs-neocutis
- France: https://lovi.care/skincare/fr/compare/sesderma-vs-neocutis (this page)
- Italy: https://lovi.care/skincare/it/compare/sesderma-vs-neocutis
- Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-neocutis
- Spain: https://lovi.care/skincare/es/compare/sesderma-vs-neocutis
- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-neocutis
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