# Sesderma vs Grown Alchemist

Page: https://lovi.care/skincare/fr/compare/sesderma-vs-grown-alchemist

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Sesderma and Grown Alchemist are distinct skincare brands founded in Spain in 1989 and known for advanced [serums](https://lovi.care/skincare/fr/ingredients/serum), cleansers, and meticulously engineered formulas. The former is beloved for botanical [extracts](https://lovi.care/skincare/fr/ingredients/extract) and active compounds that suit sensitive, hyperpigmented, and aging skin types best, featuring the Azelac RU Serum for acne-prone skin to refine texture and promote a radiant complexion. Meanwhile, the latter is loved for formulas that suit sensitive, dry, and combination skin best, highlighting standout options like the Hydra-Restore Cream Cleanser, Instant Smoothing Serum, and Gentle Gel Facial Cleanser for specific concerns. Both differ through their precise approaches, with the Spanish brand emphasizing specialized corrective results while the other focuses on botanical-driven daily care.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Sesderma and Grown Alchemist products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgaf304c8412).

### Popular Sesderma vs Grown Alchemist products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€35.90 at Amazon](https://www.amazon.fr/dp/B00987RKWW?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)

#### Grown Alchemist

- [Gentle Gel Facial Cleanser](https://lovi.care/skincare/fr/p/grown-alchemist/gentle-gel-facial-cleanser/for/dry-sensitive-skin) — Average fit
- [Hydra-Restore Cream Cleanser](https://lovi.care/skincare/fr/p/grown-alchemist/hydra-restore-cream-cleanser/for/sensitive-skin) — High fit — [€35.00 at Amazon](https://www.amazon.fr/dp/B00G3J8ISI?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [Instant Smoothing Serum](https://lovi.care/skincare/fr/p/grown-alchemist/instant-smoothing-serum/for/dry-sensitive-skin) — Average fit

## Questions and answers

### Sesderma or Grown Alchemist: which is better?

Grown Alchemist is generally better for sensitive or dry skin, where its Hydra-Restore Cream Cleanser reaches a High Lovi fit level, whereas Sesderma offers strong options like Azelac RU [Serum](https://lovi.care/skincare/fr/ingredients/serum) that has a High Lovi fit for acne-prone skin and dark spots. Grown Alchemist also keeps all the products on this page fragrance-free, unlike Sesderma's serum.

### What is the difference between Sesderma and Grown Alchemist?

Sesderma offers the Azelac RU Serum which has High fit for acne-prone skin and dark spots, while Grown Alchemist features the Hydra-Restore Cream Cleanser which has High fit across many skin types including dry sensitive and mature skin. Grown Alchemist products on this page list no fragrance, whereas Sesderma includes fragrance in its serum.

### Which is more affordable, Sesderma or Grown Alchemist?

Neither Sesderma nor Grown Alchemist shows pricing information on this page, so affordability cannot be compared here.

### Which causes fewer breakouts, Sesderma or Grown Alchemist?

Grown Alchemist fits acne-prone skin with a High level in its Hydra-Restore Cream Cleanser, whereas Sesderma achieves a High fit for acne-prone skin with its Azelac RU Serum. [Azelaic acid](https://lovi.care/skincare/fr/ingredients/azelaic-acid) helps reduce acne-prone breakouts.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which brand was founded earlier, Sesderma or Grown Alchemist?

Sesderma was founded earlier in 1989 in Spain, while Grown Alchemist was founded in 2008.

### Do both Sesderma and Grown Alchemist products contain fragrance?

Grown Alchemist has no fragrance listed in any of the products on this page, whereas Sesderma includes fragrance in its Azelac RU Serum.

### Which brand has products that achieve a High Lovi fit level for dry sensitive skin?

Grown Alchemist has products that achieve a High Lovi fit level for dry sensitive skin, specifically the Hydra-Restore Cream Cleanser. Sesderma products on this page only reach a Low fit for that skin type.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate](https://pubmed.ncbi.nlm.nih.gov/11766131/) Benzyl alcohol · International Journal of Toxicology, 2001
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate molecule · Dermatologic Therapy, 2022
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf extract · Clinical Pharmacology, 2018
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Efficacy of olive leaf extract-containing cream for facial rejuvenation: A pilot study](https://pubmed.ncbi.nlm.nih.gov/32333467/) Olive leaf extract · Journal of Cosmetic Dermatology, 2020
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors](https://pubmed.ncbi.nlm.nih.gov/33081083/) Rose bud · Molecules, 2020
- [Is benzyl alcohol a significant contact sensitizer?](https://pubmed.ncbi.nlm.nih.gov/35080274/) Benzyl alcohol · Journal of the European Academy of Dermatology and Venereology, 2022
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [Noninvasive evaluation of the influence of aucubin-containing cosmetic macroemulsion on selected skin parameters](https://pubmed.ncbi.nlm.nih.gov/32750209/) Plantago extract · Journal of Cosmetic Dermatology, 2021
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Rosa gallica and its active compound, cyanidin-3,5-O-diglucoside, improve skin hydration via the GLK signaling pathway](https://pubmed.ncbi.nlm.nih.gov/36573713/) Rose bud · BioFactors, 2023
- [Clinical efficacy of herbal extract cream on the skin hydration, elasticity, thickness, and dermis density for aged skin: A randomized controlled double-blind study](https://pubmed.ncbi.nlm.nih.gov/30636339/) Botanical extracts · Journal of Cosmetic Dermatology, 2019
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Influence of the emulsifier on nanostructure and clinical application of liquid crystalline emulsions](https://pubmed.ncbi.nlm.nih.gov/36918671/) Camellia seed oil · Scientific Reports, 2023
- [Development and efficacy assessments of tea seed oil makeup remover](https://pubmed.ncbi.nlm.nih.gov/27988044/) Camellia seed oil · Annales Pharmaceutiques Francaises, 2017
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Effects of fermented tea seed oil on the skin lipid barrier and microbiome of sensitive skin](https://pubmed.ncbi.nlm.nih.gov/41319188/) Camellia seed oil · International Journal of Cosmetic Science, 2026

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/fr/brands/sesderma)
- Skincare: [Grown Alchemist](https://lovi.care/skincare/fr/brands/grown-alchemist)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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