# Bioderma vs Sesderma

Page: https://lovi.care/skincare/fr/compare/bioderma-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Bioderma and Sesderma are respected European skincare houses offering specialized solutions for diverse complexions. The French pioneer, founded in 1977, is known for gentle moisturizers, soothing makeup removers, targeted [serums](https://lovi.care/skincare/fr/ingredients/serum), and purifying cleansers enriched with [glycerin](https://lovi.care/skincare/fr/ingredients/glycerin), suiting acne-prone and oily skin best through essentials like the Sensibio Gel Moussant, Sensibio Micellar Cleansing Oil, and Atoderm Intensive Eye. Meanwhile, the Spanish creator, established in 1989, is beloved for advanced serums and meticulously engineered formulas featuring botanical [extracts](https://lovi.care/skincare/fr/ingredients/extract) and active compounds that best suit sensitive, hyperpigmented, and aging skin types with standout items like the Azelac RU Serum. Ultimately, both brands differ in their geographical origins and founding eras, yet each thoughtfully formulates its offerings to refine texture, promote radiance, and improve hydration.

Bioderma is a French skincare brand founded in 1977 and owned by Jean-Noël Thorel Foundation since 2018.

[bioderma.us](https://www.bioderma.us/en/the-brand/the-naos-dematological-brand.html) [naos.com](https://naos.com/en/an-organization-with-an-altruistic-purpose/our-altruistic-purpose-model)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Bioderma and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgc45edccb5d).

### Popular Bioderma vs Sesderma products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€35.90 at Amazon](https://www.amazon.fr/dp/B00987RKWW?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)

#### Bioderma

- [Sensibio H2O](https://lovi.care/skincare/fr/p/bioderma/sensibio-h2o/for/combination-skin) — Average fit — [€18.03 at Amazon](https://www.amazon.fr/dp/B01DA53DAU?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [Atoderm Intensive Baume](https://lovi.care/skincare/fr/p/bioderma/atoderm-intensive-baume/for/dry-skin) — Average fit — [€23.50 at Amazon](https://www.amazon.fr/dp/B0161ZC5GY?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [Pigmentbio Sensitive Areas](https://lovi.care/skincare/fr/p/bioderma/pigmentbio-sensitive-areas/for/oily-acne-prone-skin) — High fit — [€39.70 at Notino](https://www.notino.fr/bioderma/pigmentbio-sensitive-areas-creme-blanchissante-visage-et-zones-sensibles/p-16277872/)
- [Sébium Hydra](https://lovi.care/skincare/fr/p/bioderma/sebium-hydra/for/dry-skin) — High fit — [€13.95 at Amazon](https://www.amazon.fr/dp/B081V216Y9?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [Sébium Pore Refiner](https://lovi.care/skincare/fr/p/bioderma/sebium-pore-refiner/for/acne-prone-skin) — Average fit — [€13.00 at Amazon](https://www.amazon.fr/dp/B0G8JPVLTN?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [Sensibio Micellar Cleansing Oil](https://lovi.care/skincare/fr/p/bioderma/sensibio-micellar-cleansing-oil/for/dry-skin) — Superior fit — [€21.30 at Amazon](https://www.amazon.fr/dp/B0GQN7D5SV?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [Sensibio Gel Moussant](https://lovi.care/skincare/fr/p/bioderma/sensibio-gel-moussant/for/acne-prone-skin) — High fit — [€15.80 at Amazon](https://www.amazon.fr/dp/B01I4OSYJ2?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
- [Sébium Gel moussant](https://lovi.care/skincare/fr/p/bioderma/sebium-gel-moussant/for/oily-skin) — High fit — [€19.50 at Amazon](https://www.amazon.fr/dp/B002W5GPFA?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Bioderma or Sesderma: which is better?

Bioderma offers a much wider variety of products across this page with high Lovi fit levels for sensitive and acne-prone skin, whereas Sesderma is represented by only a single [serum](https://lovi.care/skincare/fr/ingredients/serum). Reviewers frequently note that Bioderma's products are effective and soothing, though some mention high prices and occasional texture issues.

### What is the difference between Bioderma and Sesderma?

Bioderma offers a wide range of twenty products featuring key ingredients like [glycerin](https://lovi.care/skincare/fr/ingredients/glycerin) and golden seaweed, whereas Sesderma is represented by only one product on this page, Azelac RU Serum. Reviewers frequently note Bioderma for its soothing and barrier-repairing moisturizers as well as gentle makeup removers.

### Which is more affordable, Bioderma or Sesderma?

Bioderma offers a wide range of products on this page, but some reviewers note concerns regarding its high price point, whereas Sesderma is represented by only one product here, making direct affordability comparisons difficult.

### Which causes fewer breakouts, Bioderma or Sesderma?

Bioderma offers multiple products on this page with a high Lovi fit for acne-prone skin, such as Sébium Mat Control, while Sesderma has only one featured product, Azelac RU Serum, which also achieves a high fit for acne-prone skin.

### Which brand has been around longer and in which countries were they founded?

Bioderma has been around longer, having been founded in France in 1977, whereas Sesderma was founded in Spain in 1989.

### How many products from Bioderma and Sesderma list fragrance on this page?

On this page, eleven of the twenty Bioderma products and all of the Sesderma products list fragrance.

### What are some of the common pros and cons reported by reviewers regarding Bioderma products?

Reviewers of Bioderma products on this page mostly mention soothing and barrier-repairing moisturizers, gentle makeup removers, and effective cleansers. Some note cons such as high price points, texture issues like stickiness, unpleasant fragrances, and that the products can sometimes be drying.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate, Hyaluronic acid · Dermatologic Therapy, 2022
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/18489348/) Phytosphingosine · International Journal of Cosmetic Science, 2007
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Topical Mannitol Reduces Capsaicin-Induced Pain: Results of a Pilot-Level, Double-Blind, Randomized Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/25978942/) Mannitol · PM & R, 2015
- [Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin](https://pubmed.ncbi.nlm.nih.gov/27349297/) Xylitol · Acta Dermato-venereologica, 2017
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Tocopherol, Tocopherol vitamin e · Journal of Cosmetic Dermatology, 2020
- [Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo](https://pubmed.ncbi.nlm.nih.gov/25381913/) Licorice root extract, Glycyrrhiza glabra root extract licorice root extract · Experimental Dermatology, 2015
- [Hesperidin, Hesperetin, Rutinose, and Rhamnose Act as Skin Anti-Aging Agents](https://pubmed.ncbi.nlm.nih.gov/36838716/) Rhamnose · Molecules, 2023
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Development of Polymeric Micelles of Oleanolic Acid and Evaluation of Their Clinical Efficacy](https://pubmed.ncbi.nlm.nih.gov/32572634/) Micellar technology · Nanoscale Research Letters, 2020
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Effect of topically applied lipids on surfactant-irritated skin](https://pubmed.ncbi.nlm.nih.gov/8746332/) Brassica campestris seed oil · The British Journal of Dermatology, 1996
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial](https://pubmed.ncbi.nlm.nih.gov/25914553/) Ginkgo biloba leaf extract, Mannitol · Clinical, Cosmetic and Investigational Dermatology, 2015
- [Potentially beneficial effects of rhamnose on skin ageing: an in vitro and in vivo study](https://pubmed.ncbi.nlm.nih.gov/30845349/) Rhamnose · International Journal of Cosmetic Science, 2019
- [Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study](https://pubmed.ncbi.nlm.nih.gov/36698447/) Zinc gluconate · Clinical, Cosmetic and Investigational Dermatology, 2023
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)](https://pubmed.ncbi.nlm.nih.gov/11278060/) Sodium laureth sulfate · Food and Chemical Toxicology, 2001
- [The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study](https://pubmed.ncbi.nlm.nih.gov/36729399/) Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023
- [Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/33617668/) Citric acid · Journal of Cosmetic Dermatology, 2021
- [Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters](https://pubmed.ncbi.nlm.nih.gov/37539499/) Mannitol · Journal of Cosmetic Dermatology, 2024
- [Formulation strategies to modulate the topical delivery of anti-inflammatory compounds](https://pubmed.ncbi.nlm.nih.gov/24139433/) Stearyl glycyrrhetinate · Journal of Cosmetic Science, 2013
- [Stability, antioxidant activity, in vivo safety and efficacy of creams with standardized wild apple fruit extract: a comparison of conventional and biodegradable emulsifiers](https://pubmed.ncbi.nlm.nih.gov/31050807/) Pyrus malus fruit extract · International Journal of Cosmetic Science, 2019
- [Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids](https://pubmed.ncbi.nlm.nih.gov/12482041/) Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002
- [Salicyloyl-phytosphingosine: a novel agent for the repair of photoaged skin](https://pubmed.ncbi.nlm.nih.gov/18489360/) Phytosphingosine · International Journal of Cosmetic Science, 2007
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects](https://pubmed.ncbi.nlm.nih.gov/38336313/) Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024
- [Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation](https://pubmed.ncbi.nlm.nih.gov/37074796/) Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Xylitol · Molecules, 2021
- [Standardized wild apple fruit extract as a bioactive agent in dermocosmetic products for efficacy skin hydration-In vitro and in vivo evaluation](https://pubmed.ncbi.nlm.nih.gov/35048513/) Pyrus malus fruit extract · Journal of Cosmetic Dermatology, 2022
- [A new formula for a mild body cleanser: sodium laureth sulphate supplemented with sodium laureth carboxylate and lauryl glucoside](https://pubmed.ncbi.nlm.nih.gov/24617572/) Lauryl glucoside · International Journal of Cosmetic Science, 2014
- [Sodium hydroxide-induced subclinical irritation. A test for evaluating stratum corneum barrier function](https://pubmed.ncbi.nlm.nih.gov/1981416/) Sodium hydroxide · Acta Dermato-venereologica, 1990
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Chitosan derivative nanocarrier: safety evaluation,antibacterial property and ascorbyl palmitate encapsulation](https://pubmed.ncbi.nlm.nih.gov/19566395/) Ascorbyl palmitate · Journal of Microencapsulation, 2010
- [Evaulation of irritation potential of surfactant mixtures](https://pubmed.ncbi.nlm.nih.gov/18503452/) Sodium laureth sulfate · International Journal of Cosmetic Science, 1999
- [Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/23545907/) Citric acid · Journal of Drugs in Dermatology, 2013
- [Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study](https://pubmed.ncbi.nlm.nih.gov/41487026/) Zinc gluconate · Journal of Cosmetic Dermatology, 2026
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Fruit acids and sodium hydroxide in the food industry and their combined effect with sodium lauryl sulphate: controlled in vivo tandem irritation study](https://pubmed.ncbi.nlm.nih.gov/15541082/) Sodium hydroxide · The British Journal of Dermatology, 2004
- [Interest in Micellar Solution to Reduce Unpleasant Skin Sensations](https://pubmed.ncbi.nlm.nih.gov/34471366/) Micellar technology · Clinical, Cosmetic and Investigational Dermatology, 2021
- [Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study](https://pubmed.ncbi.nlm.nih.gov/42617898/) Sodium laureth sulfate · International Journal of Pharmaceutics, 2026
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026

## The brands

- French skincare: [Bioderma](https://lovi.care/skincare/fr/brands/bioderma)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/fr/brands/sesderma)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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