ZO Skin Health Eye Brightening Crème for dry sensitive skin

Questions and answers

What the research says

• Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.

  The British Journal of Dermatology, 2019

• Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.

  International Journal of Cosmetic Science, 2017

• Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.

  Journal of Controlled Release, 2018

• Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle.

  Archives of Dermatological Research, 2017

• A topical formulation containing kojic acid, emblica extract, and glycolic acid demonstrated efficacy parity compared with hydroquinone 4% in multiethnic participants with mild to moderate facial dyschromia.

  Cutis, 2010

• A nanoemulsion containing 1 mg/mL kojic dipalmitate and 5% rosehip oil demonstrated high incorporation efficiency, suitable physicochemical stability, antioxidant and depigmenting efficacy close to 1 mM ascorbic acid, and no cytotoxicity at concentrations from 0.06% to 1% in vitro.

  Pharmaceutics, 2023

• Topical application of iron chelators kojic acid and deferiprone significantly accelerated wound healing in rats compared to control groups, with deferiprone showing superior efficacy due to higher antioxidant and iron chelation abilities.

  International Wound Journal, 2013

• Gels containing 1% Arnica montana L. flower extract successfully enhanced the volume of the lips and face with a reduction of wrinkles in humans.

  International Journal of Cosmetic Science, 2023

• Topical application of Arnica montana ointment reduced the inflammatory response and oxidative damage in mice exposed to UVB radiation compared to untreated UVB-exposed skin.

  Cutaneous and Ocular Toxicology, 2020

• The protocol combining microcurrent with topical Arnica montana reduces inflammation, increases myofibroblast proliferation, and decreases macrophage presence in rats with skin lesions compared to controls.

  International Journal of Experimental Pathology, 2023

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks.

  International Journal of Cosmetic Science, 2011

• Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects.

  Frontiers in Physiology, 2019

• Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid.

  AAPS PharmSciTech, 2021

Ingredients

Retinol Vitamin A, Phenoxyethanol, Polysorbate-60, Peg-100 Stearate, Dimethicone, Polysorbate-20, Myristyl Myristate, Chlorphenesin, Sodium Benzoate, Glycerin, Arnica Montana Flower Extract, Kojic Dipalmitate, Hydrolyzed Sericin, Ethylhexylglycerin, Tromethamine, Potassium Sorbate, Ci 77499, Water, Butyrospermum Parkii Butter Shea Butter, Butylene Glycol, Cetyl Esters, Glyceryl Monostearate, Squalane, Cetearyl Alcohol, Dipentaerythrityl Hexa C5-9 Acid Esters, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Carbomer, Stearic Acid, Palmitic Acid, Sorbitan Stearate, Brassica Oleracea Italica Extract, Saccharomyces Lysate Extract, Glycine Soja Seed Extract Soybean Seed Extract, Buddleja Davidii Cell Culture, Tocopherol, Isostearyl Alcohol, Isostearyl Neopentanoate, Polyacrylate-22, Boron Nitride, Sodium Hyaluronate, Silica, Amorphous, Coenzyme A, Caffeine, Myristyl Laurate, Acrylates Dimethylaminoethyl Methacrylate Copolymer, Sodium Pca, Disodium Edta, Xanthan Gum, Carnitine, Caprylyl Glycol, Sodium Dehydroacetate, Titanium Dioxide

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.