# Youth To The People Polypeptide-121 Future Cream for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Youth To The People](https://lovi.care/skincare/es/brands/youth-to-the-people)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent suitability for your normal skin is provided by Hydrolyzed Hyaluronic Acid and Glycerin, which act as humectants, complemented by Ceramides and Phytosphingosine to repair your skin barrier.
- The formula offers excellent benefits for wrinkles and fine lines due to targeted ingredients like Sh-Polypeptide-121 and multiple Acetyl Tetrapeptides that promote collagen synthesis and skin elasticity.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of harsh ingredients and the presence of soothing components like aloe barbadensis leaf juice and bisabolol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Biotech Collagen, Hydrolyzed Hyaluronic Acid, Niacinamide, Acetyl Tetrapeptides, Aloe Barbadensis Leaf Juice

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of an emulsion containing a complete mixture of ceramides III, IIIB, VI, phytosphingosine, cholesterol, and linoleic acid significantly accelerated barrier recovery after SLS damage and improved skin hydration after acetone treatment in human volunteers compared to an emulsion containing only two types of ceramides. ([Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/))
- Treatment of immortalized human keratinocytes with Acetyl Tetrapeptide-2 increased cell stiffness across its concentration range, while Acetyl Hexapeptide-50 increased stiffness at 0.05 µg/ml but decreased it at 0.5 and 5 µg/ml compared to untreated controls. ([International Journal of Peptide Research and Therapeutics, 2018](https://pubmed.ncbi.nlm.nih.gov/30416406/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))

## What reviewers say

Based on a very large amount of data, users with dry and sensitive skin frequently praise this cream for its ability to provide deep, long-lasting hydration without feeling heavy, often describing a "dewy" and "plump" finish. Many appreciate its barrier-strengthening ingredients and lightweight texture under makeup. Some users with oily or acne-prone skin experienced breakouts, and others found the price point too high for the amount of product provided.

- Liked: Deep hydration (mostly mentioned)
- Liked: Lightweight texture (mostly mentioned)
- Liked: Makeup compatibility (often mentioned)
- Disliked: Expensive for size (often mentioned)
- Liked: Soothing formula (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Unhygienic packaging (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Youth To The People Polypeptide-121 Future Cream one of the best fits for mature skin?

Youth To The People Polypeptide-121 Future Cream is a superior fit for mature skin because it features targeted ingredients like Sh-Polypeptide-121 and multiple acetyl tetrapeptides that help promote collagen synthesis and improve skin elasticity, while ceramides and phytosphingosine repair the skin barrier. It also includes Hydrolyzed Hyaluronic Acid and glycerin to boost hydration, and soothing components like aloe barbadensis leaf juice and bisabolol ensure an excellent safety profile with no risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/)

### Which ingredients make this cream a good fit for mature skin?

Biotech collagen, hydrolyzed hyaluronic acid, niacinamide, and acetyl tetrapeptides make this cream a superior fit for mature skin by helping smooth wrinkles, restore firmness, and deeply hydrate. These targeted ingredients promote collagen production to improve skin elasticity and keep your face looking soft and smooth.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Peptide Research and Therapeutics, 2018](https://pubmed.ncbi.nlm.nih.gov/30416406/)

### What does Biotech Collagen do for mature skin?

Biotech Collagen helps smooth fine lines, firm up sagging areas, and keep mature skin feeling soft and deeply hydrated. It also improves overall skin elasticity and reduces the look of wrinkles.
Sources: [PloS One, 2025](https://pubmed.ncbi.nlm.nih.gov/40880343/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40686102/)

### What does Hydrolyzed Hyaluronic Acid do for mature skin?

Hydrolyzed hyaluronic acid helps mature skin by significantly boosting skin hydration, improving elasticity, and reducing the look of deep wrinkles. It is unlikely to cause irritation, making it a well-suited choice for keeping dry and aging skin looking smooth.
Sources: [Archives of Dermatological Research, 2024](https://pubmed.ncbi.nlm.nih.gov/38829483/), [Colloids and Surfaces. B, Biointerfaces, 2022](https://pubmed.ncbi.nlm.nih.gov/36279763/)

### Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment goes near the end of your routine, right before sunscreen in the morning and as the final step in the evening. It helps keep your skin soft and smooth while supporting elasticity and firmness.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this cream with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying the cream after your retinol step to help keep your skin calm and hydrated. Barrier-supporting ingredients like ceramides and soothing components make this combination unlikely to cause irritation while keeping your skin soft and smooth.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/)

### How often should I use this cream?

You can use this moisturizing treatment twice a day as part of your morning and evening routine. Regular daily application helps improve skin hydration, fine lines, and overall skin texture.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, as it has a very low likelihood of causing breakouts based on user feedback and a gentle formula. The absence of harsh ingredients helps maintain clear skin while keeping it soft and smooth.

### Can I use this cream around the eyes or on my body?

This moisturizing treatment is well-suited for mature skin on the face, but the thin skin around the eyes and body may need products specifically formulated for those areas to address unique thickness and barrier differences. Regular use of hydrating and firming ingredients helps smooth and soften these delicate zones, though care should be taken to avoid irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/es/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €59.99 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/es/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/mature-skin) — Superior fit — €13.67 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/es/p/the-ordinary/natural-moisturizing-factors-ha/for/mature-skin) — High fit — €11.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/es/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- SPF: [Bioré UV Perfect Milk SPF 50+ PA++++](https://lovi.care/skincare/es/p/biore/uv-face-milk-spf50-pa/for/mature-skin) — Superior fit — €25.88 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Dicaprylyl Carbonate, Hydrolyzed Hyaluronic Acid, Trimethylolpropane Tricaprylate Tricaprate, Tridecyl Trimellitate, Propanediol, Sh-Polypeptide-121, Polyglyceryl-3 Methylglucose Distearate, Panthenol, Niacinamide, Proline, Tocopheryl Acetate, Aloe Barbadensis Leaf Juice, Hydrolyzed Cannabis Sativa Seed Extract Cannabis Sativa Seed Extract, Hydrolyzed Rice Protein, Hydrolyzed Pea Protein, Salvia Hispanica Seed Extract, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Hibiscus Sabdariffa Fruit Extract, Ammonium Acryloyldimethyltaurate Beheneth-25 Methacrylate Crosspolymer, Hydrolyzed Linseed Seed, Castor Ipdi Copolymer Oil, Ceramide Ap, Ceramide Np, Cetearyl Alcohol, Cetearyl Glucoside, Glycerin, Hydrolyzed Sodium Hyaluronate, Coco-Caprylate Caprate, Dilinoleic Acid Propanediol Pdi Crosspolymer, Benzyl Alcohol, Zingiber Officinale Root Extract, Bisabolol, Caprylyl Glycol, Carbomer, Dimethyl Isosorbide, Dipropylene Glycol, Erythritol, Ethylhexylglycerin, Glucose, 1,2-Hexanediol, Trisodium Ethylenediamine Disuccinate, Glyceryl Monostearate, Phytosphingosine, Polyacrylate Crosspolymer-6, Polysorbate 20, Caprylhydroxamic Acid, Potassium Sorbate, Glycine, Hydroxyacetophenone, Sodium Benzoate, T-Buty Alcohol, Citric Acid, Sodium Citrate, Sodium Lactate, Triheptanoin, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin