True Botanicals Phyto-Retinol Sleep Serum for combination skin

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Questions and answers

What the research says

• Combining oral and topical astaxanthin in 30 healthy females improved skin wrinkles, age spots, elasticity, texture, and moisture, while 6 mg daily oral supplementation in 36 healthy males improved crow's feet wrinkles, elasticity, and transepidermal water loss.

  Acta Biochimica Polonica, 2012

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical application of a 5% Hippophae rhamnoides oil-in-water emulsion significantly improved skin hydration (p=0.0003) and transepidermal water loss (p=0.0087) compared to a placebo base formulation in 13 healthy male subjects over 84 days.

  Pakistan Journal of Pharmaceutical Sciences, 2014

• Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo.

  Experimental Dermatology, 2009

• Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.

  The British Journal of Dermatology, 2019

• A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris.

  Clinical, Cosmetic and Investigational Dermatology, 2015

• Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days.

  Health Science Reports, 2025

• Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction.

  Journal of Clinical and Diagnostic Research, 2017

• An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne.

  Clinical, Cosmetic and Investigational Dermatology, 2019

• Topical application of green tea extract encapsulated chitosan microparticles improved skin elasticity, melanin index, and facial wrinkles compared to a placebo in female volunteers without causing skin irritation.

  Journal of Cosmetic Dermatology, 2022

• Topical treatments containing rosehip extract may reduce the size and erythema of postsurgical scars through macrophage polarization and inflammatory cytokine inhibition, though current clinical evidence remains insufficient to recommend its routine use.

  Journal of Cosmetic Dermatology, 2024

• Sunflower and rosehip oil nanoemulsions prepared with a mix of phospholipids and synthetic emulsifiers permeated intact skin to the dermis and showed a more prominent healing effect in a human organotypic skin explant culture wound model compared to nanoemulsions prepared only with phospholipids.

  Pharmaceutics, 2023

• A nanoemulsion containing 1 mg/mL kojic dipalmitate and 5% rosehip oil demonstrated high incorporation efficiency, suitable physicochemical stability, antioxidant and depigmenting efficacy close to 1 mM ascorbic acid, and no cytotoxicity at concentrations from 0.06% to 1% in vitro.

  Pharmaceutics, 2023

• Treatment with 10 μg/mL Hippophae rhamnoides seed oil increased AQP3 mRNA and AQP3 and HAS2 protein levels in normal human epidermis keratinocytes and a reconstructed epidermis skin model compared to a negative control.

  Journal of Cosmetic Dermatology, 2021

• Topical nanoemulsion-loaded cream and gel formulations of Hippophae rhamnoides fruit oil showed superior wound contraction of 78.96% and 72.59% respectively on the 8th day compared to 62.29% for soframycin in female Sprague-Dawley rats, with no acute dermal toxicity.

  Indian Journal of Pharmacology, 2024

• Sea buckthorn oil and p-methoxycinnamic acid bioconjugates formulated in oleogels achieved 45% of the sun protection factor of an equivalent octinoxate reference oleogel.

  Molecules, 2023

• A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.

  Clinical Pharmacology, 2018

• Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief.

  Plastic and Reconstructive Surgery, 2018

• Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo.

  Journal of Alternative and Complementary Medicine, 2010

Ingredients

Camellia Sinensis Leaf Extract, Aloe Barbadensis Leaf Juice, Glycerin, Hydrogenated Oil, Hydrogenated Jojoba Oil, Hydrogenated Lecithin, Primula Veris Flower Extract Primrose Flower Extract, Mauritia Flexuosa Oil Fruit, Hippophae Rhamnoides Oil, Rosa Rubiginosa Seed Oil Rosehip Seed Oil, Salvia Hispanica Seed Oil, Astaxanthin Powder, Persea Gratissima Oil Avocado Oil, Sandalwood Oil, Avena Sativa Bran Extract Oat Bran Extract, Citrus Aurantium Dulcis Peel Extract, Cananga Odorata Oil Flower Ylang Ylang Oil Flower, Boswellia Carterii Oil Gum, Citric Acid, Sodium Phytate, Sclerotium Gum, Tocopherol, Algin, Water, Benzyl Benzoate, Benzyl Salicylate, Ethylhexylglycerin, Phenethyl Alcohol, Farnesol, Linalool, Limonene

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.