# Theramid DERMA-PEPTIDES for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/theramid/derma-peptides/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Theramid](https://lovi.care/skincare/es/brands/theramid)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Offers excellent moisturizing for your normal skin due to glycerin and peptides like Palmitoyl Tripeptide-1, which hydrate and plump the skin by supporting collagen stimulation.
- While it provides general skincare benefits, it lacks specialized ingredients like retinoids or strong antioxidants to effectively target your wrinkles and fine lines.
- The product is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/theramid/derma-peptides/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/es/p/theramid/derma-peptides/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/theramid/derma-peptides/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/es/p/theramid/derma-peptides/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/theramid/derma-peptides/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/theramid/derma-peptides/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/theramid/derma-peptides/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/es/p/theramid/derma-peptides/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/theramid/derma-peptides/for/oily-acne-prone-skin): Low

## Key ingredients

Palmitoyl Tripeptide-1, Sh-Oligopeptide-1, Palmitoyl Tetrapeptide-7

## What the research says

- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))

## What reviewers say

Users frequently praise this serum for its lightweight, non-sticky texture and its effectiveness in delivering visible anti-aging results, such as increased skin plumpness and reduced fine lines. It is also noted for its gentle, fragrance-free formulation, making it suitable for sensitive skin and compatible with other active ingredients.

- Liked: Visible anti-aging (mostly mentioned)
- Liked: Gentle formulation (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Good value (sometimes noted)
- Liked: Practical packaging (sometimes noted)
- Disliked: High expectations (rarely noted)
- Disliked: Limited availability (rarely noted)
- Disliked: Packaging preference (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes THERAMID DERMA-PEPTIDES a great fit for mature skin?

THERAMID DERMA-PEPTIDES is a great fit for mature skin because it offers excellent moisturizing with glycerin and peptides like Palmitoyl Tripeptide-1, which hydrate and plump the skin by supporting collagen stimulation. This helps keep skin soft and smooth while maintaining a safe profile without harsh ingredients.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this treatment a good fit for mature skin?

Glycerin and peptides like Palmitoyl Tripeptide-1, Sh-Oligopeptide-1, and Palmitoyl Tetrapeptide-7 make this a great fit because they hydrate and plump the skin by supporting collagen stimulation. These ingredients help improve firmness and skin structure while being very safe and unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Palmitoyl Tripeptide-1 do for mature skin?

Palmitoyl tripeptide-1 helps improve firmness, smooths out wrinkles, and enhances skin brightness when used as part of an anti-aging routine. Studies show that when applied at night or combined with complementary peptides, it supports collagen production to make mature skin look more firm and elastic.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/)

### What does EGF do for mature skin?

For mature skin, epidermal growth factor helps smooth fine lines, improve firmness, and support a more youthful look by encouraging skin renewal. It works best when paired with ingredients that deeply hydrate and protect against moisture loss to keep the skin feeling soft and smooth.
Sources: [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/24305427/), [International Journal of Molecular Medicine, 2017](https://pubmed.ncbi.nlm.nih.gov/28204807/)

### Where does this treatment go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing, for simplicity and extra safety around sun exposure. It is unlikely to irritate mature skin due to the absence of harsh ingredients.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### Can I use this treatment with retinol, and in what order?

Yes, you can use this treatment with retinol, applying the treatment after your retinol has fully absorbed into the skin. Using a barrier-supporting moisturizer alongside retinol helps keep skin comfortable and is unlikely to cause irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this treatment?

Use this treatment in your evening routine, applying it as part of your nightly steps. Daily application helps keep your skin soft and hydrated while supporting collagen.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this treatment clog pores, cause breakouts or purging for mature skin?

This treatment is safe for your skin and is unlikely to clog pores or cause breakouts because it lacks harsh ingredients that typically trigger irritation. It helps keep your skin feeling soft and smooth without heavy pore-clogging oils.

### Can I use this treatment around the eyes or on my body?

This treatment is safe to use on the body and around the eyes because it has a gentle formula with no harsh ingredients. However, skin thickness varies across the body, being thinnest on areas like the eyelids.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

## Alternatives for mature skin

- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/es/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin) — High fit — €20.00 at Notino
- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/es/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/mature-skin) — Average fit — €39.50 at Notino

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/es/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- SPF: [Bioré UV Perfect Milk SPF 50+ PA++++](https://lovi.care/skincare/es/p/biore/uv-face-milk-spf50-pa/for/mature-skin) — Superior fit — €25.88 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Propanediol, Caprylic Capric Triglyceride, Palmitoyl Tripeptide-1, Sh-Oligopeptide-1, Palmitoyl Tetrapeptide-7
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/theramid/derma-peptides/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/theramid/derma-peptides/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/theramid/derma-peptides/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/theramid/derma-peptides/for/mature-skin
- France: https://lovi.care/skincare/fr/p/theramid/derma-peptides/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/theramid/derma-peptides/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/theramid/derma-peptides/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/theramid/derma-peptides/for/mature-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/theramid/derma-peptides/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/theramid/derma-peptides/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/theramid/derma-peptides/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/theramid/derma-peptides/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/theramid/derma-peptides/for/mature-skin