the SAEM Power Ampoule for sensitive skin

How to apply

Questions and answers

What the research says

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

  Journal of Cosmetic Dermatology, 2025

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.

  International Journal of Cosmetic Science, 2018

• A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

  The Journal of Dermatological Treatment, 2017

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

Ingredients

Water, Ethanol, Glycerin, Dipropylene Glycol, 1,2-Hexanediol, Niacinamide, Methyl Gluceth-20, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Coccinia Indica Fruit Extract, Eclipta Prostrata Extract, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Piper Methysticum Stem Extract Root Leaf, Acmella Oleracea Extract, Curcuma Longa Root Extract, Ocimum Sanctum Leaf Extract, Centella Asiatica Extract, Panax Ginseng Extract Berry, Corallina Officinalis Extract, Honey Extract, Monascus Extract, Hydrogenated Lecithin, Sodium Hyaluronate, Camellia Sinensis Seed Oil, Camellia Japonica Seed Oil, Argania Spinosa Kernel Oil, Olea Europaea Oil Fruit Olive Oil Fruit, Macadamia Ternifolia Seed Oil, Helianthus Annuus Seed Oil Sunflower Seed Oil, Jojoba Seed Oil, Ammonium Acryloyldimethyltaurate Vp Copolymer, Polyglyceryl-10 Laurate, Methylpropanediol, Ceramide Np, Sodium Citrate, Sucrose Distearate, Xanthan Gum, Citric Acid, Adenosine, Fructooligosaccharides, Disodium Edta, Beta-Glucan, Polyquaternium-51, Glyceryl Stearate, Butylene Glycol, Bifida Lysate Ferment, Panthenol, Hydrolyzed Hyaluronic Acid, Raffinose, Folic Acid, Cholesterol, Aureobasidium Pullulans Ferment, Tromethamine, Palmitoyl Pentapeptide-4, Nonapeptide-1, Acetyl Hexapeptide-8, Copper Tripeptide-1, Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Hexapeptide-9, Hydrogenated Polydecene, Polyglyceryl-10 Oleate, Hydroxyacetophenone, Ethylhexylglycerin, Caprylyl Glycol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.