# The Ordinary Retinol 0.5% in Squalane for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [The Ordinary](https://lovi.care/skincare/es/brands/the-ordinary)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate rejuvenation for your combination skin, as retinol helps regulate desquamation and squalane provides emollient action to balance oily and dry areas.
- While it offers general hydration benefits, the formula is primarily supportive for your acne, blemishes, and breakouts.
- The safety profile is excellent, with no risks of irritation for your acne-prone skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/the-ordinary/retinol-0-5-in-squalane/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/the-ordinary/retinol-0-5-in-squalane/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/es/p/the-ordinary/retinol-0-5-in-squalane/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/es/p/the-ordinary/retinol-0-5-in-squalane/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/es/p/the-ordinary/retinol-0-5-in-squalane/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/the-ordinary/retinol-0-5-in-squalane/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Squalane, Caprylic Capric Triglyceride, Jojoba Seed Oil, Solanum Lycopersicum Fruit Extract Tomato Fruit Extract

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Clay jojoba oil facial masks reduced total skin lesions by a mean of 54% after 6 weeks in 133 participants with acne-prone, lesioned skin and mild acne compared to baseline. ([Forschende Komplementarmedizin, 2012](https://pubmed.ncbi.nlm.nih.gov/22585103/))
- Topical lycopene-based emulgel significantly enhanced skin hydration and elasticity while reducing erythema, melanin, and sebum contents in human volunteers compared to a placebo formulation over 12 weeks. ([European Journal of Pharmaceutics and Biopharmaceutics, 2022](https://pubmed.ncbi.nlm.nih.gov/36283632/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of an emollient emulsion containing 15.0% caprylic/capric triglyceride doubled the amount of urocanic acid isomers and increased skin hydration with reduced transepidermal water loss in healthy subjects, though it did not prevent ultraviolet-induced urocanic acid isomerization. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/37109405/))
- Topical application of jojoba wax reduced LPS-induced secretion of IL-6, IL-8, and TNFα by approximately 30% and increased the synthesis of pro-collagen III and hyaluronic acid compared to untreated skin in an ex-vivo human skin organ culture model. ([Frontiers in Pharmacology, 2024](https://pubmed.ncbi.nlm.nih.gov/38344180/))
- Topical jojoba oil application in male mice decreased exercise-induced pro-inflammatory gene expression (Il-1b and Il-6 in soleus, Il-1b in gastrocnemius) compared to untreated exercised mice. ([Biomolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41154623/))
- Nanolipidgel formulations with argan or jojoba oil and humectants demonstrate good sensory attributes, instrumental properties, and moisturizing efficacy for cosmetic application. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24772476/))
- Cosmetic formulations containing lycopene and melatonin showed significant differences in skin sebum content, hydration, elasticity, erythema index, and melanin index compared to control in 36 healthy women. ([Skin Pharmacology and Physiology, 2020](https://pubmed.ncbi.nlm.nih.gov/33070140/))
- Topical delivery of lycopene via MG- and TG-containing microemulsions significantly increased stratum corneum and viable skin layer penetration compared to a control solution, with the MG-containing microemulsion also increasing skin antioxidant activity by 10-fold. ([Journal of Pharmaceutical Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/19798758/))
- Tomato-derived nanovesicles and extract accelerated wound closure and increased cell migration in human keratinocytes and mouse fibroblasts without affecting cell proliferation. ([International Journal of Molecular Sciences, 2024](https://pubmed.ncbi.nlm.nih.gov/38473700/))

## What reviewers say

Based on a very large amount of data, users generally praise this serum as an affordable and effective entry-level retinol that improves skin texture and reduces fine lines, though the oily squalane base is a polarizing feature. While many with dry or mature skin appreciate the added hydration, those with oily or acne-prone skin frequently report that it feels heavy, greasy, and can cause congestion or purging.

- Liked: Improves skin texture (mostly mentioned)
- Liked: Unbeatable price (mostly mentioned)
- Liked: Hydrating formula (often mentioned)
- Liked: Reduces aging signs (often mentioned)
- Disliked: Greasy residue (often mentioned)
- Liked: Gentle effectiveness (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Short shelf life (sometimes noted)
- Disliked: Messy packaging (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does The Ordinary Retinol 0.5% in Squalane work for acne-prone skin?

This product works moderately well for your acne-prone skin, as retinol helps manage skin shedding while squalane balances oily and dry areas. It is unlikely to cause irritation due to the lack of harsh ingredients, but acne-prone skin typically needs products with ingredients like niacinamide, zinc PCA, or propolis to target breakouts and control oil more effectively.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Which ingredients make this serum a good fit for acne-prone skin?

Retinol and squalane make this serum a good fit for acne-prone skin by helping regulate skin renewal while providing lightweight moisture to balance oily and dry areas. To achieve a better fit for this skin type, a product of this type needs soothing ingredients like niacinamide, propolis, or zinc PCA that directly target breakouts and control oiliness without causing irritation.

### What does Retinol do for acne-prone skin?

Retinol helps acne-prone skin by speeding up cell turnover and clearing pores to reduce breakouts. It regulates skin growth and fights inflammation, though it may cause some mild peeling or stinging when you first start using it.
Sources: [Journal of Drugs in Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35816067/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/28318351/)

### What does Squalane do for acne-prone skin?

Squalane may help keep acne-prone skin soft and smooth, but peroxidated forms can trigger inflammation in skin cells. For a better fit on acne-prone skin, products need non-clogging, soothing ingredients that balance oil without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16778793/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, as evening application helps keep your skin safe around sun exposure. Acne-prone skin works best with products that offer soothing blemish care alongside gentle hydration.

### Can I use this serum with vitamin C, and in what order?

You can use this treatment with vitamin C by applying vitamin C in the morning and this serum at night to avoid overwhelming your skin. This product helps support blemishes and breakouts, but acne-prone skin also needs ingredients that target underlying causes and control oil.
Sources: [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/)

### How often should I use this serum?

Apply this treatment in your evening routine for simplicity and extra safety around sun exposure. Acne-prone skin needs a product with retinols and jojoba oil to help target blemishes and keep skin balanced.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This treatment may occasionally cause breakouts, as reviewers note a moderate risk of clogged pores and some users experience blemishes. However, it is unlikely to cause irritation because it lacks harsh ingredients, though acne-prone skin often benefits more from lightweight, oil-free formulas that balance oil without heavy textures.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/es/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — €29.76 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin) — High fit — €21.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/es/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €11.99 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — €34.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/es/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €17.49 at Amazon

## Where to buy

- Lookfantastic: €9.66 (https://www.lookfantastic.es/p/the-ordinary-retinol-serum-0.5-in-squalane-30ml/11638502/)
Prices checked 2 Nov 2026.

## Ingredients

Squalane, Caprylic Capric Triglyceride, Jojoba Seed Oil, Retinol, Solanum Lycopersicum Fruit Extract Tomato Fruit Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Hydroxymethoxyphenyl Decanone, Bht
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin