# The Ordinary Multi-Peptide + Copper Peptides 1% Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [The Ordinary](https://lovi.care/skincare/es/brands/the-ordinary)
Category: [Serums and treatments](https://lovi.care/skincare/es/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin firming and plumping for your combination skin due to the presence of multiple peptides like Copper Tripeptide-1 and Acetyl Hexapeptide-8, which work synergistically to enhance skin elasticity and reduce the appearance of fine lines.
- Glycerin and Sodium Hyaluronate Crosspolymer provide excellent humectant action, addressing general skincare benefits like hydration and supporting oily shine concerns without compromising your combination skin.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing agents like Allantoin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Sodium Hyaluronate, Lactococcus Lysate Ferment

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

A notable number of reviews mention a metallic scent and some users report experiencing irritation or stickiness, particularly those with sensitive skin.

- Liked: Improves firmness (often mentioned)
- Liked: Lightweight absorption (often mentioned)
- Liked: Smooths texture (often mentioned)
- Disliked: Unpleasant scent (often mentioned)
- Liked: Accelerates healing (sometimes noted)
- Liked: Value for money (sometimes noted)
- Disliked: Initial stickiness (sometimes noted)
- Disliked: Product conflicts (sometimes noted)
- Disliked: Pricey for brand (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes The Ordinary Multi-Peptide + Copper Peptides 1% Serum a great fit for combination skin?

This serum is a great fit for your combination skin because multiple peptides like Copper Tripeptide-1 and Acetyl Hexapeptide-8 help firm and smooth out fine lines. Glycerin and Sodium Hyaluronate provide deep hydration while supporting oily shine concerns without clogging pores. It also has a very safe profile with soothing Allantoin, meaning it is unlikely to cause irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this serum a good fit for combination skin?

This serum is a great fit for your combination skin because it uses multiple peptides like Copper Tripeptide-1 and Acetyl Hexapeptide-8 to firm the skin and smooth out fine lines. Glycerin and Sodium Hyaluronate also provide essential hydration while supporting oily shine concerns. It has a very safe profile with soothing Allantoin to keep skin calm and comfortable.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Copper Tripeptide-1 do for combination skin?

Copper Tripeptide-1 helps calm combination skin, smooth fine lines, and support a strong skin barrier. It protects against sun damage and helps tighten the skin, keeping it looking firm and healthy.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/), [BioMed Research International, 2015](https://pubmed.ncbi.nlm.nih.gov/26236730/)

### What does Argireline do for combination skin?

Argireline helps smooth out lines and keeps combination skin feeling soft when applied twice daily. This ingredient may reduce wrinkle depth and improve overall skin texture, though its absorption through the skin is quite low.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and before your moisturizer. Putting it in the evening helps keep things simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the peptide serum first and following with your retinol once it absorbs. This combination helps smooth fine lines while keeping your skin calm, as the gentle formula is unlikely to cause irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

### How often should I use this serum?

This serum is used in your evening routine, applying it once a day for simplicity and extra safety around sun exposure. Some serums of this type can also be used in the morning or twice a day if your skin tolerates them well.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for combination skin because it has a very safe formula free of heavy, pore-clogging ingredients. It also helps manage oily shine while keeping the skin hydrated.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Augustinus Bader The Serum](https://lovi.care/skincare/es/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €333.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/es/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — €169.99 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — €21.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/es/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — €97.52 at Amazon

## Where to buy

- Amazon.de: €27.95 (https://www.amazon.de/dp/B0C9DXGXZ3?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €33.24 (https://www.lookfantastic.es/p/the-ordinary-multi-peptide-copper-peptides-1-serum-30ml/14853143/)
- Notino: €35.30 (https://www.notino.es/the-ordinary/multi-peptide-copper-peptides-1-serum-antiarrugas-e-iluminador/p-16193594/)
Prices checked 16 Oct – 6 Nov 2026.

## Ingredients

Water, Glycerin, Lactococcus Lysate Ferment, Copper Tripeptide-1, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium Pca, Pca, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, Dimethyl Isosorbide, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/combination-skin